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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

1963 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

1963 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

● Recruiting Phase III Oncology
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn’s Disease
What is being tested: The efficacy of dual targeted therapy combining vedolizumab (α4β7 integrin inhibitor) and upadacitinib (JAK inhibitor) versus vedolizumab monotherapy in reducing…
27 May 2026 NCT06227910
● Recruiting Phase III Oncology
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
Treatment being tested: A fixed-duration combination of sonrotoclax (a novel BCL2 inhibitor) plus zanubrutinib (a Bruton tyrosine kinase inhibitor) compared to the established venetoclax…
27 May 2026 NCT07277231
active not recruiting Phase III Oncology
Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)
Testing whether adding pembrolizumab and olaparib to chemotherapy and radiation improves survival in early-stage small cell lung cancer.
26 May 2026 NCT04624204
active not recruiting Phase III Oncology
Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
GLORIOSA Trial Summary Adding mirvetuximab soravtansine to bevacizumab improves outcomes in platinum-sensitive ovarian cancer with high folate receptor expression.
26 May 2026 NCT05445778
● Recruiting Phase III Oncology
Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)
Treatment being tested: Trastuzumab deruxtecan (T-DXd), a HER2-targeted antibody-drug conjugate, combined with bevacizumab versus bevacizumab alone as first-line maintenance therapy in patients with HER2-expressing…
26 May 2026 NCT06819007
● Recruiting Phase III Oncology
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
What is being tested: Dostarlimab (a PD-1 checkpoint inhibitor) versus placebo as maintenance therapy following chemoradiation in patients with locally advanced, unresectable head and…
26 May 2026 NCT06256588
active not recruiting Phase III
A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) in Non-Ambulatory and Ambulatory Participants With Duchenne Muscular Dystrophy (DMD)
A gene therapy trial testing whether a single infusion can slow muscle weakness in boys with Duchenne muscular dystrophy.
22 May 2026 NCT05881408
active not recruiting Phase III Oncology
(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors
Adding CGT9486 to sunitinib compared to sunitinib alone for gastrointestinal stromal tumour patients who've failed or are intolerant to imatinib.
22 May 2026 NCT05208047
active not recruiting Phase III Diabetes / Metabolic
A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ – CVOT)
Survodutide injection reduces cardiovascular events in overweight or obese adults with heart or kidney disease compared to placebo.
22 May 2026 NCT06077864
● Recruiting Phase III Oncology
A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
What is being tested: Tabelecleucel, an EBV-specific T-cell immunotherapy, is being evaluated for treating EBV-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in solid organ and…
22 May 2026 NCT03394365
● Recruiting Phase III Oncology
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator’s Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
Treatment being tested: Golcadomide combined with rituximab (Golca + R) versus investigator's choice treatment in patients with relapsed/refractory follicular lymphoma, evaluated in a Phase…
20 May 2026 NCT06911502
● Recruiting Phase III Oncology
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator’s Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
What is being tested: Golcadomide combined with rituximab (Golca + R) versus standard investigator-selected treatment in patients with relapsed/refractory follicular lymphoma, evaluating efficacy and…
20 May 2026 NCT06911502
● Recruiting Phase III Oncology
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
What is being tested: Puxitatug samrotecan (AZD8205), a B7-H4-targeted therapy, versus standard chemotherapy (doxorubicin or paclitaxel) in patients with advanced/metastatic endometrial cancer that has…
20 May 2026 NCT07044336
● Recruiting Phase III Oncology
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
Treatment being tested: Puxitatug samrotecan (AZD8205), a novel B7-H4-directed antibody-drug conjugate, compared against standard chemotherapy (doxorubicin or paclitaxel) in a Phase III randomized trial…
20 May 2026 NCT07044336
● Recruiting Phase III Oncology
A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients
Treatment being tested: Surovatamig (AZD0486), a novel agent, combined with rituximab versus standard immunochemotherapy regimens (investigator's choice of three options) in previously untreated follicular…
20 May 2026 NCT06549595
● Recruiting Phase III Oncology
A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients
What is being tested: Surovatamig (AZD0486), a novel agent, combined with rituximab versus standard immunochemotherapy regimens (investigator's choice of 3 options) in treatment-naive follicular…
20 May 2026 NCT06549595
active not recruiting Phase III
Study of Oral Atogepant Tablets to Assess Safety and Efficacy in Adult Participants With Migraine
Atogepant tablets tested for treating individual migraine attacks in adults; currently approved only for prevention.
