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Trial Radar

1003 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

1003 recruiting AI clinical summaries
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Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

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active not recruiting Oncology
A Study for the Participants With Metastatic Hormone Sensitive Prostate Cancer (mHSPC) Treated With Androgen Deprivation Therapy (ADT) Plus Apalutamide or Enzalutamide
Real-world comparison of apalutamide versus enzalutamide, both combined with standard hormone therapy, in men with advanced prostate cancer.
08 May 2026 NCT05901649
active not recruiting Phase II Infectious Disease
Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney Injury (CLEAR-AKI)
TIN816 drug tested at three doses in critically ill patients with kidney injury from sepsis to assess safety and effectiveness.
08 May 2026 NCT05996835
active not recruiting Phase II / Phase III Gastroenterology
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn’s Disease
Guselkumab, a new antibody treatment, shows promise for reducing symptoms and inflammation in moderate-to-severe Crohn's disease.
08 May 2026 NCT03466411
active not recruiting Phase III Cardiology / Cardiovascular
A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation
Milvexian tested against apixaban for preventing stroke and blood clots in atrial fibrillation patients.
08 May 2026 NCT05757869
active not recruiting Gastroenterology
RETHINK REFLUX Registry
Long-term safety study tracking patients with surgically implanted LINX reflux devices for up to 10 years after implantation.
08 May 2026 NCT04253392
● Recruiting Phase III
A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment
Pegtibatinase versus placebo for homocystinuria in patients aged 12-65 on standard treatment, measuring safety and effectiveness over 24 weeks.
08 May 2026 NCT06247085
● Recruiting Phase II
A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
Long-term safety follow-up study of a gene therapy injection into the eye for geographic atrophy, a type of age-related macular degeneration.
08 May 2026 NCT06635148
active not recruiting Phase III Rheumatology
A Study to Evaluate the Long-term Safety, Tolerability and Efficacy of Bimekizumab in Subjects With Active Axial Spondyloarthritis Including Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis
Bimekizumab long-term safety and effectiveness study in ankylosing spondylitis and related spine conditions.
08 May 2026 NCT04436640
active not recruiting Phase III Rare Diseases
Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene
Gene therapy injection into the eye shows promise for treating inherited blindness caused by RPGR gene faults in men.
08 May 2026 NCT04794101
active not recruiting Phase II / Phase III Gastroenterology
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
Guselkumab was tested for treating moderate to severe ulcerative colitis, assessing whether it works and is safe.
08 May 2026 NCT04033445
● Recruiting Phase II Cardiology / Cardiovascular
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Drug being tested: BMS-986435/MYK-224, a novel therapeutic agent being evaluated for safety, tolerability, and pharmacokinetic exposure in patients with symptomatic HFpEF. Patient eligibility: The…
08 May 2026 NCT06122779
● Recruiting Cardiology / Cardiovascular
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
What is being tested: Long-term reliability and performance of marketed Medtronic cardiac rhythm management devices (such as pacemakers and implantable cardioverter-defibrillators) through analysis of…
08 May 2026 NCT00271180
● Recruiting Oncology
International Registry for Men With Advanced Prostate Cancer (IRONMAN)
What is being tested: IRONMAN is establishing an international prospective registry of ≥5,000 men with advanced prostate cancer, including metastatic hormone-sensitive prostate cancer (mHSPC)…
08 May 2026 NCT03151629
● Recruiting Phase I Oncology
ACTinium in Castrate-RESistant Prostate Cancer After LUTEtium
What is being tested: Actinium-225 (a targeted alpha particle therapy) in patients with advanced metastatic castration-resistant prostate cancer who have previously received Lutetium-177 treatment,…
08 May 2026 NCT07414940
● Recruiting Phase III Oncology
A Long-term Extension Study of PCI-32765 (Ibrutinib)
What is being tested: Long-term safety and efficacy of ibrutinib (PCI-32765), a Bruton's tyrosine kinase (BTK) inhibitor, in patients who have completed primary ibrutinib…
08 May 2026 NCT01804686
● Recruiting Oncology
A Study Measuring Markers of Airway Inflammation in Breath Samples From People With Respiratory Diseases and Healthy Volunteers.
