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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

2236 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

2236 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

● Recruiting Phase III Rheumatology
OLE Study With Filgotinib in JIA
Filgotinib appears safe and effective for long-term use in children with polyarticular or systemic juvenile idiopathic arthritis.
27 Apr 2026 NCT07553182
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease
What is being tested: Roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor already approved for treating anaemia in adult CKD patients, is being investigated…
27 Apr 2026 NCT05970172
● Recruiting Phase III Infectious Disease
A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT
What is being tested: This Phase 3 trial compares two intravenous antiviral treatments—brincidofovir (BCV) and cidofovir (CDV)—for managing adenovirus (AdV) viremia in allogeneic hematopoietic…
27 Apr 2026 NCT07387367
● Recruiting Phase III Oncology
Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer
What is being tested: The trial evaluates whether adding stereotactic radiosurgery (SRS) to standard systemic immunotherapy or targeted therapy improves central nervous system progression-free…
27 Apr 2026 NCT05522660
● Recruiting Phase III Oncology
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
What is being tested: JNJ-90301900 (NBTXR3), a nanoparticle therapy activated by radiotherapy, combined with standard radiation therapy ± cetuximab versus radiation therapy ± cetuximab…
27 Apr 2026 NCT04892173
● Recruiting Phase III Oncology
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
What is being tested: The addition of INCB161734 (a KRAS G12D inhibitor) to standard chemotherapy versus chemotherapy alone in patients with metastatic pancreatic cancer…
27 Apr 2026 NCT07522073
● Recruiting Phase III
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
New anti-inflammatory injection (itepekimab) tested alongside steroid nasal spray for difficult-to-treat nasal polyps over one year.
24 Apr 2026 NCT06834360
● Recruiting Phase III
REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome
ION582 improved seizures, sleep and developmental outcomes in Angelman syndrome patients with UBE3A deletions or mutations.
24 Apr 2026 NCT06914609
active not recruiting Phase II / Phase III
An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)
Diacerein ointment tested for safety and effectiveness in treating generalized epidermolysis bullosa simplex blistering disorder.
24 Apr 2026 NCT06073132
● Recruiting Phase III Gastroenterology
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
What is being tested: Efruxifermin (EFX), an FGF21 analogue, is being evaluated in a randomized controlled trial to assess its efficacy and safety in…
24 Apr 2026 NCT06528314
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Migalastat in Pediatric Subjects (2 to
What is being tested: Migalastat, a pharmacological chaperone, is being evaluated for safety, pharmacokinetics, pharmacodynamics, and efficacy in treating paediatric Fabry disease patients aged…
24 Apr 2026 NCT06904261
● Recruiting Phase III Oncology
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
What is being tested: ARTEMIDE-Lung04 evaluates rilvegostomig (a novel immunotherapy agent) versus pembrolizumab monotherapy as first-line treatment in patients with metastatic non-small cell lung…
24 Apr 2026 NCT06868277
● Recruiting Phase III Oncology
Mocravimod as Adjunctive and Maintenance Treatment in AML Patients Undergoing Allo-HCT
What is being tested: Mocravimod, a TLR7 agonist, is being evaluated as an adjunctive and maintenance therapy in acute myeloid leukaemia (AML) patients undergoing…
24 Apr 2026 NCT05429632
● Recruiting Phase III Oncology
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
What is being tested: Long-term safety and efficacy of pembrolizumab (an anti-PD-1 immunotherapy) in patients with advanced tumors who are continuing treatment or follow-up…
24 Apr 2026 NCT03486873
● Recruiting Phase II / Phase III
A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)
A trial testing whether an oral cholesterol-lowering drug is safe and effective in children and teenagers with familial high cholesterol.
23 Apr 2026 NCT07058077
active not recruiting Phase III Oncology
A Global Study to Assess the Effects of Osimertinib in Participants With EGFRm Stage IA2-IA3 NSCLC Following Complete Tumour Resection
Osimertinib after surgery improves survival in early-stage lung cancer patients with specific EGFR mutations.
23 Apr 2026 NCT05120349
active not recruiting Phase II / Phase III
A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)
Mitapivat tested in sickle cell patients to increase haemoglobin levels and reduce painful crisis episodes compared to placebo.
23 Apr 2026 NCT05031780
● Recruiting Phase III Gastroenterology
A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis
Trial testing a new drug (Afimkibart) for treating moderate-to-severe ulcerative colitis in children, measuring safety and effectiveness.