19 May 2026 NCT06241313
● Recruiting Phase III Diabetes / Metabolic
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
Tirzepatide with lifestyle changes reduced weight and improved heart disease risk factors in obese teenagers with related health problems.
19 May 2026 NCT06439277
● Recruiting Phase III
A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
Trial testing atogepant tablets versus placebo for preventing chronic migraine in teenagers aged 12-17 years over 12 weeks.
19 May 2026 NCT06810505
● Recruiting Phase III Diabetes / Metabolic
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
AMAZE 12 Summary Trial testing whether weekly injections of NNC0487-0111 help people maintain weight loss compared to placebo.
19 May 2026 NCT07503210
active not recruiting Phase III Cardiology / Cardiovascular
Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)
Long-term safety and effectiveness study of inhaled seralutinib for pulmonary hypertension patients who previously completed earlier trials.
19 May 2026 NCT06274801
active not recruiting Phase III Oncology
A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies
Trial testing whether adding darolutamide to hormone therapy improves survival in men with early prostate cancer recurrence after surgery or radiotherapy.
19 May 2026 NCT05794906
active not recruiting Phase III Oncology
A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)
persevERA Trial Summary A new breast cancer drug (giredestrant) plus palbociclib compared to standard treatment (letrozole) plus palbociclib in advanced hormone-receptor-positive breast cancer.
19 May 2026 NCT04546009
● Recruiting Phase III Rheumatology
Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn’s Disease or Ulcerative Colitis (MK-7240-011)
What is being tested: Long-term safety and efficacy of tulisokibart (MK-7240), a novel therapeutic agent designed to treat active, moderate to severe Crohn's disease…
19 May 2026 NCT06651281
● Recruiting Phase III Respiratory / COPD / Asthma
A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza
What is being tested: CD388 is a novel therapeutic agent administered as a single dose via 3 subcutaneous injections, being evaluated for its efficacy…
19 May 2026 NCT07159763
● Recruiting Phase III Oncology
A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma
What is being tested: Odronextamab, a novel bispecific antibody, is being evaluated for safety, tolerability, and efficacy compared to rituximab combined with chemotherapy in…
19 May 2026 NCT06091254
● Recruiting Phase III
A Study to Assess the Efficacy and Safety of Emicizumab in Participants With Type 3 Von Willebrand Disease
Emicizumab prophylaxis reduces bleeding events in Type 3 von Willebrand disease compared to standard on-demand treatment.
18 May 2026 NCT06998524
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy
What is being tested: Sotagliflozin (a dual SGLT1/SGLT2 inhibitor) efficacy and safety in reducing symptoms and functional limitations in patients with symptomatic hypertrophic cardiomyopathy,…
18 May 2026 NCT06481891
● Recruiting Phase III Oncology
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).
Treatment being tested: Nemtabrutinib (a Bruton's tyrosine kinase inhibitor) combined with venetoclax compared to the standard regimen of venetoclax plus rituximab in patients with…
18 May 2026 NCT05947851
active not recruiting Phase III
Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)
Povetacicept reduced proteinuria and slowed kidney decline in adults with IgA nephropathy compared to placebo.
15 May 2026 NCT06564142
● Recruiting Phase III
Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).
TIGER Trial Summary Surgery plus anti-VEGF injections versus anti-VEGF alone for bleeding under the macula in wet age-related macular degeneration.
15 May 2026 NCT04663750
● Recruiting Phase III
An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemia
Trial testing sodium zirconium cyclosilicate to treat high potassium levels in children aged under 18 years across correction, maintenance and long-term phases.
15 May 2026 NCT03813407
active not recruiting Phase III
HAELO: A Phase 3 Study to Evaluate NTLA-2002 in Participants With Hereditary Angioedema (HAE)
Gene therapy NTLA-2002 reduced hereditary angioedema attacks more effectively than placebo in a Phase 3 trial.
