- Oral N-acetylcysteine for Retinitis Pigmentosa — Active Not Recruiting • Phase III • NCT05537220.
- NAC supplement may slow vision loss in retinitis pigmentosa by reducing oxidative stress; ongoing trials testing long-term effectiveness.
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Retinitis pigmentosa (RP) is an inherited retinal degeneration caused by one of several mistakes in the genetic code. Such mistakes are called mutations. The mutations cause degeneration of rod photoreceptors which are responsible for vision in dim illumination resulting in night blindness. After rod photoreceptors are eliminated, gradual degeneration of cone photoreceptors occurs resulting in gradual constriction of side vision that eventually causes tunnel vision. Oxidative stress contributes to cone degeneration. N-acetylcysteine (NAC) reduces oxidative stress and in animal models of RP it slowed cone degeneration. In a phase I…