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Trial Radar

1003 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

1003 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

active not recruiting Phase III
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Thyroid Eye Disease
Satralizumab injection tested for treating thyroid eye disease by blocking inflammation.
14 May 2026 NCT06106828
● Recruiting Phase III
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
Trial testing whether brenipatide reduces alcohol use better than placebo in people with moderate-to-severe alcohol use disorder over 56 weeks.
14 May 2026 NCT07219966
active not recruiting Phase I / Phase II
INCB000928 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Anemia Due to Myeloproliferative Disorders
Trial testing INCB000928 alone or with ruxolitinib to treat anemia in myelofibrosis patients, assessing safety and effectiveness.
14 May 2026 NCT04455841
active not recruiting Phase III Oncology
DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)
Tovorafenib compared to standard chemotherapy for treating children with low-grade brain tumours with RAF mutations.
14 May 2026 NCT05566795
● Recruiting Phase III Oncology
A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
This study will assess the effect of Dato-DXd in combination with osimertinib or Dato-DXd monotherapy versus platinum-based doublet chemotherapy in terms of progression-free survival…
14 May 2026 NCT06417814
● Recruiting Phase III Oncology
A Study to Evaluate the Benefit of Adding Durvalumab After Chemotherapy, Durvalumab and Surgery in Patients With Early-stage, Operable, Non-small Cell Lung Cancer.
ADOPT-lung is an international, multicentre, open-label randomised phase III trial. Protocol treatment consists of 3-4 cycles of neoadjuvant durvalumab in combination with platinum-based doublet…
14 May 2026 NCT06284317
● Recruiting Phase I Respiratory / COPD / Asthma
A Two-part Study to Investigate the Effects in Adults of Two Doses of Golexanolone in Patients With Primary Biliary Cholangitis (PBC) With Fatigue and Cognitive Dysfunction
The present phase 1b/2 randomised, double-blind, placebo-controlled, two-part study is designed to evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of two dose…
14 May 2026 NCT07304843
● Recruiting Respiratory / COPD / Asthma
Chronic Nausea and Vomiting in Patients With Normal Gastric Emptying Using the Enterra® Therapy System (NAVIGATE)
The purpose of this research study is to determine if the Enterra® Therapy System can decrease nausea and vomiting symptoms and improve the quality…
14 May 2026 NCT06464926
● Recruiting Respiratory / COPD / Asthma
Health Impact of Non-Tuberculous Mycobacteria Pulmonary Disease (NTM-PD)
Nontuberculous mycobacteria (NTM) are environmental organisms found in soil and water. The majority do not cause human disease. When they do, this is mostly…
14 May 2026 NCT07192705
● Recruiting Phase III Oncology
Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma
Multiple myeloma (MM) is a cancer of the blood's plasma cells. The cancer is typically found in the bones and bone marrow (the spongy…
14 May 2026 NCT06158841
● Recruiting Phase II Oncology
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
Ficerafusp alfa is directed against two targets, Epidermal Growth Factor Receptor (EGFR) and Transforming Growth Factor beta (TGF-β). This study intends to evaluate the…
14 May 2026 NCT06788990
● Recruiting Phase I Oncology
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
The purpose of this study is to assess the safety and efficacy of surovatamig (formerly AZD0486) administered as monotherapy or in combination with other…
14 May 2026 NCT06564038
● Recruiting Phase II Oncology
Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
This is a Phase II, open-label, multi-drug, multi-centre study designed to assess the efficacy, safety, tolerability, pharmacokinetics, and immunogenicity of novel combination therapies in…
14 May 2026 NCT05702229
● Recruiting Phase III Oncology
A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.
The study is a randomized, double-blind, placebo-controlled, multicenter, Phase III study, to evaluate efficacy, safety and tolerability of iptacopan in patients with AChR+ gMG…
14 May 2026 NCT06517758
active not recruiting Phase II Neurology
Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
New drug BIA 28-6156 tested against placebo to slow motor decline in GBA gene-linked Parkinson's disease over 78 weeks.
13 May 2026 NCT05819359
active not recruiting Phase II Neurology
A Study of JNJ-64042056 in Participants With Preclinical Alzheimer’s Disease
An experimental drug tested to see if it slows tau protein buildup in early Alzheimer's disease using brain scanning.
13 May 2026 NCT06544616
active not recruiting Phase I Oncology
Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene)
Trial testing increasing doses of zongertinib tablet in advanced cancer with HER2 gene changes, then evaluating tumour response at tolerated dose.
