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Clinical Trial ● Currently Recruiting Phase III NCT06793397

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder — Recruiting • Phase III • Mental Health / Psychiatry • NCT06793397.

📅 22 Apr 2026 ⏱ 1 min read
Currently Recruiting
This trial is actively seeking participants in the UK. Discuss eligibility with your patient before referring.
Status
Currently Recruiting
Phase
Phase III
NCT ID
NCT06793397
Start
2025-12-10
Completion
2027-03-18
ClinicaliQ Trial Snapshot
  • A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder — Recruiting • Phase III • Mental Health / Psychiatry • NCT06793397.
  • New psilocin-based drug CYB003 tested against placebo for treating depression as an add-on therapy.

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What This Trial Is Studying

The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD. Conditions: Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder, Depression Disorders, Depression Disorder, Depression Interventions: CYB003, Psychological Support Lead Sponsor: Cybin IRL Limited Planned Enrollment: 330 participants

Full Trial Details
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Eligibility criteria, protocol, and results when available
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