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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

2231 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

2231 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

active not recruiting Phase III Oncology
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
MRTX849 plus cetuximab compared to chemotherapy for advanced bowel cancer with specific KRAS mutation.
23 Jul 2026 NCT04793958
active not recruiting Phase III Oncology
A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy
Trial testing whether adding tiragolumab to atezolizumab improves outcomes in advanced oesophageal cancer after chemoradiotherapy.
23 Jul 2026 NCT04543617
● Recruiting Phase III Neurology
An Evaluation of Treatments for Sustained Clinical Response (18 Months) in Symptomatic Alzheimer’s Disease
What is being tested: A Phase 3 trial evaluating multiple treatment approaches for sustained clinical response over 18 months in symptomatic Alzheimer's disease, using…
23 Jul 2026 NCT07724132
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
What is being tested: The combination of finerenone (a non-steroidal mineralocorticoid receptor antagonist) plus empagliflozin (an SGLT2 inhibitor) versus standard care in hospitalised heart…
23 Jul 2026 NCT06024746
● Recruiting Phase III Oncology
EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma
Trial testing whether adding immunotherapy (pembrolizumab) to standard glioblastoma treatment improves survival compared to standard treatment alone.
22 Jul 2026 NCT06556563
● Recruiting Phase III Gastroenterology
A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD
Trial testing a surgically implanted eye device that delivers ranibizumab every 36 weeks for age-related macular degeneration.
22 Jul 2026 NCT06847542
active not recruiting Phase III Oncology
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
Pembrolizumab added to chemotherapy versus chemotherapy alone for advanced hormone receptor-positive breast cancer, with PFS as primary endpoint in PD-L1 positive patients.
22 Jul 2026 NCT04895358
● Recruiting Phase III Diabetes / Metabolic
Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes
What is being tested: Ribupatide (KAI-9531), a novel once-weekly subcutaneous injection, is being evaluated for weight reduction in people with obesity without diabetes, compared…
22 Jul 2026 NCT07284979
● Recruiting Phase III Oncology
DAREON®-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer (epNEC) to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy
What is being tested: Obrixtamig (a DLL3-targeting therapy) combined with carboplatin and etoposide chemotherapy versus standard chemotherapy alone in patients with advanced extrapulmonary neuroendocrine…
22 Jul 2026 NCT07544654
● Recruiting Phase III
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of GM1 Gangliosidosis or GM2 Gangliosidosis
Oral nizubaglustat tested against placebo over 18 months in children with late-infantile or juvenile GM1/GM2 gangliosidosis.
21 Jul 2026 NCT07082543
active not recruiting Phase III Oncology
A Clinical Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) to Treat Newly-diagnosed Metastatic Non-small Cell Lung Cancer (MK-3475A-F84)
Trial comparing subcutaneous versus intravenous pembrolizumab delivery for newly-diagnosed metastatic non-small cell lung cancer.
21 Jul 2026 NCT06698042
● Recruiting Phase III
A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP
Trial comparing new drug empasiprubart against standard IVIg treatment for CIDP over 24 weeks, then all patients receive empasiprubart for 24 months.
21 Jul 2026 NCT06920004
active not recruiting Phase III Rheumatology
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
A drug called obinutuzumab added to standard lupus kidney treatment improved kidney function and was safe compared to placebo.
21 Jul 2026 NCT04221477
● Recruiting Phase III Respiratory / COPD / Asthma
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
Treatment being tested: Tozorakimab (a monoclonal antibody) administered as an add-on to standard care in hospitalised patients with viral lung infection requiring supplemental oxygen,…
21 Jul 2026 NCT05624450
● Recruiting Phase III Oncology
AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer
What is being tested: AZD5335 (a folate receptor alpha inhibitor) is compared against mirvetuximab soravtansine in FRα-high tumours and against chemotherapy in FRα-low tumours,…
21 Jul 2026 NCT07218809
active not recruiting Phase III
24 Weeks Double-blind Randomized Placebo-controlled Trial to Evaluate Efficacy, PK, Safety of LOU064 in Adolescents (12 – <18) With CSU and Inadequate Response to H1-antihistamine Followed by Optional 3 Years Open-label Extension and an Optional 3 Years Safety Long-term Treatment-free Follow-up
Remibrutinib versus placebo for adolescent chronic urticaria inadequately controlled by antihistamines, with long-term safety follow-up.