13 May 2026 NCT04886804
active not recruiting Phase III
A Study of 2 Doses of Ritlecitinib in People 12 Years of Age and Older With Alopecia Areata
Trial comparing two doses of ritlecitinib (50mg vs 100mg daily) for treating severe alopecia areata in people aged 12+.
13 May 2026 NCT06873945
active not recruiting Oncology
Plasma Analysis for Response Assessment and to DIrect the manaGement of Metastatic Prostate Cancer
PARADIGM Study Summary Blood tests measuring cancer DNA may help predict which prostate cancer treatments work best for individual patients.
13 May 2026 NCT04067713
active not recruiting Phase II Diabetes / Metabolic
A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity
A new drug combined with tirzepatide tested against tirzepatide alone for weight loss in overweight or obese adults over 48 weeks.
13 May 2026 NCT06965413
active not recruiting Phase III Oncology
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
T-DXd compared to T-DM1 for HER2-positive breast cancer with residual disease after chemotherapy.
13 May 2026 NCT04622319
active not recruiting Phase III Oncology
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
Venetoclax extension study collecting long-term safety data in patients continuing to benefit from treatment.
13 May 2026 NCT03844048
● Recruiting Phase II Dermatology
A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)
A 35-week trial testing whether brenipatide injections improve symptoms and are safe in patients with IBS-diarrhea compared to placebo.
13 May 2026 NCT07545759
● Recruiting Phase II Neurology
Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous Systemic Sclerosis
What is being tested: Rapcabtagene autoleucel, a CAR-T cell therapy administered as a single infusion after lymphodepletion, compared against rituximab in patients with severe,…
13 May 2026 NCT06655896
● Recruiting Phase III Gastroenterology
Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein
Treatment being tested: Fazirsiran, an investigational therapy designed to reduce liver fibrosis in patients with alpha-1 antitrypsin (AAT) deficiency-related liver disease, compared against placebo.…
13 May 2026 NCT05677971
● Recruiting Cardiology / Cardiovascular
Exercise Intervention as an Adjunct to Medical Therapy in Newly Diagnosed Patients With Pulmonary Arterial Hypertension
Intervention being tested: A structured exercise programme initiated early after pulmonary arterial hypertension (PAH) diagnosis, delivered alongside standard medical therapy, to evaluate improvements in…
13 May 2026 NCT07366879
● Recruiting Phase III Cardiology / Cardiovascular
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
What is being tested: The efficacy of triple therapy (budesonide/glycopyrronium/formoterol – BGF MDI) versus dual therapy (glycopyrronium/formoterol – GFF MDI) in reducing cardiopulmonary outcomes…
13 May 2026 NCT06283966
● Recruiting Cardiology / Cardiovascular
Optical Coherence Tomography And NEphropathy: The OCTANE Study
What is being tested: Optical coherence tomography (OCT) imaging to detect structural and functional changes in blood vessels in patients with hypertension and chronic…
13 May 2026 NCT02132741
● Recruiting Cardiology / Cardiovascular
Chronic Limb-Threatening Ischemia Treated With Intravascular Lithotripsy Observational Study
Intervention being tested: Real-world effectiveness and safety of intravascular lithotripsy (IVL) using the Shockwave system to treat calcified arterial lesions in the femoropopliteal and…
13 May 2026 NCT06149650
● Recruiting Phase II Cardiology / Cardiovascular
Transition to KPL-387 Monotherapy Dosing & Administration Study
What is being tested: KPL-387 monotherapy dosing regimens designed to safely transition patients from established pericarditis treatments, evaluating efficacy and safety profiles during this…
13 May 2026 NCT07288216
● Recruiting Phase I Oncology
A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)
What is being tested: Raludotatug deruxtecan (MK-5909-003), a novel targeted therapy being investigated for treating relapsed high-grade serous ovarian cancer—a particularly aggressive form that…
13 May 2026 NCT06843447
● Recruiting Phase II Oncology
Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)
What is being tested: Trastuzumab deruxtecan (T-DXd), a HER2-targeted antibody-drug conjugate, administered alone or combined with chemotherapy and/or immunotherapy in patients with HER2-expressing advanced…
13 May 2026 NCT04379596
● Recruiting Phase III Oncology
Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations
What is being tested: Datopotamab deruxtecan (Dato-DXd), a novel antibody-drug conjugate, combined with the PD-L1 inhibitor pembrolizumab versus pembrolizumab monotherapy as first-line treatment for…
13 May 2026 NCT05215340
● Recruiting Phase III
Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency
New oral medication tested in children with growth hormone deficiency to see if it works and identify who benefits most.
