Oncology Cardiology / Cardiovascular Respiratory / COPD / Asthma Infectious Disease Gastroenterology Neurology Diabetes / Metabolic Women's Health Rheumatology Mental Health / Psychiatry Dermatology Rare Diseases Men's Health
Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

2236 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

2236 recruiting AI clinical summaries
Explore Trial Collections Follow research updates
All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
🔬
Trial Radar

Clinical Trial Intelligence

● Recruiting Phase III
A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy
What is being tested: Long-term safety and tolerability of iptacopan (LNP023), a complement Factor B inhibitor, in an open-label extension program for patients with…
06 May 2026 NCT04557462
● Recruiting Phase III Oncology
A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator’s Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer
Drug Being Tested: BMS-986365 is being evaluated against standard investigator-selected therapies in a comparative efficacy and safety trial for metastatic castration-resistant prostate cancer (mCRPC).…
06 May 2026 NCT06764485
● Recruiting Phase III Oncology
Neoadjuvant Darovasertib in Primary Uveal Melanoma
What is being tested: Darovasertib, a PKC412 inhibitor, administered before surgery (neoadjuvant approach) in patients with primary uveal melanoma to assess efficacy in reducing…
06 May 2026 NCT07015190
active not recruiting Phase III Infectious Disease
Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F/TAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex With Men and Are At Risk of HIV-1 Infection
Daily F/TAF tablet prevents HIV infection in high-risk men and transgender women compared with F/TDF.
05 May 2026 NCT02842086
active not recruiting Phase III
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
Belzutifan plus lenvatinib compared to cabozantinib for treating advanced kidney cancer after prior treatment.
05 May 2026 NCT04586231
active not recruiting Phase III Oncology
Trial to Evaluate Acasunlimab and Pembrolizumab Combination Superiority Over Standard of Care Docetaxel in Non-Small Cell Lung Cancer (ABBIL1TY NSCLC-06)
New drug combination tested against standard chemotherapy in advanced lung cancer patients who've had prior immunotherapy and chemotherapy.
05 May 2026 NCT06635824
● Recruiting Phase III Oncology
The Study of 177Lu-TLX591 Plus SOC Versus SOC Alone in Patients With mCRPC (ProstACT Global)
What is being tested: 177Lu-TLX591, a targeted radioligand therapy, is being evaluated in combination with standard of care versus standard of care alone in…
05 May 2026 NCT06520345
● Recruiting Phase III Gastroenterology
A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)
What is being tested: Pegozafermin (a FGF21 analogue) at two different dose regimens versus placebo for treating liver fibrosis (stages F2–F3) in adults with…
05 May 2026 NCT06318169
● Recruiting Phase III Respiratory / COPD / Asthma
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn’s Disease (CD)
What is being tested: Vedolizumab, an anti-inflammatory biologic agent targeting gut-specific integrin α4β7, is being evaluated for efficacy and safety in paediatric patients (children…
05 May 2026 NCT04779320
● Recruiting Phase III Cardiology / Cardiovascular
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
What is being tested: Omecamtiv mecarbil (CK-1827452), an investigational cardiac myosin activator, is being evaluated to determine if it reduces adverse outcomes including hospitalisation,…
05 May 2026 NCT06736574
● Recruiting Phase III Oncology
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
What is being tested: ALLTogether is a master protocol that consolidates evidence-based treatment approaches for acute lymphoblastic leukaemia (ALL) across infants, children, and young…
05 May 2026 NCT04307576
active not recruiting Phase III
A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA)
Monthly eye injections of vonaprument tested to slow vision loss in dry age-related macular degeneration with geographic atrophy.
04 May 2026 NCT06510816
● Recruiting Phase III Gastroenterology
A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis
A new drug called Afimkibart is being tested to see if it safely treats moderate to severe ulcerative colitis better than placebo.
04 May 2026 NCT06588855
active not recruiting Phase III
A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56
Two-year trial testing EYP-1901 against aflibercept for wet age-related macular degeneration, with main results at one year.
04 May 2026 NCT06683742
● Recruiting Phase III Gastroenterology
A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn’s Disease
New drug afimkibart tested for safely treating moderate-to-severe Crohn's disease in a phase three trial comparing it against placebo.
04 May 2026 NCT06819878
active not recruiting Phase III
Oral N-acetylcysteine for Retinitis Pigmentosa
NAC supplement may slow vision loss in retinitis pigmentosa by reducing oxidative stress; ongoing trials testing long-term effectiveness.