23 Apr 2026 NCT07158242
● Recruiting Phase III Respiratory / COPD / Asthma
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
What is being tested: Depemokimab, a monoclonal antibody, is being evaluated for its effects on airway structure and function in asthma patients using imaging…
23 Apr 2026 NCT06979323
● Recruiting Phase III Oncology
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
Treatment being tested: Sonrotoclax (a BCL2 inhibitor) combined with zanubrutinib (a BTK inhibitor) versus placebo plus zanubrutinib alone in adults with relapsed/refractory mantle cell…
23 Apr 2026 NCT06742996
● Recruiting Phase III Oncology
Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)
What is being tested: Sacituzumab tirumotecan (an antibody-drug conjugate targeting Trop-2) compared against standard chemotherapy (docetaxel or pemetrexed) in previously-treated advanced/metastatic nonsquamous NSCLC patients…
23 Apr 2026 NCT06074588
● Recruiting Phase III Oncology
A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC
Treatment being tested: Durvalumab combined with domvanalimab (a novel anti-CTLA-4 immune checkpoint inhibitor) versus durvalumab alone, given after concurrent chemoradiation in patients with unresectable…
23 Apr 2026 NCT05211895
active not recruiting Phase III
Efficacy and Safety in Imlifidase Desensitized Kidney Tx Patients, Including Two Non-Comparative Reference Cohorts
Imlifidase allows highly sensitized kidney transplant patients with positive crossmatch to receive transplants safely, with good one-year graft survival.
22 Apr 2026 NCT05369975
● Recruiting Phase III Mental Health / Psychiatry
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
New psilocin-based drug CYB003 tested against placebo for treating depression as an add-on therapy.
22 Apr 2026 NCT06793397
active not recruiting Phase III
Study of Ianalumab Versus Placebo in Addition to First-line Corticosteroids in Primary Immune Thrombocytopenia (ITP)
Ianalumab added to steroids didn't improve platelet counts better than steroids alone in newly diagnosed ITP patients.
22 Apr 2026 NCT05653349
● Recruiting Phase III Oncology
A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC)
Drug being tested: GSK5764227 (Risvutatug rezetecan/Ris-Rez) is a novel B7-H3-targeted therapy designed to inhibit cancer cell growth and metastasis in patients with relapsed small…
22 Apr 2026 NCT07099898
● Recruiting Phase III Cardiology / Cardiovascular
Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial – Part 2
What is being tested: Recombinant Factor VIIa (rFVIIa) as a potential therapeutic intervention to halt hematoma expansion and improve outcomes in patients with acute…
22 Apr 2026 NCT07227246
● Recruiting Phase III Cardiology / Cardiovascular
STOP-HAE: A Phase 3 Study of ADX-324 in HAE
What is being tested: ADX-324, a novel therapeutic agent, is being evaluated in a Phase 3 trial to assess its efficacy and safety in…
22 Apr 2026 NCT06960213
● Recruiting Phase III Oncology
A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
What is being tested: BGB-16673, a novel BTK inhibitor, is being evaluated against pirtobrutinib (an established BTK inhibitor) in patients with relapsed/refractory CLL or…
22 Apr 2026 NCT06973187
● Recruiting Phase III Oncology
A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)
What is being tested: This Phase 3 trial compares belantamab mafodotin combined with lenalidomide and dexamethasone (BRd) against daratumumab combined with lenalidomide and dexamethasone…
22 Apr 2026 NCT06679101
● Recruiting Phase III Oncology
Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis
Treatment being tested: IMVT-1402, a novel therapeutic agent, is being evaluated for efficacy, safety and tolerability in adults with generalized myasthenia gravis across mild…
22 Apr 2026 NCT07039916
● Recruiting Phase III Oncology
A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
What is being tested: Zanubrutinib (a Bruton tyrosine kinase inhibitor) combined with obinutuzumab (anti-CD20 monoclonal antibody) versus the standard regimen of lenalidomide plus rituximab…
22 Apr 2026 NCT05100862
● Recruiting Phase III Oncology
Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)
What is being tested: A novel oral cladribine formulation is being evaluated against placebo for efficacy and safety in treating generalized myasthenia gravis (gMG),…
22 Apr 2026 NCT06463587
● Recruiting Phase III Oncology
A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR – HN1)
Treatment being tested: Petosemtamab (a fibroblast activation protein inhibitor) combined with pembrolizumab compared to pembrolizumab monotherapy as first-line treatment for recurrent or metastatic head…
22 Apr 2026 NCT06525220
● Recruiting Phase III
A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)
A new drug (claseprubart) tested against placebo in adults with chronic inflammatory demyelinating polyneuropathy to assess whether it works and is safe.
