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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

1963 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

1963 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

active not recruiting Phase III Oncology
A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Two drug combination therapy compared with single drug treatment for advanced lung cancer with specific genetic mutations.
08 Jun 2026 NCT04487080
active not recruiting Phase III
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients
Crizanlizumab at two different doses tested against placebo to reduce pain crises in adolescents and adults with sickle cell disease.
08 Jun 2026 NCT03814746
active not recruiting Phase III Oncology
A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer
Trial comparing injected versus infused amivantamab with lazertinib for EGFR-mutated lung cancer, aiming to reduce treatment time.
08 Jun 2026 NCT05388669
active not recruiting Phase III Rheumatology
A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque Psoriasis
A trial testing whether JNJ-77242113 effectively treats moderate to severe plaque psoriasis in teenagers and adults.
08 Jun 2026 NCT06095115
● Recruiting Phase III Oncology
Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC
What is being tested: A combination therapy of [225Ac]Ac-PSMA-617 (AAA817), an alpha-emitting radioligand targeting PSMA, plus an androgen receptor pathway inhibitor versus standard of…
08 Jun 2026 NCT06855277
● Recruiting Phase III Oncology
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
What is being tested: Sacituzumab tirumotecan (an antibody-drug conjugate) combined with pembrolizumab (an immune checkpoint inhibitor) as first-line maintenance therapy following chemotherapy in patients…
08 Jun 2026 NCT07216703
● Recruiting Phase III
A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)
Nipocalimab versus placebo for preventing severe haemolytic disease in at-risk pregnancies.
05 Jun 2026 NCT05912517
active not recruiting Phase III Oncology
A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy
Apalutamide with hormone therapy before and after prostate surgery improves cancer control in high-risk localised prostate cancer.
05 Jun 2026 NCT03767244
active not recruiting Phase III Oncology
A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)
Trial comparing two new bladder cancer treatments (TAR-200 with or without cetrelimab) against standard BCG therapy in untreated high-risk patients.
05 Jun 2026 NCT05714202
active not recruiting Phase III
A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa
Remibrutinib reduces symptoms of severe hidradenitis suppurativa better than placebo, with acceptable safety in adults and teenagers.
05 Jun 2026 NCT06840392
● Recruiting Phase III Rheumatology
A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn’s Disease
What is being tested: A head-to-head comparison of two IL-23 inhibitor monoclonal antibodies—guselkumab and risankizumab—to evaluate their efficacy and safety in treating moderately to…
05 Jun 2026 NCT07499232
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
What is being tested: Finerenone (a non-steroidal mineralocorticoid receptor antagonist) is being evaluated for long-term safety and efficacy when combined with standard heart failure…
05 Jun 2026 NCT07192952
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
What is being tested: Two bispecific antibody-based regimens (Tec-DR and Tal-DR) are being compared against standard daratumumab-lenalidomide-dexamethasone (DRd) therapy in newly diagnosed multiple myeloma…
05 Jun 2026 NCT05552222
● Recruiting Phase III Oncology
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
What is being tested: Amivantamab (a bispecific antibody targeting EGFR and MET) combined with pembrolizumab and carboplatin, compared to standard chemotherapy-immunotherapy combinations (pembrolizumab with…
05 Jun 2026 NCT07276399
active not recruiting Phase III
Atrasentan in Patients With IgA Nephropathy
Atrasentan reduced kidney disease progression in IgA nephropathy patients compared to placebo.
04 Jun 2026 NCT04573478
● Recruiting Phase III
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease, GM1 Gangliosidosis or GM2 Gangliosidosis
Oral nizubaglustat tested against placebo for safety and effectiveness in children with rare inherited brain storage diseases.
04 Jun 2026 NCT07054515
● Recruiting Phase III Neurology
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
XEN1101 added to existing treatment reduced seizures in patients with primary generalized tonic-clonic seizures compared to placebo.
03 Jun 2026 NCT05667142
active not recruiting Phase III Oncology
A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma
Subcutaneous injection of two cancer drugs works as well as intravenous infusion for untreated advanced melanoma.
