Neurology
Neurology guidelines, trial updates, mechanisms and education across headache, neuroinflammation, movement disorders and specialist prescribing.
Latest Guidelines
Atogepant for treating migraine
Atogepant is recommended as a preventive treatment option for episodic migraine in adults; consider initiating in patients with ≥4 migraine days per month who have failed…
Oxybutynin hydrochloride for managing neurogenic detrusor overactivity in people 6 years and over with spinal cord injury or spina bifida (terminated appraisal)
Oxybutynin is effective for neurogenic detrusor overactivity in patients aged 6+ years with spinal cord injury or spina bifida—consider as first-line antimuscarinic therapy for managing symptoms…
2022 EAN/EFNS Guidelines on Dementia Diagnosis and Management
This EAN guideline addresses 2022 EAN/EFNS Guidelines on Dementia Diagnosis and Management in Neurology. Use it to review current recommendation wording, eligibility criteria, and implementation considerations…
2023 EAN Guidelines on the Management of Multiple Sclerosis
This EAN guideline addresses 2023 EAN Guidelines on the Management of Multiple Sclerosis in Neurology. Use it to review current recommendation wording, eligibility criteria, and implementation…
2022 EAN Guidelines on Epilepsy Management in Adults
This EAN guideline addresses 2022 EAN Guidelines on Epilepsy Management in Adults in Neurology. Use it to review current recommendation wording, eligibility criteria, and implementation considerations…
Transient Loss of Consciousness (NICE CG109)
Obtain detailed witness account documenting prodrome, colour during episode, duration of unconsciousness, injury pattern, and postictal confusion to distinguish between syncope and seizure Perform 12-lead ECG…
Trial Radar
Real-World Study of Foslevodopa/Foscarbidopa to Assess Quality of Life Outcomes in Adult Participants Earlier Within Advanced Parkinson Disease
What is being tested: Foslevodopa/foscarbidopa (a continuous subcutaneous infusion therapy) is being evaluated for its effects on quality…
PHASE1A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson’s Disease
Drug being tested: LY3962681, a novel investigational compound undergoing evaluation for safety, tolerability, and pharmacokinetic/pharmacodynamic properties in both…
PHASE3A Study of Donanemab (LY3002813) in Participants With Early Alzheimer’s Disease (TRAILBLAZER-ALZ 2)
Donanemab slows cognitive decline in early Alzheimer's disease; follow-up study monitors long-term safety and effectiveness.
PHASE1A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of DNL921 in Healthy Participants and Participants With Alzheimer’s Disease
Drug being tested: DNL921 is a novel investigational agent undergoing Phase 1/1b evaluation for safety, tolerability, pharmacokinetics, and…
Clinical News
Ryan Jones: Unbreakable
Early-onset dementia is occurring in former rugby players, highlighting potential long-term neurological consequences of repeated head trauma sustained…
02 Sep 2026Former nurse dies amid dementia drug shortages
Dementia medication shortages are affecting patient care and outcomes, with documented cases of treatment interruptions leading to clinical…
02 Sep 2026Families hit by long waits for dementia diagnosis
Dementia diagnosis delays are widespread, with patients experiencing waits of months to years, creating prolonged uncertainty for families…
03 Aug 2026Student quits university due to epilepsy medicine shortages
Epilepsy medication shortages are affecting patient access – Supply issues are severe enough to impact students' ability to…
Relevant Mechanisms
CGRP Pathway — Migraine
CGRP Pathway — Migraine is a clinically relevant Drug Science explainer. Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide…
MechanismDopamine D2 Receptor
Dopamine D2 Receptor is a clinically relevant Drug Science explainer. Dopamine (DA) is a monoamine neurotransmitter with distinct functional roles…
MechanismS1P Receptor Modulation — MS/IBD
S1P Receptor Modulation — MS/IBD is a clinically relevant Drug Science explainer. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite generated…
MechanismSerotonin/Noradrenaline Reuptake
Serotonin/Noradrenaline Reuptake is a clinically relevant Drug Science explainer. Serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (norepinephrine, NA) are monoamine neurotransmitters with…
CPD, Podcasts & Webinars
Follow Neurology safety updates
Get MHRA safety alerts and clinically relevant updates for this specialty in your ClinicaliQ digest.
Follow Neurology
Choose guideline, trial, Drug Science and education updates for this specialty.