- A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer — Active Not Recruiting • Phase III • Oncology • NCT05388669.
- Trial comparing injected versus infused amivantamab with lazertinib for EGFR-mutated lung cancer, aiming to reduce treatment time.
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The purpose of the study is to simplify amivantamab intravenous administration and to reduce dose times, by assessing a new formulation of amivantamab, amivantamab subcutaneous and co-formulated with recombinant human hyaluronidase (SC-CF), for subcutaneous administration. This formulation has the potential to enhance both the patient and physician experience with amivantamab by providing easier and accelerated administration. Conditions: Advanced or Metastatic Non-small Cell Lung Cancer Interventions: Lazertinib, Amivantamab Subcutaneous and Co-Formulated with Recombinant Human Hyaluronidase (SC CF), Amivantamab Intravenous Lead Sponsor: Janssen Research & Development, LLC Planned Enrollment: 418 participants