ClinicaliQ Trial Snapshot
- An Open-label Study of AZD0120 in Adults With Multiple Sclerosis — Recruiting • Phase I • Neurology • NCT07224373.
- Treatment being tested: AZD0120, a dual-targeting CAR-T cell therapy designed to target both BCMA and CD19 on B cells, being evaluated for safety and tolerability in adults with Multiple Sclerosis in this Phase 1b open-label study.
- Patient eligibility overview: Adult participants with Multiple Sclerosis are enrolled in this multi-center trial; specific eligibility criteria would typically include disease confirmation, age requirements, and adequate organ function, though detailed inclusion/exclusion criteria are not specified in this summary.
Use This Page For
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying
This trial is a Phase 1b, open-label, multi-center, clinical study of AZD0120, a BCMA/CD19 dual targeting CAR+ T-cell therapy, to evaluate the safety and tolerability in adult participants with Multiple Sclerosis.
Eligibility Snapshot
- Participants are eligible to be included in the study only if all of the following criteria apply: Age 1. Age ≥ 18-years-old to ≤ 60-years-old at the time of consent Type of Participant and Disease Characteristics 2. Written informed consent in accordance with federal, local, and institutional guidelines 3. Adequate physiological function and reserve at screening RMS Cohort Specific Inclusion Criteria 4. Diagnosis of RMS according to the 2024 McDonald Criteria (Montalban et al 2025) or diagnosis of relapsing, active SPMS according to Lublin et al 2014.
- Participants should have an EDSS of ≤ 6.5 at screening. 6. Evidence of active disease (clinical relapses and MRI activities within 2 years prior to screening), or intolerance, while on a high efficacy disease-modifying therapy for ≥ 6 months. PMS Cohort Specific Inclusion Criteria 7. Diagnosis of PPMS according to the 2024 McDonald Criteria (Montalban et al 2025) or non-relapsing SPMS according to Lublin et al 2014.
- Participants must have an EDSS of ≥ 3.0 and ≤ 6.5 at screening. 9. Inadequate response ≥ 1 heDMT with ≥ 6 months treatment or intolerance.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.