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Clinical Trial Active — Not Recruiting Phase III NCT05221840

A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer

A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer…

📅 18 Jun 2026 ⏱ 1 min read
Active — Not Recruiting
Check the registry for current status and eligibility criteria.
Status
Active — Not Recruiting
Phase
Phase III
NCT ID
NCT05221840
Start
2022-02-07
Completion
2026-09-30
ClinicaliQ Trial Snapshot
  • A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer — Active Not Recruiting • Phase III • Oncology • NCT05221840.
  • Testing two immunotherapy combinations after chemotherapy and radiotherapy in advanced lung cancer patients.

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What This Trial Is Studying

This is a Phase III, randomised, double-blind, multicentre, international study assessing the efficacy and safety of durvalumab (MEDI4736) in combination with oleclumab (MEDI9447) or durvalumab (MEDI4736) with monalizumab (IPH2201) in adults with locally advanced (Stage III), unresectable NSCLC, who have not progressed following platinum-based cCRT. Conditions: Non-Small Cell Lung Cancer Interventions: Durvalumab, Oleclumab, Monalizumab, Placebo Lead Sponsor: AstraZeneca Planned Enrollment: 1051 participants

Full Trial Details
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Eligibility criteria, protocol, and results when available
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