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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

1963 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

1963 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

● Recruiting Phase III Oncology
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
Treatment Being Tested: Ivonescimab (a dual TIGIT/PD-L1 pathway inhibitor) combined with chemotherapy compared to pembrolizumab (PD-L1 inhibitor) combined with chemotherapy as first-line therapy for…
30 Apr 2026 NCT05899608
● Recruiting Phase III Cardiology / Cardiovascular
Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)
Treatment being tested: ADX-324 is a novel therapy being evaluated for long-term safety and efficacy in hereditary angioedema (HAE) Types I and II, building…
30 Apr 2026 NCT07428499
● Recruiting Phase III Oncology
A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)
What is being tested: AZD0120, a dual-targeted CAR-T cell therapy targeting both BCMA and CD19 antigens, is being compared against standard chemotherapy regimens (daratumumab-based…
30 Apr 2026 NCT07391657
● Recruiting Phase III Oncology
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
What is being tested: Quizartinib (a FLT3 inhibitor) plus standard chemotherapy versus placebo plus chemotherapy in newly diagnosed FLT3-ITD negative AML patients to determine…
30 Apr 2026 NCT06578247
● Recruiting Phase III Oncology
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
What is being tested: A randomised comparison of two triple-drug regimens—mezigdomide (a novel cereblon modulator) combined with bortezomib and dexamethasone versus the established pomalidomide…
30 Apr 2026 NCT05519085
active not recruiting Phase III
A Randomized, Double-blind 2-arm, Followed by an Open-label 1-arm, NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.
Long-term safety and effectiveness study of ianalumab, a new drug treatment for patients with Sjögren's syndrome.
29 Apr 2026 NCT05985915
● Recruiting Phase III
Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN
Iptacopan reduces kidney damage better than placebo in patients with a specific type of glomerulonephritis.
29 Apr 2026 NCT05755386
● Recruiting Phase III
A Study to Assess the Efficacy and Safety of Efgartigimod IV in Adult Participants With Primary Immune Thrombocytopenia
Study testing intravenous efgartigimod versus placebo in adults with immune thrombocytopenia to assess effectiveness and safety.
29 Apr 2026 NCT06544499
● Recruiting Phase III
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
Xeomin injections tested against placebo for reducing monthly migraine days in chronic migraine patients over one year.
29 Apr 2026 NCT07018713
active not recruiting Phase III Neurology
A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.
ZX008 reduced seizures in children and adults with CDKL5 deficiency disorder compared to placebo.
29 Apr 2026 NCT05064878
active not recruiting Phase III Dermatology
A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo
52-week trial testing whether continuing or increasing ritlecitinib dosing maintains or improves skin pigmentation recovery in non-segmental vitiligo patients.
29 Apr 2026 NCT06163326
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
What is being tested: Finerenone (a non-steroidal mineralocorticoid receptor antagonist) versus placebo in hospitalized patients with acute decompensated heart failure, specifically targeting those with…
29 Apr 2026 NCT06008197
● Recruiting Phase III Oncology
Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer
Intervention being tested: Sacituzumab govitecan (an antibody-drug conjugate targeting Trop-2) compared against standard of care chemotherapy in patients with previously treated extensive-stage small cell…
29 Apr 2026 NCT06801834
● Recruiting Phase III Oncology
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
What is being tested: Datopotamab deruxtecan (Dato-DXd), a TROP2-targeted antibody-drug conjugate, is being compared against standard docetaxel chemotherapy in previously treated advanced/metastatic non-squamous NSCLC…
29 Apr 2026 NCT07291037
● Recruiting Phase III
Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation
Ravulizumab drug reduced need for dialysis after kidney transplant compared to placebo in high-risk patients.
28 Apr 2026 NCT06830798
● Recruiting Phase III
A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)
Enlicitide added to rosuvastatin reduced cholesterol more than rosuvastatin alone in high cholesterol patients.
