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Trial Radar

1003 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

active not recruiting Phase III
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Thyroid Eye Disease
Satralizumab injection tested for treating thyroid eye disease by blocking inflammation.
14 May 2026 NCT06106828
● Recruiting Phase III
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
Trial testing whether brenipatide reduces alcohol use better than placebo in people with moderate-to-severe alcohol use disorder over 56 weeks.
14 May 2026 NCT07219966
active not recruiting Phase III Oncology
DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)
Tovorafenib compared to standard chemotherapy for treating children with low-grade brain tumours with RAF mutations.
14 May 2026 NCT05566795
● Recruiting Phase III Oncology
A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
This study will assess the effect of Dato-DXd in combination with osimertinib or Dato-DXd monotherapy versus platinum-based doublet chemotherapy in terms of progression-free survival…
14 May 2026 NCT06417814
● Recruiting Phase III Oncology
A Study to Evaluate the Benefit of Adding Durvalumab After Chemotherapy, Durvalumab and Surgery in Patients With Early-stage, Operable, Non-small Cell Lung Cancer.
ADOPT-lung is an international, multicentre, open-label randomised phase III trial. Protocol treatment consists of 3-4 cycles of neoadjuvant durvalumab in combination with platinum-based doublet…
14 May 2026 NCT06284317
● Recruiting Phase III Oncology
Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma
Multiple myeloma (MM) is a cancer of the blood's plasma cells. The cancer is typically found in the bones and bone marrow (the spongy…
14 May 2026 NCT06158841
● Recruiting Phase III Oncology
A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.
The study is a randomized, double-blind, placebo-controlled, multicenter, Phase III study, to evaluate efficacy, safety and tolerability of iptacopan in patients with AChR+ gMG…
14 May 2026 NCT06517758
active not recruiting Phase III
A Study of 2 Doses of Ritlecitinib in People 12 Years of Age and Older With Alopecia Areata
Trial comparing two doses of ritlecitinib (50mg vs 100mg daily) for treating severe alopecia areata in people aged 12+.
13 May 2026 NCT06873945
active not recruiting Phase III Oncology
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
T-DXd compared to T-DM1 for HER2-positive breast cancer with residual disease after chemotherapy.
13 May 2026 NCT04622319
active not recruiting Phase III Oncology
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
Venetoclax extension study collecting long-term safety data in patients continuing to benefit from treatment.
13 May 2026 NCT03844048
● Recruiting Phase III Gastroenterology
Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein
Treatment being tested: Fazirsiran, an investigational therapy designed to reduce liver fibrosis in patients with alpha-1 antitrypsin (AAT) deficiency-related liver disease, compared against placebo.…
13 May 2026 NCT05677971
● Recruiting Phase III Cardiology / Cardiovascular
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
What is being tested: The efficacy of triple therapy (budesonide/glycopyrronium/formoterol – BGF MDI) versus dual therapy (glycopyrronium/formoterol – GFF MDI) in reducing cardiopulmonary outcomes…
13 May 2026 NCT06283966
● Recruiting Phase III Oncology
Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations
What is being tested: Datopotamab deruxtecan (Dato-DXd), a novel antibody-drug conjugate, combined with the PD-L1 inhibitor pembrolizumab versus pembrolizumab monotherapy as first-line treatment for…
13 May 2026 NCT05215340
● Recruiting Phase III
Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency
New oral medication tested in children with growth hormone deficiency to see if it works and identify who benefits most.
12 May 2026 NCT06948214
active not recruiting Phase III Oncology
A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer
T-DXd improves outcomes in HER2-positive advanced breast cancer patients previously treated with anti-HER2 drugs, including those with brain metastases.
12 May 2026 NCT04739761
● Recruiting Phase III
A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
A drug called lebrikizumab was tested for 18 months to see if it helps patients with nasal polyps who already use nasal steroid sprays.
12 May 2026 NCT06338995
● Recruiting Phase III Oncology
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
Treatment being tested: Rilvegostomig (a FGFR4 inhibitor) combined with bevacizumab, evaluated with or without tremelimumab (CTLA-4 inhibitor), compared to the current standard atezolizumab plus…
12 May 2026 NCT06921785
active not recruiting Phase II / Phase III Gastroenterology
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn’s Disease
Guselkumab, a new antibody treatment, shows promise for reducing symptoms and inflammation in moderate-to-severe Crohn's disease.