What is being tested: Non-invasive measurement of airway inflammation markers in breath samples to develop a potential screening tool for lung cancer, comparing patients…
08 May 2026 NCT07426718
● Recruiting Oncology
Chemotherapy Induced Cognitive Impairment
What is being tested: Investigation of chemotherapy-induced cognitive impairment ("chemo fog" or "chemobrain"), a poorly understood neurotoxic side-effect of chemotherapy that affects patient cognition…
08 May 2026 NCT05740787
● Recruiting Phase I Oncology
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
Treatment Being Tested: BMS-986507 in combination regimens for advanced solid tumors, with assessment of safety, tolerability, pharmacokinetics, and early efficacy signals in adult patients.…
08 May 2026 NCT06618287
● Recruiting Phase III Oncology
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
Treatment being tested: Camizestrant (a selective estrogen receptor degrader) versus standard endocrine therapy in ER+/HER2- early breast cancer patients who have completed at least…
08 May 2026 NCT05774951
● Recruiting Respiratory / COPD / Asthma
Closed-loop TMS for Tremor
What is being tested: Phase-locked transcranial magnetic stimulation (TMS) delivered in synchronisation with tremor oscillations as a non-invasive treatment approach for tremor in Essential…
08 May 2026 NCT07574164
● Recruiting Respiratory / COPD / Asthma
Using Mentalization Based Therapy to Support Children and Adolescents Referred to Specialist Mental Health Services in the NHS for Aggressive and/or Violent Behaviour
What is being tested: The MICA Study evaluates the effectiveness of mentalization-based therapy (MBT)—a psychological intervention that helps young people understand their own thoughts,…
08 May 2026 NCT07091721
● Recruiting Phase II Rheumatology
A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn’s Disease
Drug being tested: Icotrokinra, a novel therapeutic agent, is being evaluated for its efficacy and safety profile in treating moderately to severely active Crohn's…
08 May 2026 NCT07196722
● Recruiting Phase III Rheumatology
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
What is being tested: Risankizumab pharmacokinetics (how the drug moves through the body), safety, and efficacy in paediatric patients with ulcerative colitis, extending evidence…
08 May 2026 NCT07071519
● Recruiting Oncology
A Study of Clinical Outcomes in Participants With EGFR Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) in a Real-World Setting
What is being tested: Real-world clinical outcomes and effectiveness of amivantamab-containing treatment regimens in patients with EGFR-mutated advanced non-small cell lung cancer, moving beyond…
08 May 2026 NCT07230691
● Recruiting Cardiology / Cardiovascular
Distribution of Cell-cell Junction Proteins in Arrhythmic Disorders
What is being tested: The distribution and function of cell-cell junction proteins in heritable cardiac disorders that predispose to sudden cardiac death, investigating how…
08 May 2026 NCT04257994
● Recruiting Cardiology / Cardiovascular
AIC Genotyping Study
What is being tested: Genetic variants within a targeted dilated cardiomyopathy (DCM) gene panel are being analysed to identify and characterise genetic differences between…
08 May 2026 NCT07574697
● Recruiting Phase IV Cardiology / Cardiovascular
Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation
What is being tested: Monotherapy with P2Y12 inhibitors (clopidogrel, prasugrel, or ticagrelor) alone versus dual antiplatelet therapy or anticoagulant-antiplatelet combinations in atrial fibrillation patients…
08 May 2026 NCT05955365
● Recruiting Cardiology / Cardiovascular
Personalised Ablation Strategies in AF
What is being tested: Personalised ablation strategies for atrial fibrillation that move beyond standard one-size-fits-all approaches to customise treatment based on individual patient characteristics…
08 May 2026 NCT05633303
● Recruiting Cardiology / Cardiovascular
A Study of Clinical Outcomes in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) Treated With T-cell Redirectors Outside of Clinical Trials
What is being tested: Real-world clinical outcomes and safety data for two T-cell redirector therapies (teclistamab and talquetamab) in patients with relapsed/refractory multiple myeloma…
08 May 2026 NCT06285318
● Recruiting Cardiology / Cardiovascular
Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol
What is being tested: A co-designed sedation protocol to optimise pain and sedation management in critically ill adult patients receiving extracorporeal membrane oxygenation (ECMO)…
08 May 2026 NCT07032987
● Recruiting Cardiology / Cardiovascular
The PERSEVERE Study
What is being tested: The FlowTriever System (a mechanical thrombectomy device) versus standard care (anticoagulation ± thrombolysis) for treating high-risk pulmonary embolism, evaluating its…