28 Apr 2026 NCT07216482
● Recruiting Phase III Respiratory / COPD / Asthma
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer’s Disease (ADEPT-2)
Treatment being tested: KarXT, a novel muscarinic M1/M4 receptor agonist, is being evaluated for treating psychosis (including hallucinations, delusions, and agitation) in patients with…
28 Apr 2026 NCT06126224
● Recruiting Phase III Oncology
MITHRIDATE: Ruxolitinib Versus Hydroxycarbamide or Interferon as First Line Therapy in High Risk Polycythemia Vera
Treatment being tested: Ruxolitinib (a JAK1/2 inhibitor) compared against standard first-line therapies (hydroxycarbamide or interferon-alpha) in newly diagnosed high-risk polycythemia vera patients. Patient eligibility…
28 Apr 2026 NCT04116502
● Recruiting Phase III Oncology
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator’s Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
What is being tested: Nemtabrutinib (MK-1026), a novel Bruton's tyrosine kinase (BTK) inhibitor, is being directly compared against standard-of-care BTK inhibitors (ibrutinib or acalabrutinib)…
28 Apr 2026 NCT06136559
● Recruiting Phase III Gastroenterology
Extension Study for the Port Delivery System With Ranibizumab (Portal)
Portal Extension Study Summary Implanted drug delivery system releasing ranibizumab shows sustained safety and effectiveness in wet age-related macular degeneration over extended follow-up.
27 Apr 2026 NCT03683251
● Recruiting Phase II / Phase III
A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation
Frexalimab injections compared to tacrolimus tablets in first kidney transplant patients over five years to assess effectiveness and safety.
27 Apr 2026 NCT07412470
● Recruiting Phase III Rheumatology
OLE Study With Filgotinib in JIA
Filgotinib appears safe and effective for long-term use in children with polyarticular or systemic juvenile idiopathic arthritis.
27 Apr 2026 NCT07553182
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease
What is being tested: Roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor already approved for treating anaemia in adult CKD patients, is being investigated…
27 Apr 2026 NCT05970172
● Recruiting Phase III Infectious Disease
A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT
What is being tested: This Phase 3 trial compares two intravenous antiviral treatments—brincidofovir (BCV) and cidofovir (CDV)—for managing adenovirus (AdV) viremia in allogeneic hematopoietic…
27 Apr 2026 NCT07387367
● Recruiting Phase III Oncology
Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer
What is being tested: The trial evaluates whether adding stereotactic radiosurgery (SRS) to standard systemic immunotherapy or targeted therapy improves central nervous system progression-free…
27 Apr 2026 NCT05522660
● Recruiting Phase III Oncology
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
What is being tested: JNJ-90301900 (NBTXR3), a nanoparticle therapy activated by radiotherapy, combined with standard radiation therapy ± cetuximab versus radiation therapy ± cetuximab…
27 Apr 2026 NCT04892173
● Recruiting Phase III Oncology
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
What is being tested: The addition of INCB161734 (a KRAS G12D inhibitor) to standard chemotherapy versus chemotherapy alone in patients with metastatic pancreatic cancer…
27 Apr 2026 NCT07522073
● Recruiting Phase III
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
New anti-inflammatory injection (itepekimab) tested alongside steroid nasal spray for difficult-to-treat nasal polyps over one year.
24 Apr 2026 NCT06834360
● Recruiting Phase III
REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome
ION582 improved seizures, sleep and developmental outcomes in Angelman syndrome patients with UBE3A deletions or mutations.
24 Apr 2026 NCT06914609
active not recruiting Phase II / Phase III
An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)
Diacerein ointment tested for safety and effectiveness in treating generalized epidermolysis bullosa simplex blistering disorder.
24 Apr 2026 NCT06073132
● Recruiting Phase III Gastroenterology
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
What is being tested: Efruxifermin (EFX), an FGF21 analogue, is being evaluated in a randomized controlled trial to assess its efficacy and safety in…
24 Apr 2026 NCT06528314
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Migalastat in Pediatric Subjects (2 to
What is being tested: Migalastat, a pharmacological chaperone, is being evaluated for safety, pharmacokinetics, pharmacodynamics, and efficacy in treating paediatric Fabry disease patients aged…
24 Apr 2026 NCT06904261
● Recruiting Phase III Oncology
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
What is being tested: ARTEMIDE-Lung04 evaluates rilvegostomig (a novel immunotherapy agent) versus pembrolizumab monotherapy as first-line treatment in patients with metastatic non-small cell lung…
24 Apr 2026 NCT06868277
● Recruiting Phase III Oncology
Mocravimod as Adjunctive and Maintenance Treatment in AML Patients Undergoing Allo-HCT
What is being tested: Mocravimod, a TLR7 agonist, is being evaluated as an adjunctive and maintenance therapy in acute myeloid leukaemia (AML) patients undergoing…
24 Apr 2026 NCT05429632
● Recruiting Phase III Oncology
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
What is being tested: Long-term safety and efficacy of pembrolizumab (an anti-PD-1 immunotherapy) in patients with advanced tumors who are continuing treatment or follow-up…
24 Apr 2026 NCT03486873
● Recruiting Phase II / Phase III
A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)
A trial testing whether an oral cholesterol-lowering drug is safe and effective in children and teenagers with familial high cholesterol.
