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Trial Radar

2231 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

2231 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

active not recruiting Phase III Diabetes / Metabolic
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
Weekly semaglutide injections tested against placebo over 5 years to see if it helps fatty liver disease.
17 Apr 2026 NCT04822181
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
What is being tested: Finerenone (a non-steroidal mineralocorticoid receptor antagonist) efficacy, safety, and pharmacokinetics in children with heart failure and left ventricular systolic dysfunction,…
17 Apr 2026 NCT07188805
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria
Treatment being tested: Finerenone (a non-steroidal mineralocorticoid receptor antagonist) in combination with ACE inhibitors or angiotensin receptor blockers in children with chronic kidney disease…
17 Apr 2026 NCT05196035
● Recruiting Phase III Cardiology / Cardiovascular
Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease
What is being tested: Orforglipron, a once-daily treatment, is being evaluated for its efficacy and safety in managing Fontaine II peripheral arterial disease (symptomatic…
17 Apr 2026 NCT07223593
● Recruiting Phase III Cardiology / Cardiovascular
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
What is being tested: AZD0780, an oral PCSK9 inhibitor, is being evaluated in a Phase III randomized controlled trial to assess its efficacy in…
17 Apr 2026 NCT07000357
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)
What is being tested: Orforglipron (LY3502970), a GLP-1 receptor agonist, is being evaluated for its effects on cardiovascular outcomes compared to placebo over approximately…
17 Apr 2026 NCT07241390
● Recruiting Phase III Oncology
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
Intervention being tested: Vepugratinib (LY3866288), a novel therapeutic agent, is being evaluated against placebo in a randomised controlled trial to assess safety, tolerability, and…
17 Apr 2026 NCT07218380
● Recruiting Phase III Oncology
Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia
A new drug combination tested against standard treatment in older adults with newly diagnosed acute lymphoblastic leukaemia.
16 Apr 2026 NCT04994717
active not recruiting Phase III Dermatology
Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant
Elranatamab injections compared to lenalidomide tablets for newly diagnosed myeloma patients after stem cell transplant.
16 Apr 2026 NCT05317416
active not recruiting Phase III
Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)
New drug combination (sonrotoclax plus zanubrutinib) tested against standard treatment (venetoclax plus obinutuzumab) for chronic lymphocytic leukaemia.
16 Apr 2026 NCT06073821
● Recruiting Phase III
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
Researchers tested whether a new migraine drug (BHV-3000) works better than placebo for treating severe migraines in young people.
16 Apr 2026 NCT04649242
● Recruiting Phase III
Phase 3, Open-label, Single-dose Study of CSL222 in Adolescent Male Subjects (≥ 12 to < 18 Years of Age) With Severe or Moderately Severe Hemophilia B
CSL222 Trial Summary CSL222 gene therapy tested in teenage boys with moderate-to-severe hemophilia B for safety, tolerability, and effectiveness.
16 Apr 2026 NCT07080905
active not recruiting Phase III Oncology
A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer
Elinzanetant reduces hot flashes from cancer therapy in breast cancer patients better than placebo.
16 Apr 2026 NCT05587296
active not recruiting Phase III Oncology
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Olaparib
Patients benefiting from olaparib in previous cancer trials can continue receiving it under this extension study.
