- Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder — Recruiting • Phase III • Neurology • NCT07224581.
- Radiprodil versus placebo for rare genetic brain disorder causing seizures and developmental problems, with open-label extension.
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- Quick orientation before opening the registry record.
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The Phase 3 portion of Study RAD-GRIN-101 is a multinational, multicenter, randomized, double-blind, placebo-controlled trial followed by an open-label extension to evaluate the efficacy and safety of radiprodil in participants with GRIN-related neurodevelopmental disorder (GRIN-NDD) with a gain-of-function (GoF) genetic variant. This study will enroll two cohorts: one cohort of participants with a minimal number of countable motor seizures (with or without behavioral symptoms) (Phase 3 Cohort 1: Qualifying Seizures Cohort); and a second cohort with disease symptoms but no seizures or fewer seizures than required for the Qualifying Seizures…