20 Jul 2026 NCT05677451
● Recruiting Phase III Oncology
A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)
What is being tested: The trial evaluates belzutifan (MK-6482), a targeted therapy already used for RCC, combined with zanzalintinib (a new investigational agent) to…
20 Jul 2026 NCT07489495
● Recruiting Phase III Respiratory / COPD / Asthma
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)
GB-0895 is being tested as an add-on therapy for adolescents and adults with severe asthma that remains uncontrolled despite treatment with inhaled corticosteroids and…
20 Jul 2026 NCT07359846
active not recruiting Phase III Oncology
Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer
New drug combination XL092 plus atezolizumab compared to regorafenib for advanced bowel cancer that hasn't responded to standard treatment.
17 Jul 2026 NCT05425940
active not recruiting Phase III
A Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With Dermatomyositis
Brepocitinib, a new immune-suppressing drug, tested against placebo in adults with dermatomyositis over 52 weeks.
17 Jul 2026 NCT05437263
active not recruiting Phase III
A Study to Assess Safety, Tolerability and Efficacy of Garetosmab Versus Placebo Administered Intravenously (IV) in Adult Participants With Fibrodysplasia Ossificans Progressiva (FOP)
Garetosmab injection tested against placebo in adults with FOP to assess safety and effectiveness at slowing bone formation.
17 Jul 2026 NCT05394116
● Recruiting Phase III
An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED
Cenegermin eye drops versus placebo for treating persistent corneal erosion, measuring complete healing at four weeks.
16 Jul 2026 NCT07519902
active not recruiting Phase III Oncology
A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW).
Zolbetuximab plus chemotherapy versus placebo plus chemotherapy for first-line treatment of advanced gastric or gastroesophageal junction cancer positive for Claudin 18.2.
16 Jul 2026 NCT03653507
● Recruiting Phase III Oncology
A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy
What is being tested: Oral upadacitinib (a JAK inhibitor) is being evaluated for safety and efficacy in treating moderate to severe hidradenitis suppurativa in…
16 Jul 2026 NCT05889182
active not recruiting Phase III Neurology
A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-remitting Multiple Sclerosis (RRMS)
Ocrelizumab versus fingolimod for treating multiple sclerosis in children and teenagers over 24 weeks.
15 Jul 2026 NCT05123703
● Recruiting Phase III Oncology
VO and Nivolumab vs Physician’s Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]
IGNYTE-3 Trial Summary VO plus nivolumab versus standard treatment for melanoma that progressed after checkpoint inhibitor therapy.
15 Jul 2026 NCT06264180
● Recruiting Phase III Respiratory / COPD / Asthma
A Study to See if Tolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
What is being tested: Tolvaptan (a vasopressin V2-receptor antagonist) is being evaluated for safety and pharmacodynamic effects in infants and children aged 28 days…
15 Jul 2026 NCT04782258
● Recruiting Phase III Diabetes / Metabolic
Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
What is being tested: Ribupatide (KAI-9531), a once-weekly subcutaneous injection, is being evaluated for its efficacy in reducing body weight and improving glycaemic control…
15 Jul 2026 NCT07284901
● Recruiting Phase III Diabetes / Metabolic
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
Being tested: Elecoglipron (a novel therapeutic agent) versus placebo in patients with type 2 diabetes who have impaired renal function, all receiving background dapagliflozin…
15 Jul 2026 NCT07662135
● Recruiting Phase III Diabetes / Metabolic
A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
What is being tested: The study investigates a dual-agent combination therapy of elecoglipron (a GLP-1 receptor agonist) plus dapagliflozin (an SGLT2 inhibitor) versus each…
15 Jul 2026 NCT07662109
● Recruiting Phase III Oncology
Personalising Treatment for Myeloma Patients Based on Initial Response to NHS Treatment and Their Overall Fitness Level
What is being tested: The iFIT trial evaluates personalised treatment strategies for newly diagnosed myeloma patients who are ineligible for stem cell transplantation, with…
15 Jul 2026 NCT07649525
● Recruiting Phase III
Efficacy, Safety, and Tolerability of Zeleciment Basivarsen (DYNE-101) in Participants With Myotonic Dystrophy Type 1
A drug called zeleciment basivarsen was tested to see if it safely and effectively treats myotonic dystrophy type 1.