16 Apr 2026 NCT04421963
● Recruiting Phase III
Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)
What is being tested: Ravulizumab, a complement C5 inhibitor, is being evaluated against placebo for its ability to reduce proteinuria and slow decline in…
16 Apr 2026 NCT06291376
● Recruiting Phase III Respiratory / COPD / Asthma
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn’s Disease (CD)
What is being tested: Long-term safety and efficacy of vedolizumab (an anti-α4β7 integrin monoclonal antibody) as maintenance therapy in paediatric patients with moderate-to-severe ulcerative…
16 Apr 2026 NCT05442567
● Recruiting Phase III Oncology
JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer
What is being tested: A comparison of stereotactic ablative radiotherapy (SAbR) versus surgical sublobar resection (SR) to determine which approach provides superior survival outcomes…
16 Apr 2026 NCT02468024
● Recruiting Phase III Oncology
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)
What is being tested: Elranatamab, a bispecific antibody targeting BCMA and CD3, is being evaluated against standard treatments in relapsed/refractory multiple myeloma (RRMM) patients…
16 Apr 2026 NCT06152575
● Recruiting Phase III Cardiology / Cardiovascular
Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD
What is being tested: Pelacarsen (TQJ230), an antisense oligonucleotide therapy designed to lower lipoprotein(a) (Lp(a)), is being evaluated for efficacy and safety in patients…
16 Apr 2026 NCT06813911
● Recruiting Phase III Oncology
A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)
What is being tested: Sacituzumab tirumotecan (MK-2870), an antibody-drug conjugate, as maintenance therapy either alone or combined with bevacizumab, compared to standard of care…
16 Apr 2026 NCT06824467
● Recruiting Phase III Oncology
Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer
What is being tested: T-DXd (trastuzumab deruxtecan) combined with rilvegostomig or as monotherapy, compared against standard-of-care gemcitabine plus cisplatin with durvalumab in treatment-naïve patients…
16 Apr 2026 NCT06467357
● Recruiting Phase III Oncology
A Study of BGB-16673 Compared to Investigator’s Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors
What is being tested: BGB-16673, a novel therapeutic agent, is being evaluated against standard investigator-selected treatments (idelalisib, bendamustine, or venetoclax—each combined with rituximab) in…
16 Apr 2026 NCT06846671
● Recruiting Phase III Oncology
Study to Evaluate INCB123667 Versus Investigator’s Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
What is being tested: INCB123667, a targeted therapy, is being compared against standard chemotherapy regimens in patients with platinum-resistant ovarian cancer specifically selected for…
16 Apr 2026 NCT07214779
● Recruiting Phase III Oncology
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
What is being tested: Palazestrant (an oral selective oestrogen receptor degrader) combined with ribociclib (CDK4/6 inhibitor) versus the standard treatment of letrozole (aromatase inhibitor)…
16 Apr 2026 NCT07085767
active not recruiting Phase III Oncology
Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer
Ongoing access to darolutamide for prostate cancer patients who benefited from previous trials, with continued monitoring.
15 Apr 2026 NCT04464226
● Recruiting Phase III Neurology
A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)
DEEP SEA Study Summary LP352 tested against placebo to reduce seizures in children and adults with Dravet syndrome over 24 months.
15 Apr 2026 NCT06660394
● Recruiting Phase III Oncology
Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)
Treatment Being Tested: Tarlatamab (a DLL3-targeting bispecific antibody) versus placebo administered after standard chemoradiotherapy in patients with limited-stage small-cell lung cancer, with primary efficacy…
15 Apr 2026 NCT06117774
● Recruiting Phase III Oncology
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
What is being tested: Sonrotoclax (a novel BCL2 inhibitor) combined with monoclonal antibodies (obinutuzumab or rituximab) versus the established standard treatment venetoclax plus rituximab…
15 Apr 2026 NCT06943872
● Recruiting Phase III Respiratory / COPD / Asthma
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
What is being tested: Tezepelumab, a thymic stromal lymphopoietin (TSLP) inhibitor monoclonal antibody, is being evaluated for efficacy and safety in adult patients with…
14 Apr 2026 NCT06883305
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections
Drug being tested: Mavorixafor, a CXCR4 antagonist, is being evaluated for efficacy, safety and tolerability in patients with chronic neutropenic disorders (both congenital and…
14 Apr 2026 NCT06056297
● Recruiting Phase III Oncology
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
What is being tested: Amivantamab (a bispecific antibody) combined with standard chemotherapy (mFOLFOX6 or FOLFIRI) versus the current standard treatment of cetuximab plus chemotherapy…
14 Apr 2026 NCT06662786
● Recruiting Phase III Oncology
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
