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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

1003 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

1003 recruiting AI clinical summaries
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Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

active not recruiting Phase I / Phase II Oncology
Durvalumab and Tremelimumab for Pediatric Malignancies
Study testing safe doses of two immunotherapy drugs in children with advanced cancers, then checking if they work.
21 Apr 2026 NCT03837899
● Recruiting Phase I Oncology
AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies.
This study is designed to evaluate the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy following oral administration of AZD3470 as a monotherapy, and in…
21 Apr 2026 NCT06137144
active not recruiting Phase I / Phase II
Safety and Tolerability of BION-1301 in Healthy Volunteers and Adults With IgA Nephropathy (IgAN)
BION-1301 was tested for safety and tolerability in healthy people and IgA kidney disease patients.
20 Apr 2026 NCT03945318
● Recruiting Phase I Oncology
A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and preliminary activity of RO7656594 in participants with advanced or metastatic prostate…
20 Apr 2026 NCT05800665
● Recruiting Phase I Oncology
A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and activity of single-agent divarasib or combined with other anti-cancer therapies in…
20 Apr 2026 NCT05789082
● Recruiting Phase I Oncology
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
This study will test the safety of a drug called PF-08046054/SGN-PDL1V alone and with pembrolizumab in participants with solid tumors. It will also study…
20 Apr 2026 NCT05208762
● Recruiting Phase I Oncology
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma
This study will evaluate the safety, efficacy, and pharmacokinetics of mosunetuzumab or glofitamab in combination with CELMoDs (CC-220 and/or CC-99282) in participants with B-cell…
20 Apr 2026 NCT05169515
● Recruiting Phase I Oncology
A Phase I Study of BAY3498264 Given Together With Sotorasib in Participants Who Have Advanced Solid Cancers With Specific Genetic Changes Called KRASG12C Mutation
Researchers are looking for a better way to treat people who have advanced solid cancers with a KRASG12C mutation. Sotorasib is a drug that…
20 Apr 2026 NCT06659341
● Recruiting Phase I Oncology
Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer
The study will be conducted in 4 parts and will commence with dose escalation of VIR-5500 as a monotherapy (Part 1), followed by combination…
20 Apr 2026 NCT05997615
active not recruiting Phase I Oncology
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
A study testing a new oral drug (MOMA-313) in patients with advanced cancers, assessing safety, dosage, and effectiveness alone or combined.
17 Apr 2026 NCT06545942
● Recruiting Phase I
A Study to Evaluate ALN-4285 in Adult Healthy Volunteers
ALN-4285 safety, tolerability, and how the body processes single doses tested in healthy adults.
17 Apr 2026 NCT07295717
● Recruiting Phase I / Phase II
A Study of Pirtobrutinib in Participants With Immune Thrombocytopenia
Phase 1/2 trial testing oral pirtobrutinib for immune thrombocytopenia, evaluating safety, tolerability, and effectiveness at different doses.
17 Apr 2026 NCT06721013
● Recruiting Phase I Oncology
A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment BNT327 and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer
Treatment Being Tested: BNT314 (immunotherapy) combined with BNT327 (immune checkpoint inhibitor) and chemotherapy in a randomised, multi-site design to evaluate efficacy and safety in…
17 Apr 2026 NCT07079631
● Recruiting Phase I Oncology
A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer
Treatment being tested: BNT323 combined with BNT327 (both investigational agents) to determine optimal dosing, safety profile, and clinical efficacy in advanced breast cancer across…
17 Apr 2026 NCT06827236
● Recruiting Phase I Oncology
A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
What is being tested: BNT329, an investigational drug designed to target CA19-9-expressing advanced solid tumors, with primary focus on establishing safety profile and optimal…
17 Apr 2026 NCT07186842
● Recruiting Phase I Oncology
A First-in-human Study to Learn How Safe BAY 3713372 is and How it Works in Participants With MTAP-deleted Solid Tumors
BAY 3713372 is a novel PRMT5 inhibitor being tested in a first-in-human trial to treat MTAP-deleted solid tumors, designed to selectively target cancer cells…
17 Apr 2026 NCT06914128
● Recruiting Phase I Cardiology / Cardiovascular
A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma
The purpose of this study is to assess the safety, tolerability, and efficacy of sonrotoclax as monotherapy and in various combinations in patients with…
16 Apr 2026 NCT04973605
● Recruiting Phase I Neurology
First in Human Safety and Ease of Use Assessment of 400mg Progesterone Callavid in Women With Luteal Phase Insufficiency
Early-stage trial testing safety and user experience of new vaginal progesterone device versus standard pessaries in women with luteal phase insufficiency.