12 May 2026 NCT06948214
● Recruiting Phase I
A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)
Early-stage trial testing new oral JAK2 inhibitor in myelofibrosis patients who failed previous JAK inhibitor treatment.
12 May 2026 NCT06343805
active not recruiting Phase III Oncology
A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer
T-DXd improves outcomes in HER2-positive advanced breast cancer patients previously treated with anti-HER2 drugs, including those with brain metastases.
12 May 2026 NCT04739761
active not recruiting
Post-market Clinical Follow-up (PMCF) Study of the Poly-Tape Devices for Medial Patellofemoral Ligament (MPFL) Reconstruction
Long-term safety study of Poly-Tape devices for kneecap ligament reconstruction surgery in 55 patients over five years.
12 May 2026 NCT05264389
● Recruiting Phase IV
Nuwiq for Perioperative Management Of Patients With Haemophilia A on Emicizumab Regular Prophylaxis Study
Recombinant factor VIII safely prevents bleeding during surgery in haemophilia A patients already on emicizumab prophylaxis.
12 May 2026 NCT05935358
active not recruiting Phase I Oncology
Ascending Doses of Ceralasertib in Combination With Chemotherapy and/or Novel Anti Cancer Agents
Early-stage trial testing increasing doses of ceralasertib combined with chemotherapy and immunotherapy drugs in advanced cancer patients.
12 May 2026 NCT02264678
active not recruiting Gastroenterology
Application of Functional Renal MRI to Improve Assessment of Chronic Kidney Disease
MRI scan measures kidney structure and function to predict chronic kidney disease progression and guide treatment decisions.
12 May 2026 NCT04238299
● Recruiting Phase III
A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
A drug called lebrikizumab was tested for 18 months to see if it helps patients with nasal polyps who already use nasal steroid sprays.
12 May 2026 NCT06338995
● Recruiting Phase III Oncology
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
Treatment being tested: Rilvegostomig (a FGFR4 inhibitor) combined with bevacizumab, evaluated with or without tremelimumab (CTLA-4 inhibitor), compared to the current standard atezolizumab plus…
12 May 2026 NCT06921785
● Recruiting Phase I
Safety, Tolerability and Pharmacokinetics of AZD1613 in Adults With Autosomal Dominant Polycystic Kidney Disease
Drug being tested: AZD1613 is undergoing evaluation for safety, tolerability, and pharmacokinetics via subcutaneous or intravenous administration in adults with autosomal dominant polycystic kidney…
12 May 2026 NCT07228364
● Recruiting Phase II Diabetes / Metabolic
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
What is being tested: SAB-142, a human anti-thymocyte immunoglobulin, is being evaluated to determine whether it can arrest the progression of Type 1 Diabetes…
12 May 2026 NCT07187531
● Recruiting Cardiology / Cardiovascular
Utilising AI Analysis of Sounds To prEdict heaRt failurE decOmpensation
What is being tested: AI-powered analysis of respiratory and cardiac sounds to predict acute decompensated heart failure (ADHF) before clinical deterioration occurs, potentially enabling…
12 May 2026 NCT06555757
● Recruiting Phase II Cardiology / Cardiovascular
Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases
What is being tested: Sparsentan (a dual endothelin receptor antagonist and angiotensin II receptor blocker) administered as oral suspension or tablets in once-daily dosing…
12 May 2026 NCT05003986
● Recruiting Cardiology / Cardiovascular
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)
What is being tested: STEPCARE-MAKE evaluates how three interventions—sedation strategies, temperature management, and blood pressure targets—affect acute kidney injury (MAKE) outcomes in comatose survivors…
12 May 2026 NCT07579390
● Recruiting Phase II Oncology
A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Treatment being tested: Raludotatug deruxtecan (R-DXd), a novel targeted therapy designed to treat platinum-resistant high-grade ovarian, primary peritoneal, and fallopian tube cancers by combining…
12 May 2026 NCT06161025
● Recruiting Phase I Oncology
Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)
Treatment Being Tested: Combination therapies (including pembrolizumab with investigational agents) for refractory renal cell carcinoma in patients with recurrent disease during or after anti-PD-(L)1…
12 May 2026 NCT07049926
● Recruiting Oncology
Selecting Hypoxic Tumours for Treatment Modification
What is being tested: Methods to identify and select patients with hypoxic solid tumours for treatment intensification strategies, since hypoxic tumours demonstrate reduced radiotherapy…
12 May 2026 NCT06787053