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Trial Radar

1003 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

1003 recruiting AI clinical summaries
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Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

active not recruiting Phase I / Phase II
INCB000928 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Anemia Due to Myeloproliferative Disorders
Trial testing INCB000928 alone or with ruxolitinib to treat anemia in myelofibrosis patients, assessing safety and effectiveness.
14 May 2026 NCT04455841
● Recruiting Phase I Respiratory / COPD / Asthma
A Two-part Study to Investigate the Effects in Adults of Two Doses of Golexanolone in Patients With Primary Biliary Cholangitis (PBC) With Fatigue and Cognitive Dysfunction
The present phase 1b/2 randomised, double-blind, placebo-controlled, two-part study is designed to evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of two dose…
14 May 2026 NCT07304843
● Recruiting Phase I Oncology
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
The purpose of this study is to assess the safety and efficacy of surovatamig (formerly AZD0486) administered as monotherapy or in combination with other…
14 May 2026 NCT06564038
active not recruiting Phase I Oncology
Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene)
Trial testing increasing doses of zongertinib tablet in advanced cancer with HER2 gene changes, then evaluating tumour response at tolerated dose.
13 May 2026 NCT04886804
● Recruiting Phase I Oncology
A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)
What is being tested: Raludotatug deruxtecan (MK-5909-003), a novel targeted therapy being investigated for treating relapsed high-grade serous ovarian cancer—a particularly aggressive form that…
13 May 2026 NCT06843447
● Recruiting Phase I
A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)
Early-stage trial testing new oral JAK2 inhibitor in myelofibrosis patients who failed previous JAK inhibitor treatment.
12 May 2026 NCT06343805
active not recruiting Phase I Oncology
Ascending Doses of Ceralasertib in Combination With Chemotherapy and/or Novel Anti Cancer Agents
Early-stage trial testing increasing doses of ceralasertib combined with chemotherapy and immunotherapy drugs in advanced cancer patients.
12 May 2026 NCT02264678
● Recruiting Phase I
Safety, Tolerability and Pharmacokinetics of AZD1613 in Adults With Autosomal Dominant Polycystic Kidney Disease
Drug being tested: AZD1613 is undergoing evaluation for safety, tolerability, and pharmacokinetics via subcutaneous or intravenous administration in adults with autosomal dominant polycystic kidney…
12 May 2026 NCT07228364
● Recruiting Phase I Oncology
Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)
Treatment Being Tested: Combination therapies (including pembrolizumab with investigational agents) for refractory renal cell carcinoma in patients with recurrent disease during or after anti-PD-(L)1…
12 May 2026 NCT07049926
● Recruiting Phase I Oncology
ACTinium in Castrate-RESistant Prostate Cancer After LUTEtium
What is being tested: Actinium-225 (a targeted alpha particle therapy) in patients with advanced metastatic castration-resistant prostate cancer who have previously received Lutetium-177 treatment,…
08 May 2026 NCT07414940
● Recruiting Phase I Oncology
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
Treatment Being Tested: BMS-986507 in combination regimens for advanced solid tumors, with assessment of safety, tolerability, pharmacokinetics, and early efficacy signals in adult patients.…
08 May 2026 NCT06618287
● Recruiting Phase I Oncology
A Study of 14C-Bleximenib (Radiolabeled) in Participants With Acute Leukemia
What is being tested: Pharmacokinetic and metabolic profiling of radiolabeled bleximenib using radioactive carbon-14 tracing to determine absorption, metabolism, and excretion pathways in acute…
08 May 2026 NCT07295951
● Recruiting Phase I Oncology
A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer
Drug being tested: UCB4594 is a novel monoclonal antibody undergoing first-in-human Phase I/II evaluation, designed to target a specific protein implicated in advanced cancer…
08 May 2026 NCT06380816
● Recruiting Phase I Oncology
A Phase I/II Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
Drug Being Tested: AZD4512, a novel investigational agent, is being evaluated as monotherapy or in combination with established anticancer agents in patients with relapsed/refractory…
08 May 2026 NCT07123454
● Recruiting Phase I / Phase II Oncology
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
Trial testing safety and early effectiveness of BMS-986507 combined with other drugs in adults with advanced cancer.
07 May 2026 NCT06618287
active not recruiting Phase I / Phase II
Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)
Testing combination immunotherapy and targeted drugs in newly diagnosed advanced kidney cancer to assess safety and effectiveness.
06 May 2026 NCT04626479
active not recruiting Phase I / Phase II
Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B/KEYMAKER-U03)
Testing combined immunotherapy and targeted drugs in patients with advanced kidney cancer who've had previous treatments.
