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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

1963 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

1963 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

● Recruiting Phase I Cardiology / Cardiovascular
A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)
Treatment being tested: Linvoseltamab, an experimental monoclonal antibody targeting serum amyloid A, is being evaluated for safety and efficacy in adults with relapsed or…
22 Jun 2026 NCT06292780
● Recruiting Phase I Oncology
A Study to Assess the Safety and Anti-Tumor Activity of REGN7945 in Combination With Linvoseltamab in Adult Participants With Relapsed/Refractory Multiple Myeloma
What is being tested: REGN7945 combined with linvoseltamab (REGN5458), two experimental bispecific antibodies, in adults with relapsed/refractory multiple myeloma; this is the first-in-human study…
22 Jun 2026 NCT06669247
● Recruiting Phase I Oncology
Study of AZD4956 as Monotherapy and in Combination With Anti-Cancer Agents in Participants With Advanced/Metastatic Homologous Recombination Deficient Solid Tumours
What is being tested: AZD4956, a novel investigational agent, is being evaluated as both a monotherapy and in combination with established anti-cancer treatments in…
18 Jun 2026 NCT07446855
● Recruiting Phase I Oncology
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
What is being tested: An umbrella trial evaluating multiple treatment combination regimens across seven cohorts in patients with metastatic or inoperable locally advanced breast…
18 Jun 2026 NCT03424005
● Recruiting Phase I Oncology
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
What is being tested: S241656 is a novel investigational agent being evaluated in a first-in-human trial as monotherapy and in combination with established anti-cancer…
18 Jun 2026 NCT05786924
● Recruiting Phase I
Phase 1 Study of ADX-626 in Healthy Participants
Early safety testing of new drug ADX-626 in healthy volunteers to check it's tolerable and how the body processes it.
17 Jun 2026 NCT07081503
● Recruiting Phase I Gastroenterology
A Phase 1/2, Open-Label, Single and Multiple Ascending Dose Study of CRMA-1001 in Adults With Chronic Hepatitis B
Drug being tested: CRMA-1001, a novel therapeutic agent undergoing Phase 1/2 evaluation for safety, tolerability, and efficacy in adults with chronic hepatitis B using…
17 Jun 2026 NCT07200193
● Recruiting Phase I Oncology
A Phase 1/2 Study of STP938 (Dencatistat) for Adult Subjects With Relapsed/Refractory B-Cell and T-Cell Lymphomas
Drug and Mechanism: STP938 (Dencatistat) is being tested as a monotherapy agent in a dose-escalation Phase 1 study followed by Phase 2 cohort expansion…
17 Jun 2026 NCT05463263
active not recruiting Phase I Oncology
A Study to Learn How Safe the Study Treatment Actinium-225-macropa-pelgifatamab (BAY3546828) is, How it Affects the Body, How it Moves Into, Through and Out of the Body, and About Its Anticancer Activity in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)
First-in-human trial testing safety, tolerability, and cancer-fighting activity of a new radioactive targeted treatment for advanced prostate cancer.
15 Jun 2026 NCT06052306
active not recruiting Phase I / Phase II Gastroenterology
Study to Test the Safety and How Well Patients With Severe Hemophilia A Respond to Treatment With BAY 2599023 (DTX 201), a Drug Therapy That Delivers a Healthy Version of the Defective Factor VIII Gene Into the Nucleus of Liver Cells Using an Altered, Non-infectious Virus (AAV) as a “Shuttle”
Gene therapy trial testing safety and effectiveness of BAY 2599023 for severe hemophilia A treatment.
15 Jun 2026 NCT03588299
● Recruiting Phase I
Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of LAI MMV055 Alone and in Combination With MMV371 in Healthy Participants
Testing two new long-acting injectable medicines alone and combined for safety, tolerability and how the body processes them in healthy volunteers.
15 Jun 2026 NCT07011511
active not recruiting Phase I / Phase II Oncology
Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer
Trial testing a new breast cancer drug (elacestrant) combined with five existing treatments to find safe doses and effectiveness.
12 Jun 2026 NCT05563220
● Recruiting Phase I Oncology
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
What is being tested: AMG 410, a novel KRAS-targeted agent, is being evaluated as monotherapy and in combination regimens for safety, tolerability, pharmacokinetics, and…
12 Jun 2026 NCT07094113
● Recruiting Phase I Oncology
Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma
Therapeutic Target: XmAb®819 is being tested as a potential treatment for advanced clear cell renal cell carcinoma (ccRCC), specifically in patients with relapsed or…
12 Jun 2026 NCT05433142
● Recruiting Phase I Oncology
Dose Determining Study of EXS73565 in Participants With Relapsed or Refractory B-Cell Malignancies
What is being tested: EXS73565 is an oral investigational agent being evaluated for safety, tolerability, pharmacokinetics, and antitumor activity in a dose-determining study in…
12 Jun 2026 NCT06980116
active not recruiting Phase I Oncology
Study to Evaluate Adverse Events, Change in Disease Activity, and How Oral ABBV-101 Moves Through the Body in Adult Participants With B-Cell Malignancies
Trial testing safety and effectiveness of oral ABBV-101 alone or combined with venetoclax in adults with relapsed/refractory non-Hodgkin's lymphoma.
