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Source
NICE
Published
25 Mar 2026
Last Indexed
25 Mar 2026
Specialty
Gastroenterology

NICE NG129 covers the management of Crohn's disease including induction of remission with corticosteroids and enteral nutrition, maintenance therapy, and biologic agents.

Key Recommendations

  • Corticosteroids (prednisolone/budesonide) or exclusive enteral nutrition for induction of remission
  • Azathioprine or mercaptopurine for maintenance of remission
  • Anti-TNF therapy (adalimumab or infliximab) for active luminal Crohn's failing conventional therapy
  • Combination therapy (anti-TNF + immunomodulator) superior to monotherapy
  • Vedolizumab or ustekinumab as alternatives
  • Methotrexate for patients intolerant of thiopurines
  • Surgery for localised ileocaecal disease, obstruction, or fistulating disease
ClinicalIQ Editorial Note: This guideline summary is indexed from NICE. Always refer to the full guideline for complete recommendations. Last indexed: 25 Mar 2026
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