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Trial Radar

2236 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

2236 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

● Recruiting Phase III Cardiology / Cardiovascular
A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide
What is being tested: Two novel bispecific antibody combinations (talquetamab plus pomalidomide, and talquetamab plus teclistamab) are being compared against standard treatment regimens (EPd…
03 Jun 2026 NCT06208150
● Recruiting Phase III Oncology
A Study to Evaluate Glofitamab as a Single Agent vs. Investigator’s Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma
What is being tested: Glofitamab monotherapy (a CD20/CD3 bispecific antibody) is being compared against standard salvage regimens (rituximab-bendamustine or rituximab-lenalidomide) in patients with relapsed…
03 Jun 2026 NCT06084936
active not recruiting Phase III Gastroenterology
A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES)
A drug called resmetirom tested to see if it prevents liver disease progression in patients with advanced fatty liver cirrhosis.
02 Jun 2026 NCT05500222
● Recruiting Phase III
A Study to Learn More About the Effects and Long-Term Safety of Omaveloxolone (BIIB141) in Children and Teens With Friedreich’s Ataxia
Study testing omaveloxolone safety and effectiveness in children aged 2-15 with Friedreich's ataxia over three years.
02 Jun 2026 NCT06953583
active not recruiting Phase III Oncology
A Study of DB-1303/BNT323 vs Investigator’s Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)
DB-1303/BNT323 versus standard chemotherapy for HER2-low, hormone receptor positive advanced breast cancer, measuring time to disease progression.
02 Jun 2026 NCT06018337
● Recruiting Phase III Oncology
A Study of Ifinatamab Deruxtecan Versus Treatment of Physician’s Choice in Subjects With Relapsed Small Cell Lung Cancer
What is being tested: Ifinatamab deruxtecan (I-DXd), a novel antibody-drug conjugate targeting DLL3, is being compared against standard physician-selected chemotherapy in patients with relapsed…
02 Jun 2026 NCT06203210
● Recruiting Phase III Oncology
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma
What is being tested: A triple combination therapy consisting of subcutaneous epcoritamab (bispecific antibody), intravenous rituximab (monoclonal antibody), and oral lenalidomide (immunomodulatory agent) in…
02 Jun 2026 NCT06191744
active not recruiting Phase III
A Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With Spinal Muscular Atrophy
Trial testing a new add-on treatment (taldefgrobep alfa) alongside existing spinal muscular atrophy medicines to see if it helps and is safe.
01 Jun 2026 NCT05337553
active not recruiting Phase III Oncology
A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.
Adding tazemetostat to lenalidomide and rituximab improves progression-free survival in relapsed/refractory follicular lymphoma compared to placebo.
01 Jun 2026 NCT04224493
● Recruiting Phase III Oncology
Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
Treatment being tested: BNT327 (pumitamig), a novel investigational therapy, combined with standard chemotherapy (etoposide/carboplatin) versus the current standard of care atezolizumab plus chemotherapy in…
01 Jun 2026 NCT06712355
● Recruiting Phase III Oncology
A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis
Treatment being tested: Remibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, is being evaluated as an add-on therapy to standard-of-care treatment in generalised myasthenia gravis…
01 Jun 2026 NCT06744920
active not recruiting Phase III Dermatology
Study to Assess the Long-term Safety of Dupilumab Administered in Participants ≥6 Months to <18 Years of Age With Atopic Dermatitis (AD)
Long-term safety and effectiveness study of dupilumab injection in children aged six months to eighteen years with atopic dermatitis.
29 May 2026 NCT02612454
active not recruiting Phase III Neurology
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)
Remibrutinib and teriflunomide showed similar effectiveness and safety for treating relapsing multiple sclerosis.
29 May 2026 NCT05156281
active not recruiting Phase III Neurology
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)
Remibrutinib was tested against teriflunomide in relapsing MS patients to compare how well each drug works and its safety profile.