06 May 2026 NCT04626518
● Recruiting EARLY_PHASE1 Respiratory / COPD / Asthma
Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic Fibrosis
What is being tested: Linaclotide, a guanylate cyclase-C agonist currently licensed for constipation and IBS-C, is being evaluated as a potential treatment for cystic…
06 May 2026 NCT07569419
● Recruiting Phase I Cardiology / Cardiovascular
A Study to Evaluate the Safety and Pharmacokinetics of Regadenoson in Pediatric Patients
What is being tested: Safety, tolerability, and pharmacokinetics of regadenoson (a vasodilator) administered as a single dose during cardiac magnetic resonance (CMR) stress testing…
06 May 2026 NCT04604782
active not recruiting Phase I / Phase II
ACP-196 (Acalabrutinib), a Novel Bruton Tyrosine Kinase (BTK) Inhibitor, for Treatment of Chronic Lymphocytic Leukemia, Richter’s Syndrome or Prolymphocytic Leukemia
A new blood cancer drug (acalabrutinib) is being tested for safety and effectiveness in treating chronic lymphocytic leukaemia.
05 May 2026 NCT02029443
● Recruiting Phase I Oncology
A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)
What is being tested: A combination immunotherapy of BNT326 and BNT327 in a dose-finding study to establish safety and efficacy in advanced/metastatic NSCLC across…
05 May 2026 NCT07111520
● Recruiting Phase I Oncology
Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies
What is being tested: AZD9574 is being evaluated as both a standalone treatment and in combination with established anti-cancer agents, with assessment of safety,…
05 May 2026 NCT05417594
● Recruiting Phase I Oncology
A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors
What is being tested: GDC-7035, a novel investigational agent, is undergoing first-in-human evaluation for safety, pharmacokinetics, and anti-cancer activity both as monotherapy and in…
04 May 2026 NCT06619587
● Recruiting Phase I Oncology
First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors
This is the first clinical trial of IDRX-42. The study is designed to evaluate the safety, tolerability, PK, and preliminary antitumor activity of IDRX-42…
04 May 2026 NCT05489237
● Recruiting Phase I Oncology
Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma
The goal of this clinical trial is to first define the Safety and Optimal Biological Dose (OBD) of study drug TGX-007 and to then…
04 May 2026 NCT07346144
● Recruiting Phase I Oncology
A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs
What is being tested: AZD9750, a novel investigational agent, is being evaluated as monotherapy and in combination with saruparib (a PARP inhibitor) in metastatic…
01 May 2026 NCT07336446
● Recruiting Phase I Neurology
A Study of AZD0120 in Autoimmune Diseases
What is being tested: AZD0120, a dual-targeting CAR+ T-cell therapy that simultaneously targets BCMA and CD19, is being evaluated for safety and tolerability in…
01 May 2026 NCT07295847
● Recruiting Phase I Cardiology / Cardiovascular
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
What is being tested: FT819, a novel therapeutic agent targeting B-cell activity, is being evaluated for safety, pharmacokinetics, and anti-B-cell efficacy in patients with…
01 May 2026 NCT06308978
● Recruiting Phase I Oncology
Clinical Study to Assess the Safety and Efficacy of the SpectraCure P18 System
What is being tested: The SpectraCure P18 System combined with verteporfin (a photosensitizer) is being evaluated for safety, efficacy, and optimal dosing parameters in…
01 May 2026 NCT03067051
● Recruiting Phase I Dermatology
A 3-part Study of SYX-5219 in Healthy Volunteers and Participants With Atopic Dermatitis
Early-stage trial testing new drug SYX-5219 for safety and effectiveness in healthy people and atopic dermatitis patients.
30 Apr 2026 NCT07558668
● Recruiting Phase I Oncology
LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve
What is being tested: EG-70 is an intravesical immunotherapy being evaluated for safety and efficacy in non-muscle invasive bladder cancer (NMIBC), with a Phase…
30 Apr 2026 NCT04752722
● Recruiting Phase I Respiratory / COPD / Asthma
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
What is being tested: LTP001 is a novel investigational treatment being evaluated in a two-part study: Part A assesses safety and tolerability in healthy…
29 Apr 2026 NCT06649110
● Recruiting Phase I Respiratory / COPD / Asthma
A Study of GSK4527363 in Healthy Participants, Systemic Lupus Erythematosus (SLE) Participants, Healthy Chinese, and Japanese Participants and CTD-ILD Participants
GSK4527363 is a novel investigational agent being evaluated for safety, tolerability, and pharmacokinetic/pharmacodynamic properties across healthy volunteers and patients with SLE and connective tissue…
29 Apr 2026 NCT06576271
● Recruiting Phase I Oncology
A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)
Treatment being tested: Investigational agents administered alone or in combination with pembrolizumab (a PD-1 inhibitor) in patients with PD-1/L1-refractory urothelial carcinoma, addressing an unmet…
29 Apr 2026 NCT05562830
active not recruiting Phase I Oncology
A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer
Trial testing immune-boosting antibodies plus cetuximab for advanced head and neck cancer patients who've failed standard treatment.
