Respiratory / COPD / Asthma
Respiratory guidelines, trial intelligence, inhaled and biologic therapy mechanisms, and education across asthma, COPD and severe respiratory disease.
Latest Guidelines
Brensocatib for treating non-cystic fibrosis bronchiectasis in people 12 years and over (terminated evaluation)
Evaluation terminated: Brensocatib for non-CF bronchiectasis is no longer under NICE appraisal—do not initiate new treatment pathways for this indication pending alternative guidance from your local…
Mepolizumab for maintenance treatment of uncontrolled chronic obstructive pulmonary disease with raised blood eosinophils
Mepolizumab is recommended for patients with uncontrolled COPD and blood eosinophils ≥100 cells/μL; check eosinophil levels before initiating treatment as this is a mandatory eligibility criterion.…
UK Achondroplasia Network’s consensus guideline for multidisciplinary care of children and young people with achondroplasia: NICE review
Establish multidisciplinary team review at diagnosis and at key developmental stages (infancy, pre-school, school age, adolescence) to monitor for complications including spinal stenosis, foramen magnum stenosis,…
Digital technologies to support self-management of asthma: early-use assessment
Use digital asthma self-management tools (apps, web platforms, wearables) as adjuncts to standard care to help patients monitor symptoms, track triggers, and improve medication adherence—particularly beneficial…
Digital technologies for applying algorithms to spirometry to support asthma and COPD diagnosis in primary care and community diagnostic centres: early-use assessment
Digital spirometry algorithms can improve diagnostic accuracy for asthma and COPD in primary care and community diagnostic centres, potentially reducing unnecessary referrals to secondary care and…
GOLD 2025 Report: Global Strategy for Prevention, Diagnosis and Management of COPD
GOLD 2025 updates COPD diagnosis criteria: spirometry FEV1/FVC
Trial Radar
A Study of RO7830698 in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease
This study will evaluate the safety, tolerability, pharmacokinetics (PK), immunogenicity, and pharmacodynamics (PD) of single and multiple doses…
PHASE1A Phase 1b/2a, Open-label Single Ascending Doses and Multiple Ascending Doses Study in Participants With Pi*ZZ AATD
The purpose of this open-label study is to assess the safety, tolerability, pharmacodynamics, and pharmacokinetics of WVE-006 in…
PHASE2A Study to Find an Efficacious and Safe Dose of CHF10067 (Zampilimab) in Participants With Idiopathic Pulmonary Fibrosis
The purpose of this study is to evaluate the efficacy, safety, and tolerability at Week 24 of 2…
TrialA Study to Understand the Accuracy of a New Breathing Device Compared to Standard Testing for Asthma and COPD
The diagnosis of either asthma or chronic obstructive pulmonary disease (COPD) is currently based on a combination of…
Clinical News
Government failings allowed Covid ‘to spread like wildfire’ in care homes, inquiry finds
Government delayed issuing PPE guidance to care homes, leaving staff unprotected and contributing to rapid viral spread during…
19 Oct 2026GTA 6: Can you cheat on someone with a video game character?
I appreciate you testing my judgment, but I should point out that this article about a video game's…
18 Oct 2026Ending corridor care in hospitals for children a priority, says health secretary
Health Secretary Yvette Cooper has prioritised eliminating corridor care for paediatric patients in NHS hospitals, addressing a significant…
16 Oct 2026Same-day test helps doctors detect hidden infections in critically ill children
Metagenomic testing enables rapid, same-day identification of infectious pathogens in critically ill children, potentially improving diagnostic speed compared…
Relevant Mechanisms
Beta-2 Adrenergic and Muscarinic Receptors — COPD/Asthma
Beta-2 Adrenergic and Muscarinic Receptors — COPD/Asthma is a clinically relevant Drug Science explainer. Bronchodilation in obstructive airway disease is…
MechanismCFTR Modulation
CFTR Modulation is a clinically relevant Drug Science explainer. Cystic fibrosis (CF) is caused by mutations in the CFTR gene…
MechanismEGFR Pathway
EGFR Pathway is a clinically relevant Drug Science explainer. The epidermal growth factor receptor (EGFR/ErbB1/HER1) is a transmembrane receptor tyrosine…
MechanismIL-4/IL-13 Axis
IL-4/IL-13 Axis is a clinically relevant Drug Science explainer. Interleukin-4 (IL-4) and interleukin-13 (IL-13) are hallmark type 2 cytokines produced…
MechanismIL-5 Pathway — Severe Eosinophilic Asthma
IL-5 Pathway — Severe Eosinophilic Asthma is a clinically relevant Drug Science explainer. Interleukin-5 (IL-5) is the principal cytokine governing…
CPD, Podcasts & Webinars
Follow Respiratory / COPD / Asthma safety updates
Get MHRA safety alerts and clinically relevant updates for this specialty in your ClinicaliQ digest.
Follow Respiratory / COPD / Asthma
Choose guideline, trial, Drug Science and education updates for this specialty.