08 May 2026 NCT03466411
active not recruiting Phase III Cardiology / Cardiovascular
A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation
Milvexian tested against apixaban for preventing stroke and blood clots in atrial fibrillation patients.
08 May 2026 NCT05757869
● Recruiting Phase III
A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment
Pegtibatinase versus placebo for homocystinuria in patients aged 12-65 on standard treatment, measuring safety and effectiveness over 24 weeks.
08 May 2026 NCT06247085
active not recruiting Phase III Rheumatology
A Study to Evaluate the Long-term Safety, Tolerability and Efficacy of Bimekizumab in Subjects With Active Axial Spondyloarthritis Including Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis
Bimekizumab long-term safety and effectiveness study in ankylosing spondylitis and related spine conditions.
08 May 2026 NCT04436640
active not recruiting Phase III Rare Diseases
Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene
Gene therapy injection into the eye shows promise for treating inherited blindness caused by RPGR gene faults in men.
08 May 2026 NCT04794101
active not recruiting Phase II / Phase III Gastroenterology
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
Guselkumab was tested for treating moderate to severe ulcerative colitis, assessing whether it works and is safe.
08 May 2026 NCT04033445
● Recruiting Phase III Oncology
A Long-term Extension Study of PCI-32765 (Ibrutinib)
What is being tested: Long-term safety and efficacy of ibrutinib (PCI-32765), a Bruton's tyrosine kinase (BTK) inhibitor, in patients who have completed primary ibrutinib…
08 May 2026 NCT01804686
● Recruiting Phase III Oncology
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
Treatment being tested: Camizestrant (a selective estrogen receptor degrader) versus standard endocrine therapy in ER+/HER2- early breast cancer patients who have completed at least…
08 May 2026 NCT05774951
● Recruiting Phase III Rheumatology
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
What is being tested: Risankizumab pharmacokinetics (how the drug moves through the body), safety, and efficacy in paediatric patients with ulcerative colitis, extending evidence…
08 May 2026 NCT07071519
● Recruiting Phase III Oncology
A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)
What is being tested: A triple combination therapy of bleximenib plus venetoclax and azacitidine (VEN+AZA) compared to placebo with VEN+AZA alone in newly diagnosed…
08 May 2026 NCT06852222
active not recruiting Phase III Oncology
Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
New drug sacituzumab govitecan compared to standard chemotherapy docetaxel for advanced lung cancer.
07 May 2026 NCT05089734
active not recruiting Phase II / Phase III Oncology
IoN- Is Ablative Radio-iodine Necessary for Low Risk Differentiated Thyroid Cancer Patients
Study testing whether radioactive iodine treatment is needed after surgery for low-risk thyroid cancer patients.
07 May 2026 NCT01398085
● Recruiting Phase III
Study of Oral Deucrictibant XR Tablet for Prophylaxis and Deucrictibant IR Capsule for On-Demand Treatment of Angioedema Attacks in Adults With Acquired Angioedema Due to C1 Inhibitor Deficiency
Trial testing oral deucrictibant tablets to prevent and treat angioedema attacks in adults with C1 inhibitor deficiency.
07 May 2026 NCT07266805
● Recruiting Phase III
Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE
Long-term study showing a daily tablet (deucrictibant) safely prevents angioedema attacks in teenagers and adults with hereditary angioedema.
07 May 2026 NCT06679881
active not recruiting Phase III Oncology
Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)
Enzalutamide plus leuprolide safely improved outcomes in high-risk prostate cancer patients who progressed after surgery or radiotherapy.
07 May 2026 NCT02319837
active not recruiting Phase III Cardiology / Cardiovascular
Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD
Pelacarsen reduced heart attacks and strokes in patients with heart disease and high lipoprotein(a) levels.
06 May 2026 NCT04023552
● Recruiting Phase III Rheumatology
An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants
Anifrolumab (an interferon blocker) tested for safety and effectiveness in children with moderate to severe lupus.