29 May 2026 NCT05147220
● Recruiting Phase III Respiratory / COPD / Asthma
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
What is being tested: Daraxonrasib (RMC-6236), a novel RAS(ON) inhibitor, is being evaluated against docetaxel chemotherapy for safety and efficacy in patients with RAS-mutated…
29 May 2026 NCT06881784
● Recruiting Phase III Cardiology / Cardiovascular
Phase 3 Clinical Study Evaluating Efficacy, Safety, and Tolerability of Obicetrapib Vs Bempedoic Acid to Treat Dyslipidemia in Adults With Primary Non-familial Hypercholesterolemia or Mixed Dyslipidemia at High to Very High Cardiovascular Risk, During a Treatment Period of Approximately 84 Days
What is being tested: Obicetrapib (OBI), a novel CETP inhibitor, is being directly compared to bempedoic acid (BPA) for reducing LDL-cholesterol in adults with…
29 May 2026 NCT07614958
● Recruiting Phase III Cardiology / Cardiovascular
A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD
What is being tested: L606 is being evaluated in a Phase 3 trial to assess its safety and efficacy in treating pulmonary hypertension secondary…
29 May 2026 NCT07285655
active not recruiting Phase III
Phase 3 Study of ALXN1850 in Treatment-Naïve Pediatric Participants With HPP
A new drug (ALXN1850) was tested against placebo in children with bone disease to see if it improves bone health.
28 May 2026 NCT06079359
● Recruiting Phase III
A Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP
A new drug (empasiprubart) is being tested to see if it safely improves symptoms in adults with chronic nerve inflammation (CIDP).
28 May 2026 NCT07091630
● Recruiting Phase III Diabetes / Metabolic
A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs
A new drug (Debio 4126) tested against placebo to control growth hormone levels in acromegaly patients previously treated with somatostatin analogs.
28 May 2026 NCT06930625
● Recruiting Phase III Oncology
AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)
What is being tested: AZD2265, a novel therapeutic agent, is being evaluated against standard-of-care treatments in patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC),…
28 May 2026 NCT07611110
● Recruiting Phase III Oncology
An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
What is being tested: Camizestrant (AZD9833), a selective oestrogen receptor degrader (SERD), is being compared to standard adjuvant endocrine therapy (aromatase inhibitors or tamoxifen)…
28 May 2026 NCT05952557
● Recruiting Phase III Oncology
A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials
What is being tested: Long-term safety profile of luspatercept (ACE-536) in patients transitioning from completed or concluded parent clinical trials, using an open-label rollover…
28 May 2026 NCT04064060
● Recruiting Phase III Oncology
A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer
What is being tested: Zolbetuximab (a monoclonal antibody targeting claudin-18.2) combined with pembrolizumab (PD-1 inhibitor) and chemotherapy as a treatment for advanced gastric and…
28 May 2026 NCT06901531
active not recruiting Phase III Oncology
Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)
DESTINY-Gastric04 Summary Trastuzumab deruxtecan improves survival compared with ramucirumab plus paclitaxel in HER2-positive gastric cancer after trastuzumab treatment.
27 May 2026 NCT04704934
active not recruiting Phase III Rheumatology
A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Study Participants With Active Psoriatic Arthritis
Bimekizumab compared to risankizumab for treating active psoriatic arthritis over 16 weeks.
27 May 2026 NCT06624228
● Recruiting Phase III
A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington’s Disease
A trial testing whether votoplam slows Huntington's disease progression in early symptomatic patients compared with placebo.
27 May 2026 NCT07326709
● Recruiting Phase III
A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)
A trial testing whether nipocalimab injection safely prevents severe low platelet counts in babies of at-risk pregnant women.
27 May 2026 NCT06533098
active not recruiting Phase III
Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta
Romosozumab versus bisphosphonates for reducing fractures and improving bone density in children with osteogenesis imperfecta over 12 months.
27 May 2026 NCT05972551
● Recruiting Phase III Oncology
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn’s Disease
What is being tested: The efficacy of dual targeted therapy combining vedolizumab (α4β7 integrin inhibitor) and upadacitinib (JAK inhibitor) versus vedolizumab monotherapy in reducing…
27 May 2026 NCT06227910
● Recruiting Phase III Oncology
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
Treatment being tested: A fixed-duration combination of sonrotoclax (a novel BCL2 inhibitor) plus zanubrutinib (a Bruton tyrosine kinase inhibitor) compared to the established venetoclax…
27 May 2026 NCT07277231
active not recruiting Phase III Oncology
Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)
Testing whether adding pembrolizumab and olaparib to chemotherapy and radiation improves survival in early-stage small cell lung cancer.
26 May 2026 NCT04624204
active not recruiting Phase III Oncology
Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
GLORIOSA Trial Summary Adding mirvetuximab soravtansine to bevacizumab improves outcomes in platinum-sensitive ovarian cancer with high folate receptor expression.
