ClinicaliQ Trial Snapshot
- A Study of BGB-16673 Compared to Investigator’s Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors — Recruiting • Phase III • Oncology • NCT06846671.
- What is being tested: BGB-16673, a novel therapeutic agent, is being evaluated against standard investigator-selected treatments (idelalisib, bendamustine, or venetoclax—each combined with rituximab) in patients with CLL/SLL who have previously failed both BTK and BCL2 inhibitor therapies.
- Patient eligibility overview: The trial targets heavily pre-treated patients with chronic lymphocytic leukemia or small lymphocytic lymphoma who have exhausted two major drug classes (BTK inhibitors like ibrutinib and BCL2 inhibitors like venetoclax), representing a clinically challenging population with limited options.
Use This Page For
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying
The purpose of this study is to investigate the efficacy and safety of BGB-16673 compared with investigator's choice (idelalisib plus rituximab [for CLL only] or bendamustine plus rituximab or venetoclax plus rituximab retreatment) in participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) previously exposed to both BTK inhibitors (BTKi) and BCL2 inhibitors (BCL2i).
Eligibility Snapshot
- : 1. Confirmed diagnosis of CLL or SLL, requiring treatment, based on 2018 international workshop on chronic lymphocytic leukemia (iwCLL) criteria. 2. Previously received treatment for CLL/SLL with both a BTKi and a BCL2i.
- Participants with SLL must have measurable disease by computer tomography (CT)/magnetic resonance imaging (MRI) 4. Eastern Cooperative Oncology Group (ECOG) score 0, 1, or 2 5. Adequate liver function 6. Adequate blood clotting function
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.