What is being tested: Amivantamab (a bispecific antibody targeting EGFR and MET) combined with FOLFIRI chemotherapy, compared to the standard treatment of cetuximab/bevacizumab with…
14 Apr 2026 NCT06750094
● Recruiting Phase III Oncology
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
Treatment being tested: Pasritamig (a novel therapeutic agent) combined with docetaxel chemotherapy versus docetaxel alone in metastatic castration-resistant prostate cancer (mCRPC), with primary endpoint…
14 Apr 2026 NCT07225946
● Recruiting Phase III Oncology
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
What is being tested: Divarasib (a KRAS G12C inhibitor) combined with pembrolizumab (immunotherapy) versus standard chemotherapy (pemetrexed plus carboplatin or cisplatin) combined with pembrolizumab…
14 Apr 2026 NCT06793215
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
What is being tested: Finerenone (a non-steroidal mineralocorticoid receptor antagonist) safety and tolerability in children and young adults aged 1-18 years with chronic kidney…
14 Apr 2026 NCT05457283
● Recruiting Phase III
A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression
What is being tested: Sefaxersen (RO7434656), a novel antisense oligonucleotide therapy designed to reduce kidney disease progression in patients with primary IgA nephropathy who…
14 Apr 2026 NCT05797610
● Recruiting Phase III
Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN
What is being tested: Long-term efficacy, safety and tolerability of iptacopan, a Factor B inhibitor targeting the alternative complement pathway, in patients with C3…
14 Apr 2026 NCT03955445
● Recruiting Phase III Rheumatology
A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
Treatment being tested: Long-term safety and efficacy of guselkumab (an IL-23 inhibitor administered subcutaneously) in pediatric patients with moderately to severely active ulcerative colitis,…
14 Apr 2026 NCT06663332
● Recruiting Phase III Rheumatology
A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis
What is being tested: Oral icotrokinra, a novel therapeutic agent, is being evaluated for its efficacy, safety, and tolerability in treating moderately to severely…
14 Apr 2026 NCT07196748
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE
What is being tested: Milvexian, a Factor XIa inhibitor, is being evaluated as a novel anticoagulant to reduce recurrent ischemic stroke risk compared to…
14 Apr 2026 NCT05702034
● Recruiting Phase III Cardiology / Cardiovascular
Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Intervention being tested: Treprostinil palmitil inhalation powder (TPIP) administered once daily for 24 weeks as a potential treatment for pulmonary hypertension associated with interstitial…
14 Apr 2026 NCT07179380
● Recruiting Phase III Oncology
A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)
What is being tested: BMS-986393 (arlo-cel), a novel therapeutic agent, is being compared against standard treatment regimens in patients with relapsed or refractory multiple…
14 Apr 2026 NCT06615479
● Recruiting Phase III Oncology
ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors
What is being tested: ONC-392 (gotistobart), a next-generation anti-CTLA-4 antibody, is being compared against standard docetaxel chemotherapy in patients with metastatic non-small cell lung…
14 Apr 2026 NCT05671510
● Recruiting Phase III Oncology
Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
What is being tested: Saruparib (a PARP inhibitor) combined with camizestrant (an estrogen receptor degrader) versus standard CDK4/6 inhibitor plus endocrine therapy in patients…
14 Apr 2026 NCT06380751
active not recruiting Phase III
A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma
CAR-T cell therapy cilta-cel compared with standard chemotherapy in patients with relapsed multiple myeloma resistant to lenalidomide.
13 Apr 2026 NCT04181827
● Recruiting Phase III
A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)
Trial testing whether adding bleximenib to venetoclax-azacitidine improves outcomes in newly diagnosed AML with specific genetic mutations.
13 Apr 2026 NCT06852222
active not recruiting Phase III Oncology
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer
Adding niraparib to standard prostate cancer treatment (abiraterone and prednisone) delays cancer progression compared to standard treatment alone.
13 Apr 2026 NCT03748641
● Recruiting Phase II / Phase III
A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).
Aficamten improves symptoms and safety in children with obstructive hypertrophic cardiomyopathy, a serious heart muscle condition.
13 Apr 2026 NCT06412666
● Recruiting Phase III Oncology
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma
Trial testing new drug epcoritamab combined with existing treatments for untreated follicular lymphoma, measuring safety and effectiveness in 1095 patients.
13 Apr 2026 NCT06191744
● Recruiting Phase III Infectious Disease
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
Trial testing a group B streptococcus vaccine in pregnant women and babies to assess safety and immune response.
13 Apr 2026 NCT07160244