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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

2231 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

2231 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

active not recruiting Phase III
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors
Crovalimab was as safe and effective as eculizumab in treating PNH patients already on complement inhibitor therapy.
26 Oct 2026 NCT04432584
● Recruiting Phase III Rheumatology
An Open-label Study to Evaluate the Pharmacokinetics and Safety of Bimekizumab in Pediatric Study Participants With Active Juvenile Idiopathic Arthritis Subtypes Enthesitis-related Arthritis (Including Juvenile-onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis
Study tested bimekizumab drug levels and safety in children with inflammatory arthritis conditions.
23 Oct 2026 NCT06668181
● Recruiting Phase III Cardiology / Cardiovascular
A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)
What is being tested: MK-8748, a novel investigational therapy, is being compared against aflibercept (standard treatment) to evaluate its efficacy and safety in treating…
23 Oct 2026 NCT07705555
● Recruiting Phase III Oncology
A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions
What is being tested: Elritercept, a novel therapeutic agent, is being evaluated for its efficacy in reducing red blood cell (RBC) transfusion requirements in…
23 Oct 2026 NCT06499285
active not recruiting Phase III Oncology
A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015)
A new cancer drug (sacituzumab tirumotecan) is being tested against standard treatment in advanced stomach cancer to see if it improves survival.
22 Oct 2026 NCT06356311
active not recruiting Phase III Cardiology / Cardiovascular
Study of ALXN2220 Versus Placebo in Adults With ATTR-CM
ALXN2220 drug tested against placebo in adults with heart amyloidosis, measuring death and heart-related events.
22 Oct 2026 NCT06183931
● Recruiting Phase III Cardiology / Cardiovascular
Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease
What is being tested: Two novel Factor XI inhibitors (REGN7508 and REGN9933) are being evaluated to reduce adverse vascular events in patients with Peripheral…
22 Oct 2026 NCT07318610
● Recruiting Phase III Cardiology / Cardiovascular
A Phase III, Multicentre Study to Evaluate Consolidation Treatment With AZD0120 Compared With ASCT, in Participants With Newly Diagnosed Multiple Myeloma Who Are Transplant Eligible (DURGA-6).
Treatment Being Tested: AZD0120 (a novel consolidation therapy) is being compared against autologous stem cell transplantation (ASCT) as consolidation treatment in newly diagnosed multiple…
22 Oct 2026 NCT07735637
active not recruiting Phase III
Study to Learn If Tofersen (BIIB067) Can Delay ALS Symptoms and About Its Safety in Adults With a SOD1 Gene Mutation Who Have Not Yet Developed ALS Symptoms
Trial testing whether tofersen can delay symptom onset in adults with SOD1 gene mutation before ALS develops.
20 Oct 2026 NCT04856982
active not recruiting Phase III Oncology
A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)
Belzutifan compared to everolimus for advanced kidney cancer, testing if belzutifan improves survival and delays disease progression.
20 Oct 2026 NCT04195750
● Recruiting Phase III
A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Riliprubart compared to standard IVIg treatment in adults with CIDP over 109 weeks.
19 Oct 2026 NCT06290141
active not recruiting Phase III Cardiology / Cardiovascular
A Study of Rusfertide in Adults With Polycythemia Vera (PV)
Rusfertide reduced the need for blood removal in polycythemia vera patients by limiting iron availability for red blood cell production.
19 Oct 2026 NCT05210790
● Recruiting Phase III Infectious Disease
An Open Label Clinical Study to Evaluate Tanruprubart (Also Commonly Known as ANX005) in Participants With Guillain-Barré Syndrome (FORWARD Study)
The goal of this open label study is to measure pharmacokinetics, pharmacodynamics, early efficacy, and safety of tanruprubart in adult and pediatric participants, in…
19 Oct 2026 NCT07020819
● Recruiting Phase III Diabetes / Metabolic
A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes
This study looks at how well a medicine called orforglipron works compared to another medicine called dulaglutide in pediatric participants aged 10 to less…
19 Oct 2026 NCT07668336
● Recruiting Phase III Rheumatology
A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
This is a multicenter, randomized, double-blind, placebo-controlled Phase 3 maintenance study to evaluate the efficacy and safety of duvakitug in participants with moderately to…
16 Oct 2026 NCT07185009
active not recruiting Phase III
A Study to Investigate Efficacy, Safety, and Tolerability of Remibrutinib Compared With Placebo in Adults With CINDU Inadequately Controlled by H1-antihistamines
Remibrutinib reduces itch and hives in chronic urticaria patients not controlled by antihistamines over 52 weeks.
15 Oct 2026 NCT05976243
● Recruiting Phase III
A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear Palsy
NIO752 is being tested to see if it can help slow progression of Progressive Supranuclear Palsy, a rare brain disorder affecting movement and balance.