09 Jun 2026 NCT05753501
● Recruiting Phase I Oncology
A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)
Trial testing loncastuximab tesirine combined with three other drugs in patients with hard-to-treat B-cell lymphoma to find safe, effective doses.
09 Jun 2026 NCT04970901
● Recruiting Phase I Oncology
A Study to Learn How Safe AZD6621 is, How Well it Works, and How it Moves Throughout the Body Over Time, in Adult Male Participants With Metastatic Prostate Cancer
What is being tested: AZD6621, an experimental therapeutic agent, is undergoing evaluation for safety, tolerability, pharmacokinetics, and efficacy in adult male patients with metastatic…
09 Jun 2026 NCT07192614
active not recruiting Phase I
Study of E7386 in Participants With Selected Advanced Neoplasms
A study testing an oral cancer drug (E7386) to find safe doses and assess side effects in patients with advanced cancers.
08 Jun 2026 NCT03264664
● Recruiting Phase I Neurology
A Phase I Study in Healthy Volunteers and Parkinson’s Disease (PD) Patients.
What is being tested: MTX325 is being evaluated as a potential disease-modifying treatment for Parkinson's Disease, assessed initially in healthy volunteers for safety and…
05 Jun 2026 NCT07630545
● Recruiting Phase I Cardiology / Cardiovascular
A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis
What is being tested: JNJ-79635322, a novel investigational agent, is undergoing dose escalation and safety characterization in patients with relapsed or refractory multiple myeloma…
05 Jun 2026 NCT05652335
● Recruiting Phase I Oncology
A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms
Drug Being Tested: JNJ-88549968, a novel therapeutic agent targeting CALR-mutated myeloproliferative neoplasms (MPNs), with the study establishing safety profile, recommended phase 2 dose, and…
05 Jun 2026 NCT06150157
active not recruiting Phase I / Phase II Diabetes / Metabolic
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
VX-264 trial tested a new drug's safety and effectiveness in type 1 diabetes patients.
04 Jun 2026 NCT05791201
● Recruiting Phase I Oncology
A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers
What is being tested: LY4584180, a novel investigational agent, is being evaluated for its safety, efficacy, pharmacokinetics, and pharmacodynamics in adults with relapsed or…
04 Jun 2026 NCT07226843
● Recruiting Phase I Oncology
A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types
Drug Being Tested: Farletuzumab ecteribulin (MORAb-202), a folate receptor alpha (FRα)-targeting antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells expressing this receptor.…
04 Jun 2026 NCT04300556
● Recruiting Phase I Oncology
TulmiSTAR-02: A Phase I/II Open-label Study of Tulmimetostat in Combination With Darolutamide vs. Darolutamide, and Tulmimetostat With Abiraterone in Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
What is being tested: Tulmimetostat (a novel STAT3 inhibitor) combined with either darolutamide or abiraterone, compared to darolutamide monotherapy, to assess safety, tolerability, and…
03 Jun 2026 NCT07190300
● Recruiting Phase I Oncology
Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors
What is being tested: AZD5335, an antibody-drug conjugate, is being evaluated both as a standalone treatment and combined with established anti-cancer agents to assess…
03 Jun 2026 NCT05797168
active not recruiting Phase I / Phase II Dermatology
Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)
Trial testing epcoritamab alone or combined with other drugs for B-cell non-Hodgkin lymphoma across ten treatment arms.
02 Jun 2026 NCT04663347
● Recruiting Phase I
Study of BHV-1400 in IgA Nephropathy
What is being tested: BHV-1400, a novel investigational treatment, is being evaluated for safety and tolerability in patients with IgA Nephropathy (IgAN), the most…
02 Jun 2026 NCT07054684
● Recruiting Phase I Cardiology / Cardiovascular
A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)
Being Tested: Surzetoclax, an oral agent, administered alone or combined with established subcutaneous/oral antimyeloma treatments, to evaluate safety profile and disease activity changes in…
02 Jun 2026 NCT06953960
● Recruiting Phase I Oncology
Pharmacokinetics and Safety Study of Pelabresib in Patients With Advanced Malignancies and Hepatic Impairment
What is being tested: Pelabresib pharmacokinetics and safety in patients with advanced malignancies, specifically comparing drug exposure and clearance between those with hepatic impairment…
02 Jun 2026 NCT07422610
● Recruiting Phase I Oncology
A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)
What is being tested: Pembrolizumab (an anti-PD-1 immunotherapy checkpoint inhibitor) is being evaluated for efficacy and safety in pediatric patients with advanced solid tumors,…
01 Jun 2026 NCT02332668
● Recruiting Phase I / Phase II
A Study of AAVB-039 in Participants With Stargardt Disease (STGD1)
Gene therapy injection for Stargardt disease shows safety and early effectiveness in patients with ABCA4 gene mutations.
