Respiratory / COPD / Asthma
Respiratory guidelines, trial intelligence, inhaled and biologic therapy mechanisms, and education across asthma, COPD and severe respiratory disease.
Latest Guidelines
Brensocatib for treating non-cystic fibrosis bronchiectasis in people 12 years and over (terminated evaluation)
Evaluation terminated: Brensocatib for non-CF bronchiectasis is no longer under NICE appraisal—do not initiate new treatment pathways for this indication pending alternative guidance from your local…
Mepolizumab for maintenance treatment of uncontrolled chronic obstructive pulmonary disease with raised blood eosinophils
Mepolizumab is recommended for patients with uncontrolled COPD and blood eosinophils ≥100 cells/μL; check eosinophil levels before initiating treatment as this is a mandatory eligibility criterion.…
UK Achondroplasia Network’s consensus guideline for multidisciplinary care of children and young people with achondroplasia: NICE review
Establish multidisciplinary team review at diagnosis and at key developmental stages (infancy, pre-school, school age, adolescence) to monitor for complications including spinal stenosis, foramen magnum stenosis,…
Digital technologies to support self-management of asthma: early-use assessment
Use digital asthma self-management tools (apps, web platforms, wearables) as adjuncts to standard care to help patients monitor symptoms, track triggers, and improve medication adherence—particularly beneficial…
Digital technologies for applying algorithms to spirometry to support asthma and COPD diagnosis in primary care and community diagnostic centres: early-use assessment
Digital spirometry algorithms can improve diagnostic accuracy for asthma and COPD in primary care and community diagnostic centres, potentially reducing unnecessary referrals to secondary care and…
GOLD 2025 Report: Global Strategy for Prevention, Diagnosis and Management of COPD
GOLD 2025 updates COPD diagnosis criteria: spirometry FEV1/FVC
Trial Radar
Is the Vaginal Microbiome and Metabolome Associated With Spontaneous Preterm Birth (sPTB) in Multiple Pregnancies?
Study investigates whether vaginal bacteria in twin pregnancies are linked to early delivery to identify potential prevention treatments.
PHASE4A Randomized Controlled Trial Comparing Percutaneous CT-Guided Biopsy and Shape-Sensing Robotic-Assisted Bronchoscopy
What is being tested: The ENCOMPASS study compares diagnostic accuracy and safety outcomes between CT-guided percutaneous lung biopsy…
PHASE1To Identify if a COPD Self-management App Can Safety and Appropriately Identify When Patients Are Not on the Best Medication Plan for Their COPD Symptoms and Support Their COPD Management.
What is being tested: A COPD self-management app designed to safely and accurately identify when patients are not…
PHASE1A Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Two GSK3862995B Formulations in Healthy Participants
What is being tested: Two different formulations of GSK3862995B, an investigational medicine, are being compared to evaluate their…
Clinical News
AI sleep data could provide one-week early warning of flu and COVID-19
Sleep-tracking apps analysing cough patterns can detect flu and COVID-19 approximately one week before symptom onset, potentially enabling…
02 Sep 2026Children as young as six going to A&E in mental health crisis
Children as young as six are presenting to A&E with acute mental health crises, including self-harm and eating…
01 Sep 2026‘Baby Tommy’s here, Chelsea’s not’: First-time mum dies in childbirth
Maternal cardiac arrest during labour can occur unexpectedly even in apparently low-risk pregnancies, highlighting the importance of maintaining…
27 Aug 2026Parents urged to vaccinate children at the right time to protect them
Childhood vaccination uptake appears to be stabilising at primary school entry, suggesting improvement in immunisation programme performance Timely…
Relevant Mechanisms
Beta-2 Adrenergic and Muscarinic Receptors — COPD/Asthma
Beta-2 Adrenergic and Muscarinic Receptors — COPD/Asthma is a clinically relevant Drug Science explainer. Bronchodilation in obstructive airway disease is…
MechanismCFTR Modulation
CFTR Modulation is a clinically relevant Drug Science explainer. Cystic fibrosis (CF) is caused by mutations in the CFTR gene…
MechanismEGFR Pathway
EGFR Pathway is a clinically relevant Drug Science explainer. The epidermal growth factor receptor (EGFR/ErbB1/HER1) is a transmembrane receptor tyrosine…
MechanismIL-4/IL-13 Axis
IL-4/IL-13 Axis is a clinically relevant Drug Science explainer. Interleukin-4 (IL-4) and interleukin-13 (IL-13) are hallmark type 2 cytokines produced…
MechanismIL-5 Pathway — Severe Eosinophilic Asthma
IL-5 Pathway — Severe Eosinophilic Asthma is a clinically relevant Drug Science explainer. Interleukin-5 (IL-5) is the principal cytokine governing…
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