04 May 2026 NCT05537220
● Recruiting Phase III
A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease
Rilzabrutinib reduces disease flares and controls IgG4-related disease activity better than placebo over 52 weeks in adults.
04 May 2026 NCT07190196
● Recruiting Phase III Respiratory / COPD / Asthma
A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
What is being tested: The efficacy and safety of axatilimab (a CD40 ligand antagonist) combined with corticosteroids versus placebo plus corticosteroids as first-line treatment…
04 May 2026 NCT06585774
● Recruiting Phase III Oncology
Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation
What is being tested: Revumenib, a menin inhibitor, combined with intensive chemotherapy versus chemotherapy alone in newly diagnosed AML patients with NPM1 mutations, evaluating…
04 May 2026 NCT07211958
● Recruiting Phase III Rheumatology
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
Dapirolizumab pegol added to standard treatment improves moderate to severe lupus disease activity.
01 May 2026 NCT06617325
active not recruiting Phase III Oncology
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)
Adding pembrolizumab immunotherapy to chemoradiotherapy improves survival and delays cancer progression in muscle-invasive bladder cancer patients avoiding surgery.
01 May 2026 NCT04241185
active not recruiting Phase III Gastroenterology
Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)
Elafibranor tested against placebo in PBC patients inadequately responding to ursodeoxycholic acid, assessing alkaline phosphatase reduction and safety.
01 May 2026 NCT04526665
active not recruiting Phase III Oncology
Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
Two immunotherapy drugs versus standard chemotherapy for advanced lung cancer without specific genetic mutations.
01 May 2026 NCT02542293
active not recruiting Phase III Neurology
A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
Long-term safety and efficacy study of ocrelizumab, a B-cell depleting antibody, in multiple sclerosis patients continuing from previous trials.
01 May 2026 NCT05269004
active not recruiting Phase III Mental Health / Psychiatry
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Panorama)
MM120 was tested against placebo for anxiety disorder in a large, rigorous trial with long-term follow-up.
01 May 2026 NCT06809595
active not recruiting Phase III Gastroenterology
A Study of Elafibranor in Adults With Primary Biliary Cholangitis and Inadequate Response or Intolerance to Ursodeoxycholic Acid.
Trial testing elafibranor versus placebo in primary biliary cholangitis patients who cannot tolerate or inadequately respond to ursodeoxycholic acid, measuring effects on alkaline phosphatase…
30 Apr 2026 NCT06383403
active not recruiting Phase III
A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment
Two new PNH drugs (pozelimab + cemdisiran) tested for safety and effectiveness against existing complement inhibitor treatments.
30 Apr 2026 NCT05133531
● Recruiting Phase III Oncology
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician’s Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Treatment being tested: Sacituzumab govitecan-hziy (an antibody-drug conjugate targeting Trop-2) combined with pembrolizumab (PD-L1 inhibitor) versus physician's choice treatment in the adjuvant setting following…
30 Apr 2026 NCT05633654
● Recruiting Phase III Oncology
Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen
What is being tested: Paltusotine, an oral daily medication, is being evaluated against placebo in a Phase 3 randomized controlled trial to assess its…
30 Apr 2026 NCT07087054
● Recruiting Phase III Oncology
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
Treatment Being Tested: Ivonescimab (a dual TIGIT/PD-L1 pathway inhibitor) combined with chemotherapy compared to pembrolizumab (PD-L1 inhibitor) combined with chemotherapy as first-line therapy for…
30 Apr 2026 NCT05899608
● Recruiting Phase III Cardiology / Cardiovascular
Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)
Treatment being tested: ADX-324 is a novel therapy being evaluated for long-term safety and efficacy in hereditary angioedema (HAE) Types I and II, building…
30 Apr 2026 NCT07428499
● Recruiting Phase III Oncology
A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)
What is being tested: AZD0120, a dual-targeted CAR-T cell therapy targeting both BCMA and CD19 antigens, is being compared against standard chemotherapy regimens (daratumumab-based…
30 Apr 2026 NCT07391657
● Recruiting Phase III Oncology
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
What is being tested: Quizartinib (a FLT3 inhibitor) plus standard chemotherapy versus placebo plus chemotherapy in newly diagnosed FLT3-ITD negative AML patients to determine…
30 Apr 2026 NCT06578247
● Recruiting Phase III Oncology
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
What is being tested: A randomised comparison of two triple-drug regimens—mezigdomide (a novel cereblon modulator) combined with bortezomib and dexamethasone versus the established pomalidomide…
30 Apr 2026 NCT05519085
active not recruiting Phase III
A Randomized, Double-blind 2-arm, Followed by an Open-label 1-arm, NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.