03 Jun 2026 NCT05625399
● Recruiting Phase III
A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ – ColdU and SD)
Barzolvolimab reduces symptoms of cold-induced urticaria and dermographism better than placebo in patients uncontrolled on antihistamines.
03 Jun 2026 NCT07266402
active not recruiting Phase III Rheumatology
Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2)
Monthly ianalumab injections added to standard lupus treatment reduced disease activity better than placebo.
03 Jun 2026 NCT05624749
● Recruiting Phase III Diabetes / Metabolic
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
Orforglipron, a daily weight-loss pill, is being tested in teenagers with obesity or overweight with health complications over 18 months.
03 Jun 2026 NCT06672939
● Recruiting Phase III Cardiology / Cardiovascular
A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide
What is being tested: Two novel bispecific antibody combinations (talquetamab plus pomalidomide, and talquetamab plus teclistamab) are being compared against standard treatment regimens (EPd…
03 Jun 2026 NCT06208150
● Recruiting Phase III Oncology
A Study to Evaluate Glofitamab as a Single Agent vs. Investigator’s Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma
What is being tested: Glofitamab monotherapy (a CD20/CD3 bispecific antibody) is being compared against standard salvage regimens (rituximab-bendamustine or rituximab-lenalidomide) in patients with relapsed…
03 Jun 2026 NCT06084936
active not recruiting Phase III Gastroenterology
A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES)
A drug called resmetirom tested to see if it prevents liver disease progression in patients with advanced fatty liver cirrhosis.
02 Jun 2026 NCT05500222
● Recruiting Phase III
A Study to Learn More About the Effects and Long-Term Safety of Omaveloxolone (BIIB141) in Children and Teens With Friedreich’s Ataxia
Study testing omaveloxolone safety and effectiveness in children aged 2-15 with Friedreich's ataxia over three years.
02 Jun 2026 NCT06953583
active not recruiting Phase III Oncology
A Study of DB-1303/BNT323 vs Investigator’s Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)
DB-1303/BNT323 versus standard chemotherapy for HER2-low, hormone receptor positive advanced breast cancer, measuring time to disease progression.
02 Jun 2026 NCT06018337
● Recruiting Phase III Oncology
A Study of Ifinatamab Deruxtecan Versus Treatment of Physician’s Choice in Subjects With Relapsed Small Cell Lung Cancer
What is being tested: Ifinatamab deruxtecan (I-DXd), a novel antibody-drug conjugate targeting DLL3, is being compared against standard physician-selected chemotherapy in patients with relapsed…
02 Jun 2026 NCT06203210
● Recruiting Phase III Oncology
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma
What is being tested: A triple combination therapy consisting of subcutaneous epcoritamab (bispecific antibody), intravenous rituximab (monoclonal antibody), and oral lenalidomide (immunomodulatory agent) in…
02 Jun 2026 NCT06191744
active not recruiting Phase III
A Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With Spinal Muscular Atrophy
Trial testing a new add-on treatment (taldefgrobep alfa) alongside existing spinal muscular atrophy medicines to see if it helps and is safe.
01 Jun 2026 NCT05337553
active not recruiting Phase III Oncology
A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.
Adding tazemetostat to lenalidomide and rituximab improves progression-free survival in relapsed/refractory follicular lymphoma compared to placebo.
01 Jun 2026 NCT04224493
● Recruiting Phase III Oncology
Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
Treatment being tested: BNT327 (pumitamig), a novel investigational therapy, combined with standard chemotherapy (etoposide/carboplatin) versus the current standard of care atezolizumab plus chemotherapy in…
01 Jun 2026 NCT06712355
● Recruiting Phase III Oncology
A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis
Treatment being tested: Remibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, is being evaluated as an add-on therapy to standard-of-care treatment in generalised myasthenia gravis…
01 Jun 2026 NCT06744920
active not recruiting Phase III Dermatology
Study to Assess the Long-term Safety of Dupilumab Administered in Participants ≥6 Months to <18 Years of Age With Atopic Dermatitis (AD)
Long-term safety and effectiveness study of dupilumab injection in children aged six months to eighteen years with atopic dermatitis.
29 May 2026 NCT02612454
active not recruiting Phase III Neurology
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)
Remibrutinib and teriflunomide showed similar effectiveness and safety for treating relapsing multiple sclerosis.