23 Apr 2026 NCT07058077
active not recruiting Phase III Oncology
A Global Study to Assess the Effects of Osimertinib in Participants With EGFRm Stage IA2-IA3 NSCLC Following Complete Tumour Resection
Osimertinib after surgery improves survival in early-stage lung cancer patients with specific EGFR mutations.
23 Apr 2026 NCT05120349
active not recruiting Phase II / Phase III
A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)
Mitapivat tested in sickle cell patients to increase haemoglobin levels and reduce painful crisis episodes compared to placebo.
23 Apr 2026 NCT05031780
● Recruiting Phase III Gastroenterology
A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis
Trial testing a new drug (Afimkibart) for treating moderate-to-severe ulcerative colitis in children, measuring safety and effectiveness.
23 Apr 2026 NCT07158242
● Recruiting Phase III Respiratory / COPD / Asthma
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
What is being tested: Depemokimab, a monoclonal antibody, is being evaluated for its effects on airway structure and function in asthma patients using imaging…
23 Apr 2026 NCT06979323
● Recruiting Phase III Oncology
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
Treatment being tested: Sonrotoclax (a BCL2 inhibitor) combined with zanubrutinib (a BTK inhibitor) versus placebo plus zanubrutinib alone in adults with relapsed/refractory mantle cell…
23 Apr 2026 NCT06742996
● Recruiting Phase III Oncology
Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)
What is being tested: Sacituzumab tirumotecan (an antibody-drug conjugate targeting Trop-2) compared against standard chemotherapy (docetaxel or pemetrexed) in previously-treated advanced/metastatic nonsquamous NSCLC patients…
23 Apr 2026 NCT06074588
● Recruiting Phase III Oncology
A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC
Treatment being tested: Durvalumab combined with domvanalimab (a novel anti-CTLA-4 immune checkpoint inhibitor) versus durvalumab alone, given after concurrent chemoradiation in patients with unresectable…
23 Apr 2026 NCT05211895
active not recruiting Phase III
Efficacy and Safety in Imlifidase Desensitized Kidney Tx Patients, Including Two Non-Comparative Reference Cohorts
Imlifidase allows highly sensitized kidney transplant patients with positive crossmatch to receive transplants safely, with good one-year graft survival.
22 Apr 2026 NCT05369975
● Recruiting Phase III Mental Health / Psychiatry
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
New psilocin-based drug CYB003 tested against placebo for treating depression as an add-on therapy.
22 Apr 2026 NCT06793397
active not recruiting Phase III
Study of Ianalumab Versus Placebo in Addition to First-line Corticosteroids in Primary Immune Thrombocytopenia (ITP)
Ianalumab added to steroids didn't improve platelet counts better than steroids alone in newly diagnosed ITP patients.
22 Apr 2026 NCT05653349
● Recruiting Phase III Oncology
A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC)
Drug being tested: GSK5764227 (Risvutatug rezetecan/Ris-Rez) is a novel B7-H3-targeted therapy designed to inhibit cancer cell growth and metastasis in patients with relapsed small…
22 Apr 2026 NCT07099898
● Recruiting Phase III Cardiology / Cardiovascular
Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial – Part 2
What is being tested: Recombinant Factor VIIa (rFVIIa) as a potential therapeutic intervention to halt hematoma expansion and improve outcomes in patients with acute…
22 Apr 2026 NCT07227246
● Recruiting Phase III Cardiology / Cardiovascular
STOP-HAE: A Phase 3 Study of ADX-324 in HAE
What is being tested: ADX-324, a novel therapeutic agent, is being evaluated in a Phase 3 trial to assess its efficacy and safety in…
22 Apr 2026 NCT06960213
● Recruiting Phase III Oncology
A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
What is being tested: BGB-16673, a novel BTK inhibitor, is being evaluated against pirtobrutinib (an established BTK inhibitor) in patients with relapsed/refractory CLL or…
22 Apr 2026 NCT06973187