08 May 2026 NCT06588634
● Recruiting Cardiology / Cardiovascular
PERIODONTAL HEALTH IN PATIENTS ACUTELY ADMITTED FOR MYOCARDIAL INFARCTION: A CASE CONTROL STUDY
What is being tested: The association between periodontal (gum) disease and acute myocardial infarction, investigating whether poor oral health is a risk factor or…
08 May 2026 NCT04719026
● Recruiting Phase III Oncology
A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)
What is being tested: A triple combination therapy of bleximenib plus venetoclax and azacitidine (VEN+AZA) compared to placebo with VEN+AZA alone in newly diagnosed…
08 May 2026 NCT06852222
● Recruiting Phase I Oncology
A Study of 14C-Bleximenib (Radiolabeled) in Participants With Acute Leukemia
What is being tested: Pharmacokinetic and metabolic profiling of radiolabeled bleximenib using radioactive carbon-14 tracing to determine absorption, metabolism, and excretion pathways in acute…
08 May 2026 NCT07295951
● Recruiting Phase I Oncology
A Phase I/II Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
Drug Being Tested: AZD4512, a novel investigational agent, is being evaluated as monotherapy or in combination with established anticancer agents in patients with relapsed/refractory…
08 May 2026 NCT07123454
● Recruiting Phase I Oncology
A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer
Drug being tested: UCB4594 is a novel monoclonal antibody undergoing first-in-human Phase I/II evaluation, designed to target a specific protein implicated in advanced cancer…
08 May 2026 NCT06380816
active not recruiting Phase III Oncology
Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
New drug sacituzumab govitecan compared to standard chemotherapy docetaxel for advanced lung cancer.
07 May 2026 NCT05089734
● Recruiting
CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
Registry tracking real-world outcomes in patients receiving catheter-based mitral valve replacement across multiple countries.
07 May 2026 NCT04688190
active not recruiting Respiratory / COPD / Asthma
Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS
COPD patients switching to heated tobacco showed improvements in cough, breathing, and lung function compared to continuing cigarettes.
07 May 2026 NCT07108166
● Recruiting
Vercise™ DBS Dystonia Prospective Study
Boston Scientific's Vercise deep brain stimulation improves dystonia symptoms in real-world clinical practice.
07 May 2026 NCT02686125
● Recruiting Neurology
Closed-loop TMS for Tremor
Phase-locked brain stimulation may reduce tremor in essential tremor and Parkinson's disease patients when timed to suppress tremor cycles.
07 May 2026 NCT07574164
● Recruiting Phase II
A Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization
New antibody treatment tested to prevent lung flare-ups in bronchiectasis patients with chronic bacterial infection.
07 May 2026 NCT07088926
● Recruiting Phase I / Phase II Oncology
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
Trial testing safety and early effectiveness of BMS-986507 combined with other drugs in adults with advanced cancer.
07 May 2026 NCT06618287
active not recruiting Phase II / Phase III Oncology
IoN- Is Ablative Radio-iodine Necessary for Low Risk Differentiated Thyroid Cancer Patients
Study testing whether radioactive iodine treatment is needed after surgery for low-risk thyroid cancer patients.
07 May 2026 NCT01398085
● Recruiting Oncology
SpaceOAR Post-Market Registry Study
Registry study tracking short and long-term safety of rectal spacers used with radiotherapy for prostate cancer in UK and French patients.
07 May 2026 NCT07300631
● Recruiting Phase III
Study of Oral Deucrictibant XR Tablet for Prophylaxis and Deucrictibant IR Capsule for On-Demand Treatment of Angioedema Attacks in Adults With Acquired Angioedema Due to C1 Inhibitor Deficiency
Trial testing oral deucrictibant tablets to prevent and treat angioedema attacks in adults with C1 inhibitor deficiency.
07 May 2026 NCT07266805
● Recruiting Cardiology / Cardiovascular
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
Medtronic reviewed how long cardiac devices last and how often they fail in routine clinical practice.
07 May 2026 NCT00271180
● Recruiting Infectious Disease
Fatigue in Lupus Intervention Programmes (FLIP)
Virtual group fatigue management programme may reduce fatigue impact in lupus patients better than booklet alone.
07 May 2026 NCT06308770
● Recruiting Phase III
Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE
Long-term study showing a daily tablet (deucrictibant) safely prevents angioedema attacks in teenagers and adults with hereditary angioedema.
07 May 2026 NCT06679881
active not recruiting Phase III Oncology
Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)
Enzalutamide plus leuprolide safely improved outcomes in high-risk prostate cancer patients who progressed after surgery or radiotherapy.
07 May 2026 NCT02319837