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Clinical Trial Active — Not Recruiting Phase III NCT04822181

Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH) — Active Not Recruiting • Phase III • Diabetes / Metabolic • NCT04822181.

📅 17 Apr 2026 ⏱ 1 min read
Active — Not Recruiting
Check the registry for current status and eligibility criteria.
Status
Active — Not Recruiting
Phase
Phase III
NCT ID
NCT04822181
Start
2021-04-01
Completion
2029-04-25
ClinicaliQ Trial Snapshot
  • Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH) — Active Not Recruiting • Phase III • Diabetes / Metabolic • NCT04822181.
  • Weekly semaglutide injections tested against placebo over 5 years to see if it helps fatty liver disease.

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What This Trial Is Studying

Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries. Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance. Participants will need to inject themselves with medicine under the skin. Participants will need to do this once a week. The study will last for about 5 years. Participants will have up to 21 clinic visits and 9 phone calls with the clinical staff…

Full Trial Details
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Eligibility criteria, protocol, and results when available
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Related Clinical Intelligence

Guidelines, Drug Science, safety briefs and education connected to this trial area.

Guideline
Non-Alcoholic Fatty Liver Disease: Assessment and Management (NICE NG49)
Diabetes / Metabolic · 27 Mar 2026
Use FIB-4 or NAFLD Fibrosis Score in primary care to stratify fibrosis risk in adults with metabolic risk factors (type 2 diabetes,…
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Guideline
Semaglutide for Managing Overweight and Obesity (NICE TA875)
Diabetes / Metabolic · 27 Mar 2026
Initiate semaglutide only in specialist obesity services or via shared care with clear primary-secondary care protocols for adults with BMI ≥30 kg/m²…
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Clinical Brief
Semaglutide (Wegovy, Ozempic and Rybelsus): risk of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
Diabetes / Metabolic · MHRA · 05 Feb 2026
Semaglutide (Wegovy, Ozempic and Rybelsus): risk of Non-arteritic Anterior Ische...
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Podcast
GLP-1 Agonists: Semaglutide, Tirzepatide and the Cardiovascular Revolution
Diabetes / Metabolic · 00:15:32 · 03 Apr 2026
GLP-1 receptor agonists mimic gut-derived GLP-1: they increase glucose-dependent insulin release, suppress glucagon and slow gastric emptying. Semaglutide is a once-weekly GLP-1…
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Clinical Brief
UK healthy life expectancy falls by two years in past decade
Diabetes / Metabolic · BBC Health · 27 Apr 2026
UK healthy life expectancy has declined by two years over the past decade, representing a significant reversal in population health trends that…
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Clinical Brief
Rybelsus ® (semaglutide tablets): transition to new formulation and risk of medication error
Diabetes / Metabolic · MHRA · 17 Dec 2025
Rybelsus ® (semaglutide tablets): transition to new formulation and risk of med...
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