21 Apr 2026 NCT06858579
active not recruiting Phase III
Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis
ALXN1720 (a complement inhibitor) was tested for safety and effectiveness in treating autoimmune myasthenia gravis in adults.
21 Apr 2026 NCT05556096
● Recruiting Phase III
A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)
Anifrolumab injection added to standard treatment improved muscle disease activity in adults with polymyositis and dermatomyositis compared to placebo.
21 Apr 2026 NCT06455449
active not recruiting Phase III Oncology
A Study to Compare ABP 234 and Keytruda® (Pembrolizumab) in Participants With Advanced or Metastatic Non-squamous Non-Small Cell Lung Cancer
Trial comparing a biosimilar copy of Keytruda with the original drug in advanced lung cancer patients to confirm equivalent effectiveness.
21 Apr 2026 NCT06311721
active not recruiting Phase III Gastroenterology
A Study of Guselkumab in Participants With Fistulizing, Perianal Crohn’s Disease
Guselkumab (IL-23 inhibitor) tested for treating perianal fistulas in Crohn's disease patients, measuring effectiveness and safety.
21 Apr 2026 NCT05347095
● Recruiting Phase III Oncology
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
Treatment being tested: Saruparib (AZD5305), a PARP inhibitor, combined with standard radiotherapy and androgen deprivation therapy versus placebo in men with high-risk and very…
21 Apr 2026 NCT06952803
● Recruiting Phase III Neurology
A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer’s Disease (ADEPT-5)
Treatment being tested: KarXT + KarX-EC combination therapy, a novel muscarinic M1/M4 receptor agonist approach, being evaluated specifically for psychosis symptoms in Alzheimer's disease…
21 Apr 2026 NCT06947941
● Recruiting Phase III Respiratory / COPD / Asthma
Randomised Evaluation of COVID-19 Therapy
What is being tested: RECOVERY is evaluating multiple therapeutic interventions (antivirals, immunomodulators, corticosteroids, and other agents) in hospitalised pneumonia patients, with the primary aim…
21 Apr 2026 NCT04381936
● Recruiting Phase III Oncology
AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL
What is being tested: The trial compares R-mini-CHOP chemotherapy (2 cycles) followed by AZD0486 versus standard R-mini-CHOP (6 cycles) as first-line treatment for large…
21 Apr 2026 NCT07215585
● Recruiting Phase III Oncology
SUPRAME-ACTengine® IMA203 vs. Investigator’s Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
Treatment Being Tested: IMA203, a novel immunotherapy agent, is being compared against investigator's choice of standard treatments (such as checkpoint inhibitors or chemotherapy) in…
21 Apr 2026 NCT06743126
active not recruiting Phase III Cardiology / Cardiovascular
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) – ACCLAIM-Lp(a)
Lepodisiran injection reduces heart attacks and strokes in patients with high lipoprotein(a) levels and existing heart disease.
20 Apr 2026 NCT06292013
● Recruiting Phase III Oncology
A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).
What is being tested: PF-06821497 (mevrometostat), a novel investigational medicine, combined with enzalutamide versus standard treatments (enzalutamide alone or docetaxel chemotherapy) in men with…
20 Apr 2026 NCT06551324
● Recruiting Phase III Oncology
Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)
What is being tested: Capivasertib (AKT inhibitor) combined with CDK4/6 inhibitors and fulvestrant compared to CDK4/6 inhibitors and fulvestrant alone in advanced/metastatic HR+/HER2- breast…
20 Apr 2026 NCT04862663
● Recruiting Phase III Respiratory / COPD / Asthma
Outpatient Treatment With Anti-Coronavirus Immunoglobulin
What is being tested: A single infusion of anti-COVID-19 hyperimmune intravenous immunoglobulin (hIVIG) compared to placebo in recently diagnosed COVID-19 patients, evaluating both safety…
20 Apr 2026 NCT04910269
● Recruiting Phase III Oncology
DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemotherapy
What is being tested: Obrixtamig (a DLL3-targeting agent) combined with atezolizumab, carboplatin, and etoposide versus standard chemotherapy alone in adults with advanced small cell…
20 Apr 2026 NCT07472517
● Recruiting Phase III Oncology
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
What is being tested: Sotorasib (a KRAS G12C inhibitor) combined with platinum doublet chemotherapy versus pembrolizumab (PD-L1 inhibitor) combined with platinum doublet chemotherapy as…
20 Apr 2026 NCT05920356