28 Apr 2026 NCT05249426
active not recruiting Phase I Rheumatology
A Study to Test How Well BI 3000202 is Tolerated by People With Type 1 Interferonopathies
Drug BI 3000202 safety and tolerability trial in adults with type 1 interferonopathies including AGS, COPA, and FCL syndromes.
28 Apr 2026 NCT06878365
● Recruiting Phase I Diabetes / Metabolic
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
A new weight loss drug (AZD1043) is being tested for safety and effectiveness in overweight and obese adults.
27 Apr 2026 NCT07511205
● Recruiting Phase I / Phase II
A Study of Roginolisib in Combination With Ruxolitinib in Patients With Myelofibrosis (MF) Who Are Unresponsive to JAK Inhibitors
Testing whether adding roginolisib to ruxolitinib safely improves outcomes in myelofibrosis patients who haven't responded to JAK inhibitors alone.
27 Apr 2026 NCT06887803
● Recruiting Phase I / Phase II
Study of KITE-363 or KITE-753 in Participants With Relapsed and/or Refractory B-cell Lymphoma
Trial testing two new cell therapies (KITE-363 and KITE-753) for B-cell lymphoma that hasn't responded to standard treatment.
24 Apr 2026 NCT04989803
active not recruiting Phase I / Phase II Oncology
A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer
Trial testing durvalumab combinations versus standard chemotherapy in patients with advanced triple negative breast cancer.
24 Apr 2026 NCT03742102
● Recruiting Phase I
A Study to Investigate Andexanet Dosing and the Interaction Between Andexanet and Subsequent Enoxaparin in Healthy Participants
Andexanet alfa dosing study examining how it interacts with subsequent enoxaparin treatment in healthy volunteers.
24 Apr 2026 NCT07312851
active not recruiting Phase I
Multi-modular Chimeric Antigen Receptor Targeting GD2 in Neuroblastoma
A trial testing a new engineered cell therapy for children with difficult-to-treat neuroblastoma, focusing on safety and feasibility.
24 Apr 2026 NCT05990751
active not recruiting Phase I Infectious Disease
COVID-19 Omicron BA.5 Subvariant Dose Finding Infection Study
Researchers tested different doses of Omicron BA.5 virus in vaccinated volunteers to find the optimal dose for future COVID vaccine studies.
24 Apr 2026 NCT06478420
● Recruiting Phase I Oncology
KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortumab Vedotin and Pembrolizumab in People With Urothelial Cancer (MK-3475-04D/KEYMAKER-U04)
What is being tested: Novel treatment combinations pairing enfortumab vedotin with pembrolizumab, investigating whether additional agents can improve outcomes in locally advanced or metastatic…
24 Apr 2026 NCT07232602
● Recruiting Phase I Oncology
Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors
What is being tested: GTAEXS617 (REC-617), a novel therapeutic agent, is being evaluated for safety, tolerability, pharmacokinetics, and anti-tumor activity in patients with advanced…
23 Apr 2026 NCT05985655
● Recruiting Phase I Oncology
Study of STP938 in Advanced Solid Tumours
What is being tested: STP938 is an investigational drug being evaluated in a Phase 1 dose escalation and safety expansion study as a monotherapy…
23 Apr 2026 NCT06297525
● Recruiting Phase I Oncology
Study for AZD4360 in Participants With Advanced Solid Tumours
What is being tested: AZD4360, a novel therapeutic agent, is being evaluated for safety, tolerability, pharmacokinetics, immunogenicity, and preliminary efficacy in patients with advanced…
23 Apr 2026 NCT06921928
● Recruiting Phase I / Phase II
Safety, Tolerability, PK and PD of ADX-038 in Healthy Participants and Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients
ADX-038, a new drug for rare blood disorder PNH, was tested for safety and effectiveness in healthy people and patients.
22 Apr 2026 NCT05876312
● Recruiting Phase I Neurology
An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
Treatment being tested: AZD0120, a dual-targeting CAR-T cell therapy designed to target both BCMA and CD19 on B cells, being evaluated for safety and…
22 Apr 2026 NCT07224373
● Recruiting Phase I Oncology
A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.
Drug Being Tested: NDI-219216, a novel investigational agent being evaluated for safety, tolerability, and efficacy in patients with advanced solid tumours through a phased…
22 Apr 2026 NCT06898450