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Clinical Trial ● Currently Recruiting Phase I NCT07511205

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity. — Recruiting • Phase I • Diabetes /…

📅 27 Apr 2026 ⏱ 1 min read
Currently Recruiting
This trial is actively seeking participants in the UK. Discuss eligibility with your patient before referring.
Status
Currently Recruiting
Phase
Phase I
NCT ID
NCT07511205
Start
2026-03-30
Completion
2027-03-15
ClinicaliQ Trial Snapshot
  • A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity. — Recruiting • Phase I • Diabetes / Metabolic • NCT07511205.
  • A new weight loss drug (AZD1043) is being tested for safety and effectiveness in overweight and obese adults.

Verify eligibility, endpoints and current status on the original ClinicalTrials.gov registry before acting on this summary.

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What This Trial Is Studying

The purpose of the study is to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of AZD1043 following single and multiple ascending doses in healthy adult participants living with overweight and/or obesity, including participants of Japanese and Chinese descent. Conditions: Healthy Participants, Obesity Interventions: AZD1043, Placebo Lead Sponsor: AstraZeneca Planned Enrollment: 104 participants

Full Trial Details
View this trial on the source registry
Eligibility criteria, protocol, and results when available
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Related Clinical Intelligence

Guidelines, Drug Science, safety briefs and education connected to this trial area.

Guideline
Tirzepatide for Managing Overweight and Obesity (NICE TA1026)
Diabetes / Metabolic · 27 Mar 2026
Prescribe tirzepatide to adults with BMI ≥35 kg/m² or BMI 30–34.9 kg/m² with weight-related comorbidities, initiating treatment in specialist weight management services…
View guideline →
Guideline
Semaglutide for Managing Overweight and Obesity (NICE TA875)
Diabetes / Metabolic · 27 Mar 2026
Initiate semaglutide only in specialist obesity services or via shared care with clear primary-secondary care protocols for adults with BMI ≥30 kg/m²…
View guideline →
Clinical Brief
New drug to stop ‘Ozempic butt’ muscle loss side effect of obesity jabs
Diabetes / Metabolic · BBC Health · 08 Jun 2026
Weight loss from GLP-1 receptor agonists results in approximately 33% muscle loss alongside fat loss, necessitating clinical attention to body composition changes…
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Clinical Brief
New light shed on who benefits most from weight-loss jabs
Diabetes / Metabolic · BBC Health · 08 Apr 2026
People who carry variations in two genes linked to appetite and digestion can lose more weight when taking drugs to treat obesity,…
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Clinical Brief
Why weight-loss jabs work better for some people than others
Diabetes / Metabolic · BBC Health · 10 Apr 2026
Genetic variations in appetite and digestion genes predict differential weight-loss responses to GLP-1 receptor agonists (Wegovy, Mounjaro), suggesting personalised medicine approaches may…
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Clinical Brief
Weight-loss jabs will be offered on NHS for people at risk of further heart attacks
Cardiology / Cardiovascular · BBC Health · 31 Mar 2026
GLP-1 receptor agonists (weight-loss jabs) will now be offered on NHS to over 1 million people in England at high cardiovascular risk,…
View brief →