15 Oct 2026 NCT07498426
active not recruiting Phase III Oncology
A Study of Sasanlimab in People With Non-muscle Invasive Bladder Cancer
Trial testing sasanlimab combined with BCG treatment for early-stage bladder cancer to assess safety and effectiveness.
15 Oct 2026 NCT04165317
● Recruiting Phase III Oncology
Saruparib in Combination With Physician’s Choice of ARPI in Patients With mHSPC Previously Treated With Docetaxel or 177Lu-PSMA Therapy Without Disease Progression and PSA ≥ 0.2 ng/mL (EvoPAR-PR05)
The primary objective of this study is to measure efficacy of saruparib + physician's choice of ARPI compared with placebo + ARPI in men…
15 Oct 2026 NCT07711002
● Recruiting Phase III Rare Diseases
A Gaucher Disease Gene Therapy Trial With FLT201
Gene therapy FLT201 tested in Gaucher disease patients already on standard treatment, assessing whether it allows safe discontinuation of current medications.
14 Oct 2026 NCT07223944
active not recruiting Phase III Oncology
A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer
ALK-positive lung cancer patients randomly received either alectinib tablets for two years or chemotherapy for four months; alectinib improved recurrence-free survival.
14 Oct 2026 NCT03456076
active not recruiting Phase III Oncology
A Study of Dato-DXd With or Without Durvalumab Versus Investigator’s Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)
TROPION-Breast03 Summary New cancer drug Dato-DXd, with or without immunotherapy, tested against standard treatment in triple-negative breast cancer patients with remaining disease after chemotherapy.
14 Oct 2026 NCT05629585
● Recruiting Phase III Rheumatology
A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn’s Disease
The purpose of this study is to assess how well JNJ-78934804 works (efficacy) and how safe it is (safety) as compared to guselkumab at…
14 Oct 2026 NCT07577843
● Recruiting Phase III
Lisaftoclax (APG-2575) Combined With Azacytidine (AZA) in the Treatment of Patients With Higher-risk Myelodysplastic Syndrome (GLORA-4).
GLORA-4 Trial Summary Adding lisaftoclax to azacitidine improves survival in newly diagnosed high-risk myelodysplastic syndrome compared to azacitidine alone.
13 Oct 2026 NCT06641414
● Recruiting Phase II / Phase III Gastroenterology
A Clinical Study to Assess Safety, Efficacy and Pharmacodynamic Profile of GNT0004 in Duchenne Muscular Dystrophy
GNT0004 is a one-time gene therapy delivering a functional dystrophin gene to slow Duchenne muscular dystrophy progression.
13 Oct 2026 NCT07856329
● Recruiting Phase III Cardiology / Cardiovascular
Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma
The purpose of this study is to assess the efficacy and safety of cevostamab in combination with pomalidomide and dexamethasone (CevosPd) versus standard of…
13 Oct 2026 NCT07555938
active not recruiting Phase III
A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy
Long-term study showing VX-121 combination therapy is safe and effective for treating cystic fibrosis patients.
09 Oct 2026 NCT05444257
● Recruiting Phase III Oncology
Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)
Treatment being tested: Gedatolisib (a PI3K/mTOR inhibitor) combined with palbociclib (CDK4/6 inhibitor) and endocrine therapy, compared to standard palbociclib plus endocrine therapy in first-line…
09 Oct 2026 NCT06757634
● Recruiting Phase III Oncology
A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)
What is being tested: The combination of calderasib (MK-1084), a KRAS G12C inhibitor, with durvalumab (an immunotherapy) in patients with locally advanced, unresected non-small…
09 Oct 2026 NCT07554339
● Recruiting Phase III Gastroenterology
A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
Trial testing linvoseltamab alone or with carfilzomib versus standard treatments in patients with relapsed/refractory myeloma after 1-3 prior therapies.
08 Oct 2026 NCT07222761
● Recruiting Phase III
Pridopidine Phase 3 Study in Huntington’s Disease
Pridopidine versus placebo over one year to assess whether the drug slows Huntington's Disease progression and worsens symptoms.
07 Oct 2026 NCT07609108
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM)
Treatment being tested: Linvoseltamab (an experimental bispecific antibody) is being compared to daratumumab (an established monoclonal antibody) in patients with high-risk smoldering multiple myeloma…
07 Oct 2026 NCT07393282
active not recruiting Phase II / Phase III
Setrusumab vs Placebo for Osteogenesis Imperfecta
Setrusumab (an antibody) reduces fractures in osteogenesis imperfecta patients compared to placebo.
06 Oct 2026 NCT05125809
active not recruiting Phase III Cardiology / Cardiovascular
Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events
Inclisiran added to statins slows coronary artery plaque buildup in patients with mild coronary disease, measured by CT scans over two years.
