ClinicaliQ Trial Snapshot
- Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options — Active Not Recruiting • Phase I / Phase II • Oncology • NCT02650401.
- Entrectinib tested in children with advanced solid or brain tumours carrying specific gene fusions to find safe doses and effectiveness.
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What This Trial Is Studying
This is an open-label, Phase 1/2 multicenter dose escalation study in pediatric patients with relapsed or refractory extracranial solid tumors (Phase 1), with additional expansion cohorts (Phase 2) in patients with primary brain tumors harboring NTRK1/2/3 or ROS1 gene fusions, and extracranial solid tumors harboring NTRK1/2/3 or ROS1 gene fusions. Conditions: Solid Tumors, CNS Tumors Interventions: Entrectinib Lead Sponsor: Hoffmann-La Roche Planned Enrollment: 69 participants