06 May 2026 NCT05835310
active not recruiting Phase III
A Study to Test the Long-term Treatment of Bimekizumab in Study Participants With Moderate to Severe Hidradenitis Suppurativa
Bimekizumab safety study in patients with moderate to severe hidradenitis suppurativa over long-term treatment.
06 May 2026 NCT04901195
● Recruiting Phase III
A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy
What is being tested: Long-term safety and tolerability of iptacopan (LNP023), a complement Factor B inhibitor, in an open-label extension program for patients with…
06 May 2026 NCT04557462
● Recruiting Phase III Oncology
A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator’s Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer
Drug Being Tested: BMS-986365 is being evaluated against standard investigator-selected therapies in a comparative efficacy and safety trial for metastatic castration-resistant prostate cancer (mCRPC).…
06 May 2026 NCT06764485
● Recruiting Phase III Oncology
Neoadjuvant Darovasertib in Primary Uveal Melanoma
What is being tested: Darovasertib, a PKC412 inhibitor, administered before surgery (neoadjuvant approach) in patients with primary uveal melanoma to assess efficacy in reducing…
06 May 2026 NCT07015190
active not recruiting Phase III Infectious Disease
Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F/TAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex With Men and Are At Risk of HIV-1 Infection
Daily F/TAF tablet prevents HIV infection in high-risk men and transgender women compared with F/TDF.
05 May 2026 NCT02842086
active not recruiting Phase III
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
Belzutifan plus lenvatinib compared to cabozantinib for treating advanced kidney cancer after prior treatment.
05 May 2026 NCT04586231
active not recruiting Phase III Oncology
Trial to Evaluate Acasunlimab and Pembrolizumab Combination Superiority Over Standard of Care Docetaxel in Non-Small Cell Lung Cancer (ABBIL1TY NSCLC-06)
New drug combination tested against standard chemotherapy in advanced lung cancer patients who've had prior immunotherapy and chemotherapy.
05 May 2026 NCT06635824
● Recruiting Phase III Oncology
The Study of 177Lu-TLX591 Plus SOC Versus SOC Alone in Patients With mCRPC (ProstACT Global)
What is being tested: 177Lu-TLX591, a targeted radioligand therapy, is being evaluated in combination with standard of care versus standard of care alone in…
05 May 2026 NCT06520345
● Recruiting Phase III Gastroenterology
A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)
What is being tested: Pegozafermin (a FGF21 analogue) at two different dose regimens versus placebo for treating liver fibrosis (stages F2–F3) in adults with…
05 May 2026 NCT06318169
● Recruiting Phase III Respiratory / COPD / Asthma
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn’s Disease (CD)
What is being tested: Vedolizumab, an anti-inflammatory biologic agent targeting gut-specific integrin α4β7, is being evaluated for efficacy and safety in paediatric patients (children…
05 May 2026 NCT04779320
● Recruiting Phase III Cardiology / Cardiovascular
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
What is being tested: Omecamtiv mecarbil (CK-1827452), an investigational cardiac myosin activator, is being evaluated to determine if it reduces adverse outcomes including hospitalisation,…
05 May 2026 NCT06736574
● Recruiting Phase III Oncology
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
What is being tested: ALLTogether is a master protocol that consolidates evidence-based treatment approaches for acute lymphoblastic leukaemia (ALL) across infants, children, and young…
05 May 2026 NCT04307576
active not recruiting Phase III
A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA)
Monthly eye injections of vonaprument tested to slow vision loss in dry age-related macular degeneration with geographic atrophy.
04 May 2026 NCT06510816
● Recruiting Phase III Gastroenterology
A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis
A new drug called Afimkibart is being tested to see if it safely treats moderate to severe ulcerative colitis better than placebo.
04 May 2026 NCT06588855
active not recruiting Phase III
A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56
Two-year trial testing EYP-1901 against aflibercept for wet age-related macular degeneration, with main results at one year.
04 May 2026 NCT06683742
● Recruiting Phase III Gastroenterology
A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn’s Disease
New drug afimkibart tested for safely treating moderate-to-severe Crohn's disease in a phase three trial comparing it against placebo.
04 May 2026 NCT06819878