05 Oct 2026 NCT05360446
● Recruiting Phase III Diabetes / Metabolic
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)
What is being tested: Long-term efficacy, safety, and tolerability of maridebart cafraglutide, a novel dual-action GLP-1/GIP receptor agonist, in patients with concurrent obesity and…
05 Oct 2026 NCT07684144
● Recruiting Phase III Oncology
Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
What is being tested: Atebimetinib (a MEK inhibitor) combined with modified gemcitabine-nab-paclitaxel (GnP) chemotherapy versus standard-of-care GnP alone as first-line treatment for metastatic pancreatic…
05 Oct 2026 NCT07562152
● Recruiting Phase III Oncology
INTREPID: A Study of Sapablursen Evaluating the Safety and Efficacy in Participants With Polycythemia Vera (PV)
What is being tested: Sapablursen, an investigational antisense oligonucleotide, is being evaluated as an add-on therapy to standard of care treatment in patients with…
05 Oct 2026 NCT07429266
active not recruiting Phase III
A Phase III Study Evaluating Glofitamab in Combination With Gemcitabine + Oxaliplatin vs Rituximab in Combination With Gemcitabine + Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Glofitamab plus chemotherapy compared to rituximab plus chemotherapy for treating relapsed or refractory diffuse large B-cell lymphoma.
02 Oct 2026 NCT04408638
● Recruiting Phase III Rare Diseases
CAR-T Long Term Follow Up (LTFU) Study
Study tracking safety and effectiveness of CAR-T cancer therapy in patients for 15 years after treatment to detect delayed problems.
02 Oct 2026 NCT02445222
● Recruiting Phase III Oncology
A Study to Investigate Mocertatug Rezetecan Compared With Standard of Care in Participants With Platinum-resistant Ovarian Cancer (BEHOLD-Ovarian01)
What is being tested: Mocertatug rezetecan (Mo-Rez), a novel targeted therapy, is being compared against standard-of-care treatment in patients with platinum-resistant ovarian cancer, with…
02 Oct 2026 NCT07286266
● Recruiting Phase III Gastroenterology
A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangitis
Elafibranor versus placebo for primary sclerosing cholangitis: a trial assessing efficacy and safety in 350 adults over five years.
01 Oct 2026 NCT07387549
active not recruiting Phase III Neurology
Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis
IMU-838 reduced relapses in relapsing multiple sclerosis compared to placebo in this large randomised trial.
01 Oct 2026 NCT05201638
active not recruiting Phase II / Phase III
A Study to Evaluate the Efficacy and Safety of 2 Doses of EYE103 Compared With Ranibizumab (0.5 mg) in Participants With DME
EYE103 compared with ranibizumab for diabetic macular swelling, initially monthly then personalised treatment intervals.
30 Sep 2026 NCT06571045
active not recruiting Phase III Oncology
Stereotactic Ablative Radiotherapy for Comprehensive Treatment of 4-10 Oligometastatic Tumors
SABR versus standard care for patients with 4-10 cancer spread sites: testing survival and quality-of-life benefits.
30 Sep 2026 NCT03721341
● Recruiting Phase III Oncology
A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma
Treatment being tested: Linvoseltamab (REGN5458), a novel experimental bispecific antibody, is being directly compared against the established combination therapy of elotuzumab, pomalidomide, and dexamethasone…
30 Sep 2026 NCT05730036
active not recruiting Phase III Oncology
A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer
Trial testing whether tucatinib improves survival in advanced HER2-positive breast cancer when combined with standard drugs trastuzumab and pertuzumab.
29 Sep 2026 NCT05132582
active not recruiting Phase III
Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC
Adding talazoparib to enzalutamide delays cancer progression longer than enzalutamide alone in men with advanced prostate cancer.
29 Sep 2026 NCT03395197
active not recruiting Phase III Oncology
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy
Atezolizumab immunotherapy versus placebo after bladder removal surgery in patients with high-risk cancer and detectable tumour DNA.
28 Sep 2026 NCT04660344
active not recruiting Phase III Oncology
A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure
Adding amivantamab and lazertinib to chemotherapy improves outcomes in EGFR-mutated lung cancer patients who've failed osimertinib.
28 Sep 2026 NCT04988295
● Recruiting Phase III Diabetes / Metabolic
Anti-vascular Endothelial Growth Factor (Anti-VEGF) Monotherapy vs Anti-VEGF Followed by Subthreshold Micropulse Laser for Treating Severe Diabetic Macular Oedema When the Central Retina Goes <400 Microns
Anti-VEGF injections alone versus anti-VEGF followed by laser treatment for severe diabetic eye swelling when swelling reduces.
28 Sep 2026 NCT06985706