29 May 2026 NCT07161544
active not recruiting Phase I / Phase II Oncology
A Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Englumafusp Alfa in Combination With Obinutuzumab and in Combination With Glofitamab Following a Pre-Treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-Cell Non-Hodgkin’s Lymphoma
Early-stage trial testing new cancer drug englumafusp alfa combined with existing treatments in patients with relapsed/refractory lymphoma.
29 May 2026 NCT04077723
● Recruiting Phase I Oncology
A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies
What is being tested: ZI-MA4-1, a novel therapeutic agent, is undergoing evaluation for safety, tolerability, and clinical efficacy in patients with advanced solid malignancies…
29 May 2026 NCT07613723
● Recruiting Phase I Neurology
A Study to Assess the Effects of ACI-24.060 in Alzheimer’s Disease and in Down Syndrome (ABATE Study)
What is being tested: ACI-24.060, an investigational therapeutic agent, is being evaluated for its safety, tolerability, immunogenicity, and pharmacodynamic effects in two distinct populations:…
29 May 2026 NCT05462106
active not recruiting Phase I / Phase II Oncology
A Study of Anvumetostat in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)
MTAPESTRY 101 Summary Trial testing anvumetostat drug alone and with chemotherapy in patients with MTAP-null cancers to find safe doses and effectiveness.
28 May 2026 NCT05094336
● Recruiting Phase I Cardiology / Cardiovascular
A Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma
What is being tested: A phase 1b/2 dose-escalation and expansion study evaluating mezigdomide (cereblon E3 ligase modulator) combined with elranatamab (GPRC5D-targeted bispecific antibody) to…
28 May 2026 NCT06988488
● Recruiting Phase I Oncology
A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.
What is being tested: [177Lu]Lu-NeoB, a novel radioligand therapeutic targeting GRPR-positive tumours, combined with capecitabine chemotherapy in a dose-escalation study to establish safe and…
27 May 2026 NCT06247995
● Recruiting Phase I Oncology
Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors
What is being tested: Zanzalintinib (a novel therapeutic agent) is being evaluated as monotherapy and in combination with immune checkpoint inhibitors (nivolumab ± ipilimumab)…
27 May 2026 NCT05176483
● Recruiting Phase I Oncology
FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC
What is being tested: TUB-040, a novel NaPi2b antibody-drug conjugate (ADC), is being investigated in a first-in-human trial to establish safety, tolerability, pharmacokinetics, and…
27 May 2026 NCT06303505
● Recruiting Phase I / Phase II
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
ETX101 gene therapy trial testing safety and effectiveness in infants and children with Dravet syndrome.
26 May 2026 NCT05419492
● Recruiting Phase I Cardiology / Cardiovascular
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
Drug being tested: CTX310 is undergoing Phase 1 evaluation in a single-arm, open-label design with ascending doses to establish safety and tolerability in adults…
26 May 2026 NCT07491172
● Recruiting Phase I Oncology
A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors
What is being tested: OKN4395, a novel investigational drug, is being evaluated as monotherapy and in combination with pembrolizumab (an established PD-1 checkpoint inhibitor)…
22 May 2026 NCT06789172
● Recruiting Phase I Oncology
A Study of DS9051b in Participants With Advanced or Metastatic Adrenocortical Carcinoma and Metastatic Castration-resistant Prostate Cancer
Drug being tested: DS9051b, a first-in-human (FIH) investigational agent, is being evaluated for safety, tolerability, and early efficacy signals in two aggressive malignancies: advanced/metastatic…
22 May 2026 NCT07189403
● Recruiting Phase I Oncology
Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)
Treatment being tested: Patritumab deruxtecan (MK-1022), a HER2-targeted antibody-drug conjugate, either alone or in combination with other anticancer agents in patients with HER2-positive unresectable…
22 May 2026 NCT06686394
● Recruiting Phase I Cardiology / Cardiovascular
A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments
What is being tested: Belantamab, an unconjugated antibody targeting BCMA (B-cell maturation antigen), is being evaluated as both a monotherapy and in combination regimens…
22 May 2026 NCT05714839
● Recruiting Phase I Oncology
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
Drug Being Tested: INBRX-109 is a first-in-human recombinant humanized tetravalent antibody targeting death receptor 5 (DR5), designed to trigger apoptosis in cancer cells through…
22 May 2026 NCT03715933
active not recruiting Phase I Oncology
A First-in-human Study to Learn How Safe the Study Drug BAY3375968, an Anti-CCR8 Antibody, is, When Given Alone or in Combination With Pembrolizumab, How it Affects the Body, How it Moves Into, Through, and Out of the Body, and to Find the Best Dose in Participants With Advanced Solid Tumors
Early-stage safety and dosage trial of new anti-CCR8 antibody BAY3375968 alone or combined with pembrolizumab in advanced solid tumours.
20 May 2026 NCT05537740
● Recruiting Phase I Respiratory / COPD / Asthma
A Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis
What is being tested: XTMAB-16, an investigational monoclonal antibody, is being evaluated in a phase 1b/2 study as a potential new treatment for pulmonary…
20 May 2026 NCT05890729