- A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05) — Active Not Recruiting • Phase III • Oncology • NCT04622319.
- T-DXd compared to T-DM1 for HER2-positive breast cancer with residual disease after chemotherapy.
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Patients with HER2-positive primary breast cancer (BC) who do not achieve complete response after appropriate neoadjuvant therapy are at higher risk of disease recurrence. More effective treatment options are needed for this patient population. This study will examine the efficacy and safety of trastuzumab deruxtecan (T-DXd) compared with trastuzumab emtansine (T-DM1) in high-risk patients with residual invasive breast cancer following neoadjuvant therapy. Conditions: HER2-Positive Primary Breast Cancer, Residual Invasive Breast Cancer Interventions: DS-8201a, T-DM1 Lead Sponsor: Daiichi Sankyo Planned Enrollment: 1635 participants