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Trial Radar

2231 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

2231 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

active not recruiting Phase III Oncology
A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer
Testing two immunotherapy combinations after chemotherapy and radiotherapy in advanced lung cancer patients.
18 Jun 2026 NCT05221840
● Recruiting Phase III Diabetes / Metabolic
Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
Treatment being tested: KAI-9531, a novel subcutaneous injection administered weekly, is being evaluated for its efficacy in reducing body weight compared to placebo in…
18 Jun 2026 NCT07284875
● Recruiting Phase III Cardiology / Cardiovascular
Timing to Restart Direct Oral Anticoagulants After Traumatic Intracranial Haemorrhage
What is being tested: The optimal timing for restarting direct oral anticoagulants (DOACs) in older patients after traumatic intracranial haemorrhage, comparing early versus delayed…
18 Jun 2026 NCT06322953
● Recruiting Phase III Cardiology / Cardiovascular
A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk
What is being tested: Lepodisiran, an investigational therapy designed to reduce lipoprotein(a) [Lp(a)] levels, is being evaluated for its ability to reduce coronary artery…
18 Jun 2026 NCT07613294
● Recruiting Phase III Oncology
A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)
Treatment being tested: Two immunotherapy-based regimens for advanced biliary tract cancer (BTC)—rilvegostomig combined with gemcitabine/cisplatin versus durvalumab combined with gemcitabine/cisplatin—compared as first-line therapy in…
18 Jun 2026 NCT07221253
active not recruiting Phase III Oncology
A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician’s Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
Giredestrant versus standard hormone therapy for early breast cancer: a Phase III trial testing a new treatment option.
18 Jun 2026 NCT04961996
active not recruiting Phase III
Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren’s Syndrome
Trial testing whether ianalumab improves symptoms and safety in people with active Sjögren's syndrome compared to placebo.
18 Jun 2026 NCT05349214
active not recruiting Phase III Infectious Disease
Attachment Inhibitor Comparison in Heavily Treatment Experienced Patients
A new HIV drug (BMS-663068) tested in patients with resistant virus who have failed multiple previous treatments.
18 Jun 2026 NCT02362503
active not recruiting Phase III Diabetes / Metabolic
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
Retatrutide weekly injection tested to reduce heart attacks, strokes, and kidney damage in obese adults over five years.
18 Jun 2026 NCT06383390
active not recruiting Phase III Cardiology / Cardiovascular
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)
CAEL-101 antibody tested to remove amyloid deposits, improve survival and reduce heart hospitalisations in advanced light chain amyloidosis patients.
18 Jun 2026 NCT04512235
active not recruiting Phase III
A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment
Imetelstat improves survival compared to standard treatment in patients with advanced myelofibrosis who haven't responded to JAK inhibitors.
18 Jun 2026 NCT04576156
active not recruiting Phase III Dermatology
A Study to Assess the Efficacy and Safety of Ruxolitinib Cream in Children and Adolescents (6 to <18 Years Old) With Moderate Atopic Dermatitis
Ruxolitinib cream safely and effectively reduced moderate eczema in children and teenagers aged 6-17 years.
17 Jun 2026 NCT06832618
active not recruiting Phase III Gastroenterology
Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis
Tofacitinib tablet oral treatment for children aged 2-17 with moderate-severe ulcerative colitis, measuring remission rates after 44 weeks.
17 Jun 2026 NCT04624230
● Recruiting Phase III Oncology
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
Treatment being tested: Dato-DXd (a HER2-directed antibody-drug conjugate) combined with rilvegostomig (an immunostimulatory agent), versus rilvegostomig alone or pembrolizumab monotherapy, as first-line therapy for…
17 Jun 2026 NCT06357533
active not recruiting Phase III Infectious Disease
Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With Biktarvy
Trial comparing a new two-drug HIV combination against standard three-drug treatment in people with well-controlled infection.
15 Jun 2026 NCT06333808
active not recruiting Phase II / Phase III Oncology
A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Participants With PIK3CA-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer
Adding inavolisib to standard breast cancer treatment improves outcomes in patients with specific genetic mutations and advanced hormone-receptor-positive disease.