14 Jul 2026 NCT07486934
active not recruiting Phase III Oncology
Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer
Durvalumab alone or combined with tremelimumab compared to chemotherapy for advanced bladder cancer.
14 Jul 2026 NCT02516241
● Recruiting Phase III
A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine
Eptinezumab reduced migraine days more than placebo in teenagers aged 12-17 with chronic migraine.
14 Jul 2026 NCT04965675
● Recruiting Phase III
A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Children (6 to < 12 Years Old) With Nonsegmental Vitiligo
Ruxolitinib cream safely and effectively treats vitiligo in children aged 6-12 years.
14 Jul 2026 NCT06804811
active not recruiting Phase III
Trial of Sibeprenlimab in the Treatment of A Nephropathy (IgAN)
A drug injected under the skin was tested to see if it could reduce kidney damage and was safe in patients with IgA nephropathy.
14 Jul 2026 NCT05248646
● Recruiting Phase III
A Study of Eptinezumab in Pediatric Participants With Episodic Migraine
Eptinezumab reduced migraine days in children with episodic migraine.
14 Jul 2026 NCT05897320
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
What is being tested: Elecoglipron, a novel investigational drug, is being evaluated against oral semaglutide (an established GLP-1 receptor agonist) for efficacy, safety, and…
14 Jul 2026 NCT07662213
● Recruiting Phase III Oncology
Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
What is being tested: Zanidatamab (a HER2-directed bispecific antibody) combined with standard chemotherapy (Cisplatin/Gemcitabine ± PD-1/L1 inhibitor) versus chemotherapy alone in advanced HER2-positive biliary…
14 Jul 2026 NCT06282575
active not recruiting Phase III Oncology
A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy
A new drug combination (ceralasertib plus durvalumab) tested against standard chemotherapy in advanced lung cancer patients whose disease progressed despite previous immunotherapy.
13 Jul 2026 NCT05450692
active not recruiting Phase III Oncology
A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer
Trial comparing a new drug combination (Dato-DXd plus durvalumab) against standard chemotherapy plus pembrolizumab for triple-negative breast cancer.
13 Jul 2026 NCT06112379
active not recruiting Phase III Oncology
Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)
Adding rilvegostomig to standard chemotherapy after biliary tract cancer surgery may improve outcomes compared to chemotherapy alone.
10 Jul 2026 NCT06109779
● Recruiting Phase III Diabetes / Metabolic
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
What is being tested: Elecoglipron, a novel therapeutic agent, is being evaluated for efficacy and safety in reducing weight in adults with obesity or…
10 Jul 2026 NCT07667803
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
What is being tested: Finerenone (a non-steroidal mineralocorticoid receptor antagonist) versus placebo in patients with heart failure and reduced ejection fraction (HFrEF) to evaluate…
10 Jul 2026 NCT06033950
active not recruiting Phase III Oncology
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Osimertinib (TAGRISSO) (ROSY-T)
Osimertinib continuation study for cancer patients benefiting from treatment in previous trials.
09 Jul 2026 NCT05629234
active not recruiting Phase III Diabetes / Metabolic
Extension Trial Evaluating the Long-term Safety and Efficacy of Dasiglucagon in Children With Congenital Hyperinsulinism
Long-term safety study of dasiglucagon injections in children with congenital hyperinsulinism, following earlier trial completion. (Word count: 19)
09 Jul 2026 NCT03941236
active not recruiting Phase III
Long-term Follow-up of Patients With Spinal Muscular Atrophy Treated With OAV101 in Clinical Trials
Patients who received OAV101 for spinal muscular atrophy are being monitored for five years to check long-term safety and effectiveness.
09 Jul 2026 NCT05335876
● Recruiting Phase III Oncology
Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV)
What is being tested: Surovatamig (a subcutaneous monoclonal antibody) administered as consolidation therapy following initial treatment in patients with CLL/SLL, focusing on therapeutic efficacy…
09 Jul 2026 NCT07509151
active not recruiting Phase III Oncology
177Lu-PSMA-617 vs. Androgen Receptor-Directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer
Radioactive lutetium treatment improved survival compared to hormone therapy in men with advanced prostate cancer resistant to standard hormonal treatment.
08 Jul 2026 NCT04689828
active not recruiting Phase III
Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)
Depemokimab was compared to mepolizumab for treating difficult-to-control EGPA in adults already on standard treatment.
08 Jul 2026 NCT05263934