29 May 2026 NCT05156281
active not recruiting Phase III Neurology
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)
Remibrutinib was tested against teriflunomide in relapsing MS patients to compare how well each drug works and its safety profile.
29 May 2026 NCT05147220
● Recruiting Phase III Respiratory / COPD / Asthma
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
What is being tested: Daraxonrasib (RMC-6236), a novel RAS(ON) inhibitor, is being evaluated against docetaxel chemotherapy for safety and efficacy in patients with RAS-mutated…
29 May 2026 NCT06881784
● Recruiting Phase III Cardiology / Cardiovascular
Phase 3 Clinical Study Evaluating Efficacy, Safety, and Tolerability of Obicetrapib Vs Bempedoic Acid to Treat Dyslipidemia in Adults With Primary Non-familial Hypercholesterolemia or Mixed Dyslipidemia at High to Very High Cardiovascular Risk, During a Treatment Period of Approximately 84 Days
What is being tested: Obicetrapib (OBI), a novel CETP inhibitor, is being directly compared to bempedoic acid (BPA) for reducing LDL-cholesterol in adults with…
29 May 2026 NCT07614958
● Recruiting Phase III Cardiology / Cardiovascular
A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD
What is being tested: L606 is being evaluated in a Phase 3 trial to assess its safety and efficacy in treating pulmonary hypertension secondary…
29 May 2026 NCT07285655
active not recruiting Phase III
Phase 3 Study of ALXN1850 in Treatment-Naïve Pediatric Participants With HPP
A new drug (ALXN1850) was tested against placebo in children with bone disease to see if it improves bone health.
28 May 2026 NCT06079359
● Recruiting Phase III
A Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP
A new drug (empasiprubart) is being tested to see if it safely improves symptoms in adults with chronic nerve inflammation (CIDP).
28 May 2026 NCT07091630
● Recruiting Phase III Diabetes / Metabolic
A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs
A new drug (Debio 4126) tested against placebo to control growth hormone levels in acromegaly patients previously treated with somatostatin analogs.
28 May 2026 NCT06930625
● Recruiting Phase III Oncology
AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)
What is being tested: AZD2265, a novel therapeutic agent, is being evaluated against standard-of-care treatments in patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC),…
28 May 2026 NCT07611110
● Recruiting Phase III Oncology
An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
What is being tested: Camizestrant (AZD9833), a selective oestrogen receptor degrader (SERD), is being compared to standard adjuvant endocrine therapy (aromatase inhibitors or tamoxifen)…
28 May 2026 NCT05952557
● Recruiting Phase III Oncology
A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials
What is being tested: Long-term safety profile of luspatercept (ACE-536) in patients transitioning from completed or concluded parent clinical trials, using an open-label rollover…
28 May 2026 NCT04064060
● Recruiting Phase III Oncology
A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer
What is being tested: Zolbetuximab (a monoclonal antibody targeting claudin-18.2) combined with pembrolizumab (PD-1 inhibitor) and chemotherapy as a treatment for advanced gastric and…
28 May 2026 NCT06901531
active not recruiting Phase III Oncology
Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)
DESTINY-Gastric04 Summary Trastuzumab deruxtecan improves survival compared with ramucirumab plus paclitaxel in HER2-positive gastric cancer after trastuzumab treatment.
27 May 2026 NCT04704934
active not recruiting Phase III Rheumatology
A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Study Participants With Active Psoriatic Arthritis
Bimekizumab compared to risankizumab for treating active psoriatic arthritis over 16 weeks.
27 May 2026 NCT06624228
● Recruiting Phase III
A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington’s Disease
A trial testing whether votoplam slows Huntington's disease progression in early symptomatic patients compared with placebo.
27 May 2026 NCT07326709
● Recruiting Phase III
A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)
A trial testing whether nipocalimab injection safely prevents severe low platelet counts in babies of at-risk pregnant women.
27 May 2026 NCT06533098
active not recruiting Phase III
Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta
Romosozumab versus bisphosphonates for reducing fractures and improving bone density in children with osteogenesis imperfecta over 12 months.
27 May 2026 NCT05972551