15 Jun 2026 NCT04191499
● Recruiting Phase III Neurology
Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder
Radiprodil versus placebo for rare genetic brain disorder causing seizures and developmental problems, with open-label extension.
12 Jun 2026 NCT07224581
● Recruiting Phase III Dermatology
A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia
Trial testing whether subcutaneous mezagitamab maintains stable platelet counts in adults with immune thrombocytopenia compared to placebo.
12 Jun 2026 NCT06722235
● Recruiting Phase III Respiratory / COPD / Asthma
A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis
Intervention being tested: Filgotinib, a JAK1-selective inhibitor, is being evaluated for efficacy, safety, tolerability, and pharmacokinetics in paediatric and adolescent patients with ulcerative colitis…
12 Jun 2026 NCT06865417
● Recruiting Phase III Oncology
Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)
What is being tested: Belzutifan (MK-6482), a hypoxia-inducible factor (HIF-2α) inhibitor, is being evaluated in an extension study for patients with advanced solid tumors…
12 Jun 2026 NCT07405164
● Recruiting Phase III Cardiology / Cardiovascular
Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
What is being tested: Sovateltide, a neuroprotective agent designed to protect brain tissue during acute ischaemic stroke and potentially promote neural repair in the…
12 Jun 2026 NCT05691244
● Recruiting Phase III Oncology
A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy
What is being tested: IDRX-42 (GSK6042981), a novel investigational drug, is being evaluated against sunitinib (standard comparator) in adults with gastrointestinal stromal tumors (GIST)…
12 Jun 2026 NCT07218926
● Recruiting Phase III Oncology
A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study
What is being tested: Continued treatment with Roche investigational medicinal products (IMPs), either as monotherapy or in combination with other agents or comparators, in…
12 Jun 2026 NCT05862285
active not recruiting Phase III Cardiology / Cardiovascular
A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.
Inclisiran injection reduces heart attacks, strokes, and cardiovascular deaths in high-risk patients without prior heart disease, compared to placebo.
12 Jun 2026 NCT05739383
● Recruiting Phase III Diabetes / Metabolic
Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
MET097 injected once weekly helped adults with obesity or overweight lose weight over 64 weeks of treatment.
12 Jun 2026 NCT07311850
● Recruiting Phase III Oncology
An Extension Study for Patients Previously Enrolled in Studies With Pelabresib
What is being tested: Long-term safety and clinical benefit of pelabresib (a BET inhibitor) in patients with hematological and/or solid tumors, including evaluation of…
12 Jun 2026 NCT06401356
● Recruiting Phase III Rheumatology
A Study to Evaluate the Drug Levels, Efficacy and Safety of Deucravacitinib in Children and Adolescent Participants With Moderate to Severe Plaque Psoriasis
Trial testing deucravacitinib dosing, effectiveness and safety in children aged 4-17 with moderate-to-severe psoriasis over five years.
09 Jun 2026 NCT04772079
● Recruiting Phase III Oncology
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Treatment being tested: Pirtobrutinib (LOXO-305), a novel BTK inhibitor, is being compared against ibrutinib (standard BTK inhibitor) in patients with chronic lymphocytic leukaemia/small lymphocytic…
09 Jun 2026 NCT05254743
active not recruiting Phase III Neurology
Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis
Fingolimod was safer and more effective than interferon beta-1a for reducing MS relapses in children.
08 Jun 2026 NCT01892722
active not recruiting Phase III Oncology
A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Two drug combination therapy compared with single drug treatment for advanced lung cancer with specific genetic mutations.
08 Jun 2026 NCT04487080
active not recruiting Phase III
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients
Crizanlizumab at two different doses tested against placebo to reduce pain crises in adolescents and adults with sickle cell disease.
08 Jun 2026 NCT03814746
active not recruiting Phase III Oncology
A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer
Trial comparing injected versus infused amivantamab with lazertinib for EGFR-mutated lung cancer, aiming to reduce treatment time.