15 Apr 2026 NCT07136922
● Recruiting Phase I Oncology
Investigating SX-682 in Combination With Apalutamide in Metastatic Castration-resistant Prostate Cancer
ASpiRE will investigate the effect of the drug SX-682 in combination with Apalutamide in men suffering from metastatic castration-resistant prostate cancer (mCRPC).
15 Apr 2026 NCT07002320
● Recruiting Phase I Oncology
A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer
This study aims to investigate the combination of BNT324, a B7-H3 antibody-drug conjugate (ADC) with BNT327, a programmed death-ligand 1 (PD-L1) and vascular endothelial…
15 Apr 2026 NCT06892548
● Recruiting Phase I Neurology
An Open-label Study to Investigate ECUR-506 in Male Babies Less Than 9 Months of Age With Neonatal Onset OTC Deficiency
Ornithine Transcarbamylase (OTC) deficiency, the most common urea cycle disorder, is an inherited metabolic disorder caused by a genetic defect in a liver enzyme…
15 Apr 2026 NCT06255782
● Recruiting Phase I Cardiology / Cardiovascular
A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies
Study consists of two main parts to explore BGB-16673 recommended dosing, a Phase 1 monotherapy dose finding comprised of monotherapy dose escalation and monotherapy…
15 Apr 2026 NCT05006716
● Recruiting Phase I / Phase II
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Early-stage trial testing a new oral drug (nuvisertib) for safety and effectiveness in myelofibrosis patients.
14 Apr 2026 NCT04176198
● Recruiting Phase I Oncology
A Phase 1/1b Study of IAM1363 in HER2 Cancers
This is a Phase 1/1b open-label, multi-center dose escalation and dose optimization study designed to evaluate the safety and preliminary efficacy of IAM1363 in…
14 Apr 2026 NCT06253871
● Recruiting Phase I Oncology
Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection
To determine the dose, safety, radiation dosimetry and efficacy of 177Lu-rhPSMA-10.1 in participants with PSMA-expressing metastatic castrate resistant prostate cancer.
14 Apr 2026 NCT05413850
● Recruiting Phase I Oncology
Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer
This is a Phase 1/2, open-label, randomized, dose finding and dose expansion study to evaluate the safety, preliminary efficacy, and PK of gedatolisib in…
14 Apr 2026 NCT06190899
● Recruiting Phase I Oncology
A Study of Pasritamig (JNJ-78278343) in Combination With JNJ-86974680 for Treatment of Prostate Cancer
The purpose of this study is to identify the recommended phase 2 combination dose (RP2CD) of Pasritamig in combination with JNJ-86974680 in Part 1…
14 Apr 2026 NCT07319871
● Recruiting Phase I Oncology
A Study of JNJ-78278343 in Combination With JNJ-95298177 for Treatment of Prostate Cancer
The purpose of this study is to identify the recommended phase 2 combination dose (RP2CD) of JNJ-78278343 in combination with JNJ-95298177 in Part 1…
14 Apr 2026 NCT07082920
● Recruiting Phase I Oncology
Study of INCB123667 in Subjects With Advanced Solid Tumors
This is an open-label, dose-escalation and dose-expansion study to determine the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy of INCB123667 when administered as monotherapy…
14 Apr 2026 NCT05238922
● Recruiting Phase I Oncology
An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01)
This is a two-part, Phase I/II, open-label, global, multicenter study assessing the safety and efficacy of the combination of tulmimetostat (DZR123) and JSB462 (luxdegalutamide)…
14 Apr 2026 NCT07206056
● Recruiting Phase I Oncology
Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
This first-in-human (FIH) study for BNT116 aims to establish the safety profile and a safe dose for BNT116 monotherapy as well as for BNT116…
14 Apr 2026 NCT05142189
active not recruiting Phase I Oncology
A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer
This trial compares different formulations of niraparib and abiraterone acetate to ensure they work similarly in men with advanced prostate cancer.