26 May 2026 NCT05445778
● Recruiting Phase III Oncology
Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)
Treatment being tested: Trastuzumab deruxtecan (T-DXd), a HER2-targeted antibody-drug conjugate, combined with bevacizumab versus bevacizumab alone as first-line maintenance therapy in patients with HER2-expressing…
26 May 2026 NCT06819007
● Recruiting Phase III Oncology
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
What is being tested: Dostarlimab (a PD-1 checkpoint inhibitor) versus placebo as maintenance therapy following chemoradiation in patients with locally advanced, unresectable head and…
26 May 2026 NCT06256588
active not recruiting Phase III
A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) in Non-Ambulatory and Ambulatory Participants With Duchenne Muscular Dystrophy (DMD)
A gene therapy trial testing whether a single infusion can slow muscle weakness in boys with Duchenne muscular dystrophy.
22 May 2026 NCT05881408
active not recruiting Phase III Oncology
(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors
Adding CGT9486 to sunitinib compared to sunitinib alone for gastrointestinal stromal tumour patients who've failed or are intolerant to imatinib.
22 May 2026 NCT05208047
active not recruiting Phase III Diabetes / Metabolic
A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ – CVOT)
Survodutide injection reduces cardiovascular events in overweight or obese adults with heart or kidney disease compared to placebo.
22 May 2026 NCT06077864
● Recruiting Phase III Oncology
A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
What is being tested: Tabelecleucel, an EBV-specific T-cell immunotherapy, is being evaluated for treating EBV-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in solid organ and…
22 May 2026 NCT03394365
● Recruiting Phase III Oncology
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator’s Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
Treatment being tested: Golcadomide combined with rituximab (Golca + R) versus investigator's choice treatment in patients with relapsed/refractory follicular lymphoma, evaluated in a Phase…
20 May 2026 NCT06911502
● Recruiting Phase III Oncology
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator’s Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
What is being tested: Golcadomide combined with rituximab (Golca + R) versus standard investigator-selected treatment in patients with relapsed/refractory follicular lymphoma, evaluating efficacy and…
20 May 2026 NCT06911502
● Recruiting Phase III Oncology
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
What is being tested: Puxitatug samrotecan (AZD8205), a B7-H4-targeted therapy, versus standard chemotherapy (doxorubicin or paclitaxel) in patients with advanced/metastatic endometrial cancer that has…
20 May 2026 NCT07044336
● Recruiting Phase III Oncology
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
Treatment being tested: Puxitatug samrotecan (AZD8205), a novel B7-H4-directed antibody-drug conjugate, compared against standard chemotherapy (doxorubicin or paclitaxel) in a Phase III randomized trial…
20 May 2026 NCT07044336
● Recruiting Phase III Oncology
A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients
Treatment being tested: Surovatamig (AZD0486), a novel agent, combined with rituximab versus standard immunochemotherapy regimens (investigator's choice of three options) in previously untreated follicular…
20 May 2026 NCT06549595
● Recruiting Phase III Oncology
A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients
What is being tested: Surovatamig (AZD0486), a novel agent, combined with rituximab versus standard immunochemotherapy regimens (investigator's choice of 3 options) in treatment-naive follicular…
20 May 2026 NCT06549595
active not recruiting Phase III
Study of Oral Atogepant Tablets to Assess Safety and Efficacy in Adult Participants With Migraine
Atogepant tablets tested for treating individual migraine attacks in adults; currently approved only for prevention.
19 May 2026 NCT06241313
● Recruiting Phase III Diabetes / Metabolic
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
Tirzepatide with lifestyle changes reduced weight and improved heart disease risk factors in obese teenagers with related health problems.
19 May 2026 NCT06439277
● Recruiting Phase III
A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
Trial testing atogepant tablets versus placebo for preventing chronic migraine in teenagers aged 12-17 years over 12 weeks.
19 May 2026 NCT06810505
● Recruiting Phase III Diabetes / Metabolic
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
AMAZE 12 Summary Trial testing whether weekly injections of NNC0487-0111 help people maintain weight loss compared to placebo.
19 May 2026 NCT07503210
active not recruiting Phase III Cardiology / Cardiovascular
Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)
Long-term safety and effectiveness study of inhaled seralutinib for pulmonary hypertension patients who previously completed earlier trials.
19 May 2026 NCT06274801