08 Jun 2026 NCT05388669
active not recruiting Phase III Rheumatology
A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque Psoriasis
A trial testing whether JNJ-77242113 effectively treats moderate to severe plaque psoriasis in teenagers and adults.
08 Jun 2026 NCT06095115
● Recruiting Phase III Oncology
Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC
What is being tested: A combination therapy of [225Ac]Ac-PSMA-617 (AAA817), an alpha-emitting radioligand targeting PSMA, plus an androgen receptor pathway inhibitor versus standard of…
08 Jun 2026 NCT06855277
● Recruiting Phase III Oncology
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
What is being tested: Sacituzumab tirumotecan (an antibody-drug conjugate) combined with pembrolizumab (an immune checkpoint inhibitor) as first-line maintenance therapy following chemotherapy in patients…
08 Jun 2026 NCT07216703
● Recruiting Phase III
A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)
Nipocalimab versus placebo for preventing severe haemolytic disease in at-risk pregnancies.
05 Jun 2026 NCT05912517
active not recruiting Phase III Oncology
A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy
Apalutamide with hormone therapy before and after prostate surgery improves cancer control in high-risk localised prostate cancer.
05 Jun 2026 NCT03767244
active not recruiting Phase III Oncology
A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)
Trial comparing two new bladder cancer treatments (TAR-200 with or without cetrelimab) against standard BCG therapy in untreated high-risk patients.
05 Jun 2026 NCT05714202
active not recruiting Phase III
A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa
Remibrutinib reduces symptoms of severe hidradenitis suppurativa better than placebo, with acceptable safety in adults and teenagers.
05 Jun 2026 NCT06840392
● Recruiting Phase III Rheumatology
A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn’s Disease
What is being tested: A head-to-head comparison of two IL-23 inhibitor monoclonal antibodies—guselkumab and risankizumab—to evaluate their efficacy and safety in treating moderately to…
05 Jun 2026 NCT07499232
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
What is being tested: Finerenone (a non-steroidal mineralocorticoid receptor antagonist) is being evaluated for long-term safety and efficacy when combined with standard heart failure…
05 Jun 2026 NCT07192952
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
What is being tested: Two bispecific antibody-based regimens (Tec-DR and Tal-DR) are being compared against standard daratumumab-lenalidomide-dexamethasone (DRd) therapy in newly diagnosed multiple myeloma…
05 Jun 2026 NCT05552222
● Recruiting Phase III Oncology
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
What is being tested: Amivantamab (a bispecific antibody targeting EGFR and MET) combined with pembrolizumab and carboplatin, compared to standard chemotherapy-immunotherapy combinations (pembrolizumab with…
05 Jun 2026 NCT07276399
active not recruiting Phase III
Atrasentan in Patients With IgA Nephropathy
Atrasentan reduced kidney disease progression in IgA nephropathy patients compared to placebo.
04 Jun 2026 NCT04573478
● Recruiting Phase III
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease, GM1 Gangliosidosis or GM2 Gangliosidosis
Oral nizubaglustat tested against placebo for safety and effectiveness in children with rare inherited brain storage diseases.
04 Jun 2026 NCT07054515
● Recruiting Phase III Neurology
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
XEN1101 added to existing treatment reduced seizures in patients with primary generalized tonic-clonic seizures compared to placebo.
03 Jun 2026 NCT05667142
active not recruiting Phase III Oncology
A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma
Subcutaneous injection of two cancer drugs works as well as intravenous infusion for untreated advanced melanoma.
03 Jun 2026 NCT05625399
● Recruiting Phase III
A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ – ColdU and SD)
Barzolvolimab reduces symptoms of cold-induced urticaria and dermographism better than placebo in patients uncontrolled on antihistamines.
03 Jun 2026 NCT07266402
active not recruiting Phase III Rheumatology
Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2)
Monthly ianalumab injections added to standard lupus treatment reduced disease activity better than placebo.
03 Jun 2026 NCT05624749
● Recruiting Phase III Diabetes / Metabolic
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
Orforglipron, a daily weight-loss pill, is being tested in teenagers with obesity or overweight with health complications over 18 months.
03 Jun 2026 NCT06672939