Long-term safety and effectiveness study of ianalumab, a new drug treatment for patients with Sjögren's syndrome.
29 Apr 2026 NCT05985915
● Recruiting Phase III
Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN
Iptacopan reduces kidney damage better than placebo in patients with a specific type of glomerulonephritis.
29 Apr 2026 NCT05755386
● Recruiting Phase III
A Study to Assess the Efficacy and Safety of Efgartigimod IV in Adult Participants With Primary Immune Thrombocytopenia
Study testing intravenous efgartigimod versus placebo in adults with immune thrombocytopenia to assess effectiveness and safety.
29 Apr 2026 NCT06544499
● Recruiting Phase III
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
Xeomin injections tested against placebo for reducing monthly migraine days in chronic migraine patients over one year.
29 Apr 2026 NCT07018713
active not recruiting Phase III Neurology
A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.
ZX008 reduced seizures in children and adults with CDKL5 deficiency disorder compared to placebo.
29 Apr 2026 NCT05064878
active not recruiting Phase III Dermatology
A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo
52-week trial testing whether continuing or increasing ritlecitinib dosing maintains or improves skin pigmentation recovery in non-segmental vitiligo patients.
29 Apr 2026 NCT06163326
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
What is being tested: Finerenone (a non-steroidal mineralocorticoid receptor antagonist) versus placebo in hospitalized patients with acute decompensated heart failure, specifically targeting those with…
29 Apr 2026 NCT06008197
● Recruiting Phase III Oncology
Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer
Intervention being tested: Sacituzumab govitecan (an antibody-drug conjugate targeting Trop-2) compared against standard of care chemotherapy in patients with previously treated extensive-stage small cell…
29 Apr 2026 NCT06801834
● Recruiting Phase III Oncology
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
What is being tested: Datopotamab deruxtecan (Dato-DXd), a TROP2-targeted antibody-drug conjugate, is being compared against standard docetaxel chemotherapy in previously treated advanced/metastatic non-squamous NSCLC…
29 Apr 2026 NCT07291037
● Recruiting Phase III
Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation
Ravulizumab drug reduced need for dialysis after kidney transplant compared to placebo in high-risk patients.
28 Apr 2026 NCT06830798
● Recruiting Phase III
A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)
Enlicitide added to rosuvastatin reduced cholesterol more than rosuvastatin alone in high cholesterol patients.
28 Apr 2026 NCT07216482
● Recruiting Phase III Respiratory / COPD / Asthma
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer’s Disease (ADEPT-2)
Treatment being tested: KarXT, a novel muscarinic M1/M4 receptor agonist, is being evaluated for treating psychosis (including hallucinations, delusions, and agitation) in patients with…
28 Apr 2026 NCT06126224
● Recruiting Phase III Oncology
MITHRIDATE: Ruxolitinib Versus Hydroxycarbamide or Interferon as First Line Therapy in High Risk Polycythemia Vera
Treatment being tested: Ruxolitinib (a JAK1/2 inhibitor) compared against standard first-line therapies (hydroxycarbamide or interferon-alpha) in newly diagnosed high-risk polycythemia vera patients. Patient eligibility…
28 Apr 2026 NCT04116502
● Recruiting Phase III Oncology
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator’s Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
What is being tested: Nemtabrutinib (MK-1026), a novel Bruton's tyrosine kinase (BTK) inhibitor, is being directly compared against standard-of-care BTK inhibitors (ibrutinib or acalabrutinib)…
28 Apr 2026 NCT06136559
● Recruiting Phase III Gastroenterology
Extension Study for the Port Delivery System With Ranibizumab (Portal)
Portal Extension Study Summary Implanted drug delivery system releasing ranibizumab shows sustained safety and effectiveness in wet age-related macular degeneration over extended follow-up.
27 Apr 2026 NCT03683251
● Recruiting Phase II / Phase III
A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation
Frexalimab injections compared to tacrolimus tablets in first kidney transplant patients over five years to assess effectiveness and safety.
27 Apr 2026 NCT07412470