Oncology Cardiology / Cardiovascular Respiratory / COPD / Asthma Infectious Disease Gastroenterology Neurology Rheumatology Diabetes / Metabolic Mental Health / Psychiatry Women's Health Dermatology Men's Health Rare Diseases
Clinical Trial Active — Not Recruiting Phase III NCT05757869

A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation

A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation — Active Not Recruiting • Phase III • Cardiology / Cardiovascular • NCT05757869.

📅 08 May 2026 ⏱ 1 min read
Active — Not Recruiting
Check the registry for current status and eligibility criteria.
Status
Active — Not Recruiting
Phase
Phase III
NCT ID
NCT05757869
Start
2023-04-11
Completion
2026-10-31
ClinicaliQ Trial Snapshot
  • A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation — Active Not Recruiting • Phase III • Cardiology / Cardiovascular • NCT05757869.
  • Milvexian tested against apixaban for preventing stroke and blood clots in atrial fibrillation patients.

Verify eligibility, endpoints and current status on the original ClinicalTrials.gov registry before acting on this summary.

Use This Page For
  • Quick orientation before opening the registry record.
  • Checking recruitment status, phase and sponsor at a glance.
  • Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying

The purpose of this study is to evaluate if milvexian is at least as effective as apixaban for reducing the risk of the composite stroke and non-central nervous system (CNS) systemic embolism. Conditions: Atrial Fibrillation Interventions: Milvexian, Apixaban, Placebo, Apixaban Placebo Lead Sponsor: Janssen Research & Development, LLC Planned Enrollment: 20284 participants

Full Trial Details
View this trial on the source registry
Eligibility criteria, protocol, and results when available
View Trial ↗
Share: Twitter/X LinkedIn
Related

Related Clinical Intelligence

Guidelines, Drug Science, safety briefs and education connected to this trial area.

Guideline
2024 ESC Guidelines for the Management of Atrial Fibrillation
Cardiology / Cardiovascular · 30 Mar 2026
Covers AF classification, stroke risk assessment (CHA2DS2-VASc), and bleeding risk (HAS-BLED) • Provides recommendations for rate vs rhythm control strategies • Addresses…
View guideline →
Guideline
Atrial Fibrillation: Diagnosis and Management (NICE NG196)
Cardiology / Cardiovascular · 25 Mar 2026
Use CHA2DS2-VASc score to stratify stroke risk and offer anticoagulation to men scoring ≥2 and women scoring ≥3 (consider treatment at scores…
View guideline →
Clinical Brief
Bird flu vaccine trial against potential pandemic strain begins
Cardiology / Cardiovascular · BBC Health · 21 Apr 2026
H5N1 vaccine trial has commenced targeting a potential pandemic strain currently circulating in bird populations without documented human-to-human transmission The preventive vaccine…
View brief →
Guideline
Stroke and TIA: Diagnosis and Initial Management (NICE NG128)
Cardiology / Cardiovascular · 27 Mar 2026
Use FAST recognition (Face, Arms, Speech, Time) in primary care to identify suspected stroke and arrange immediate hospital admission as a medical…
View guideline →
Clinical Brief
Bromocriptine: monitor blood pressure when prescribing bromocriptine for prevention or inhibition of post-partum physiological lactation
Cardiology / Cardiovascular · MHRA · 24 Oct 2024
A safety review has been conducted by the MHRA following a Yellow Card report concerning a patient who was taking bromocriptine. The…
View brief →
Guideline
Semaglutide for reducing the risk of major adverse cardiovascular events in people with cardiovascular disease and overweight or obesity
Cardiology / Cardiovascular · 07 May 2026
Semaglutide is recommended for adults with established cardiovascular disease and overweight/obesity to reduce major adverse cardiovascular events – consider prescribing as part…
View guideline →