13 Apr 2026 NCT04577833
● Recruiting Phase I Respiratory / COPD / Asthma
NAL ER IPF Respiratory Function and Safety Study
What is being tested: Escalating doses of NAL ER (N-acetylcysteine extended-release) to evaluate its safety, tolerability, and effects on respiratory function in idiopathic pulmonary…
10 Apr 2026 NCT07036029
● Recruiting Phase I Oncology
A Study Assessing if it is Safe and Possible to Treat Brain Cancer Patients With Immunotherapy Before They Receive the Standard Treatment.
What is being tested: Neoadjuvant ipilimumab (an immune checkpoint inhibitor) administered before standard surgical treatment in newly diagnosed glioblastoma patients, evaluating both safety and…
10 Apr 2026 NCT07134842
● Recruiting Phase I Oncology
A Study of YL201 in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors
What is being tested: YL201 (an investigational cancer therapy) combined with atezolizumab (an immune checkpoint inhibitor) in a phase Ib/II dose escalation and expansion…
10 Apr 2026 NCT07407933
● Recruiting Phase I
Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]GRT6019
This study tracks how the body absorbs, breaks down and eliminates a single dose of an experimental drug called GRT6019.
09 Apr 2026 NCT07479745
● Recruiting Phase I
Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of ALXN2230 in Healthy Participants
ALXN2230 single injection tested for safety and tolerability in healthy volunteers.
09 Apr 2026 NCT07352423
active not recruiting Phase I / Phase II Oncology
GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors
GEN1042 antibody tested alone and combined with pembrolizumab, with or without chemotherapy, in patients with solid tumours.
08 Apr 2026 NCT04083599
● Recruiting Phase I Cardiology / Cardiovascular
Test-retest Study With [18F]FBB in Cardiac Amyloidosis
A study testing whether PET scans reliably detect amyloid buildup in hearts of patients with cardiac amyloidosis.
08 Apr 2026 NCT06790394
● Recruiting Phase I Oncology
A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors
A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced…
08 Apr 2026 NCT06188520
● Recruiting Phase I Oncology
Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer
Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer is Recruiting • Phase I • Oncology • NCT07181161. The…
08 Apr 2026 NCT07181161
● Recruiting Phase I Oncology
A Study to Evaluate the Safety, Tolerability, Preliminary Efficacy of KRC-01
A Study to Evaluate the Safety, Tolerability, Preliminary Efficacy of KRC-01 is Recruiting • Phase I • Oncology • NCT05570422. This is a seamless…
08 Apr 2026 NCT05570422
● Recruiting Phase I
Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ION464 Administered to Adults With Multiple System Atrophy (HORIZON)
Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ION464 Administered to Adults With Multiple System Atrophy (HORIZON) is Recruiting • Phase I •…
07 Apr 2026 NCT04165486
active not recruiting Phase I Oncology
A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors
A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors is Active Not Recruiting • Phase I • Oncology • NCT05571839. Review the…
07 Apr 2026 NCT05571839
● Recruiting Phase I Oncology
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors is…
07 Apr 2026 NCT06004245
● Recruiting Phase I Oncology
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors is Recruiting • Phase I • Oncology • NCT06131840. This clinical trial is studying…
07 Apr 2026 NCT06131840
● Recruiting Phase I Gastroenterology
Multiple Dose Study for a New Medication to Potentially Treat Liver Diseases
Multiple Dose Study for a New Medication to Potentially Treat Liver Diseases is Recruiting • Phase I • Gastroenterology • NCT06891365. The purpose of…
07 Apr 2026 NCT06891365
● Recruiting Phase I Oncology
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
A Study of Sigvotatug Vedotin in Advanced Solid Tumors is Recruiting • Phase I • Oncology • NCT04389632. This trial will look at a…
07 Apr 2026 NCT04389632
● Recruiting Phase I Oncology
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors is Recruiting • Phase I • Oncology •…
07 Apr 2026 NCT07090499
● Recruiting Phase I Oncology
Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer
Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer is Recruiting • Phase I • Oncology • NCT05386108.…
06 Apr 2026 NCT05386108