15 May 2026 NCT06634420
active not recruiting Phase III
Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)
ZENITH High Proteinuria Trial Summary Adding zibotentan to dapagliflozin versus dapagliflozin alone for reducing protein loss in chronic kidney disease patients.
15 May 2026 NCT06087835
● Recruiting Phase III Cardiology / Cardiovascular
Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
What is being tested: Inclisiran, a small interfering RNA (siRNA) therapeutic that lowers LDL cholesterol by inhibiting PCSK9 production, is being evaluated for safety,…
15 May 2026 NCT06597019
● Recruiting Phase III Oncology
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
What is being tested: Ifinatamab deruxtecan (I-DXd/MK-2400), a novel targeted therapy designed to treat metastatic castration-resistant prostate cancer (mCRPC), with the primary objective of…
15 May 2026 NCT06925737
active not recruiting Phase III
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Thyroid Eye Disease
Satralizumab injection tested for treating thyroid eye disease by blocking inflammation.
14 May 2026 NCT06106828
● Recruiting Phase III
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
Trial testing whether brenipatide reduces alcohol use better than placebo in people with moderate-to-severe alcohol use disorder over 56 weeks.
14 May 2026 NCT07219966
active not recruiting Phase III Oncology
DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)
Tovorafenib compared to standard chemotherapy for treating children with low-grade brain tumours with RAF mutations.
14 May 2026 NCT05566795
● Recruiting Phase III Oncology
A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
What is being tested: Dato-DXd (a novel antibody-drug conjugate) as monotherapy or combined with osimertinib versus standard platinum-based chemotherapy, with primary endpoint of progression-free…
14 May 2026 NCT06417814
● Recruiting Phase III Oncology
A Study to Evaluate the Benefit of Adding Durvalumab After Chemotherapy, Durvalumab and Surgery in Patients With Early-stage, Operable, Non-small Cell Lung Cancer.
What is being tested: The addition of adjuvant (post-operative) durvalumab (PD-L1 inhibitor) versus observation alone, following neoadjuvant durvalumab plus chemotherapy and surgical resection in…
14 May 2026 NCT06284317
● Recruiting Phase III Oncology
Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma
What is being tested: Intravenous etentamig monotherapy is being evaluated against standard available therapies in adults with relapsed or refractory multiple myeloma to assess…
14 May 2026 NCT06158841
● Recruiting Phase III Oncology
A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.
Intervention being tested: Iptacopan, a complement factor B inhibitor, is being evaluated as an add-on therapy to standard of care in patients with generalized…
14 May 2026 NCT06517758
active not recruiting Phase III
A Study of 2 Doses of Ritlecitinib in People 12 Years of Age and Older With Alopecia Areata
Trial comparing two doses of ritlecitinib (50mg vs 100mg daily) for treating severe alopecia areata in people aged 12+.
13 May 2026 NCT06873945
active not recruiting Phase III Oncology
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
T-DXd compared to T-DM1 for HER2-positive breast cancer with residual disease after chemotherapy.
13 May 2026 NCT04622319
active not recruiting Phase III Oncology
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
Venetoclax extension study collecting long-term safety data in patients continuing to benefit from treatment.
13 May 2026 NCT03844048
● Recruiting Phase III Gastroenterology
Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein
Treatment being tested: Fazirsiran, an investigational therapy designed to reduce liver fibrosis in patients with alpha-1 antitrypsin (AAT) deficiency-related liver disease, compared against placebo.…
13 May 2026 NCT05677971
● Recruiting Phase III Cardiology / Cardiovascular
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
What is being tested: The efficacy of triple therapy (budesonide/glycopyrronium/formoterol – BGF MDI) versus dual therapy (glycopyrronium/formoterol – GFF MDI) in reducing cardiopulmonary outcomes…
13 May 2026 NCT06283966
● Recruiting Phase III Oncology
Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations
What is being tested: Datopotamab deruxtecan (Dato-DXd), a novel antibody-drug conjugate, combined with the PD-L1 inhibitor pembrolizumab versus pembrolizumab monotherapy as first-line treatment for…
13 May 2026 NCT05215340
● Recruiting Phase III
Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency
New oral medication tested in children with growth hormone deficiency to see if it works and identify who benefits most.
12 May 2026 NCT06948214