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Trial Radar

1003 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

active not recruiting Phase III
Oral N-acetylcysteine for Retinitis Pigmentosa
NAC supplement may slow vision loss in retinitis pigmentosa by reducing oxidative stress; ongoing trials testing long-term effectiveness.
04 May 2026 NCT05537220
● Recruiting Phase III
A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease
Rilzabrutinib reduces disease flares and controls IgG4-related disease activity better than placebo over 52 weeks in adults.
04 May 2026 NCT07190196
● Recruiting Phase III Respiratory / COPD / Asthma
A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
What is being tested: The efficacy and safety of axatilimab (a CD40 ligand antagonist) combined with corticosteroids versus placebo plus corticosteroids as first-line treatment…
04 May 2026 NCT06585774
● Recruiting Phase III Oncology
Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation
What is being tested: Revumenib, a menin inhibitor, combined with intensive chemotherapy versus chemotherapy alone in newly diagnosed AML patients with NPM1 mutations, evaluating…
04 May 2026 NCT07211958
● Recruiting Phase III Rheumatology
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
Dapirolizumab pegol added to standard treatment improves moderate to severe lupus disease activity.
01 May 2026 NCT06617325
active not recruiting Phase III Oncology
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)
Adding pembrolizumab immunotherapy to chemoradiotherapy improves survival and delays cancer progression in muscle-invasive bladder cancer patients avoiding surgery.
01 May 2026 NCT04241185
active not recruiting Phase III Gastroenterology
Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)
Elafibranor tested against placebo in PBC patients inadequately responding to ursodeoxycholic acid, assessing alkaline phosphatase reduction and safety.
01 May 2026 NCT04526665
active not recruiting Phase III Oncology
Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
Two immunotherapy drugs versus standard chemotherapy for advanced lung cancer without specific genetic mutations.
01 May 2026 NCT02542293
active not recruiting Phase III Neurology
A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
Long-term safety and efficacy study of ocrelizumab, a B-cell depleting antibody, in multiple sclerosis patients continuing from previous trials.
01 May 2026 NCT05269004
active not recruiting Phase III Mental Health / Psychiatry
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Panorama)
MM120 was tested against placebo for anxiety disorder in a large, rigorous trial with long-term follow-up.
01 May 2026 NCT06809595
active not recruiting Phase III Gastroenterology
A Study of Elafibranor in Adults With Primary Biliary Cholangitis and Inadequate Response or Intolerance to Ursodeoxycholic Acid.
Trial testing elafibranor versus placebo in primary biliary cholangitis patients who cannot tolerate or inadequately respond to ursodeoxycholic acid, measuring effects on alkaline phosphatase…
30 Apr 2026 NCT06383403
active not recruiting Phase III
A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment
Two new PNH drugs (pozelimab + cemdisiran) tested for safety and effectiveness against existing complement inhibitor treatments.
30 Apr 2026 NCT05133531
● Recruiting Phase III Oncology
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician’s Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Treatment being tested: Sacituzumab govitecan-hziy (an antibody-drug conjugate targeting Trop-2) combined with pembrolizumab (PD-L1 inhibitor) versus physician's choice treatment in the adjuvant setting following…
30 Apr 2026 NCT05633654
● Recruiting Phase III Oncology
Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen
What is being tested: Paltusotine, an oral daily medication, is being evaluated against placebo in a Phase 3 randomized controlled trial to assess its…
30 Apr 2026 NCT07087054
● Recruiting Phase III Oncology
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
Treatment Being Tested: Ivonescimab (a dual TIGIT/PD-L1 pathway inhibitor) combined with chemotherapy compared to pembrolizumab (PD-L1 inhibitor) combined with chemotherapy as first-line therapy for…
30 Apr 2026 NCT05899608
● Recruiting Phase III Cardiology / Cardiovascular
Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)
Treatment being tested: ADX-324 is a novel therapy being evaluated for long-term safety and efficacy in hereditary angioedema (HAE) Types I and II, building…
30 Apr 2026 NCT07428499
● Recruiting Phase III Oncology
A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)
What is being tested: AZD0120, a dual-targeted CAR-T cell therapy targeting both BCMA and CD19 antigens, is being compared against standard chemotherapy regimens (daratumumab-based…
30 Apr 2026 NCT07391657
● Recruiting Phase III Oncology
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
What is being tested: Quizartinib (a FLT3 inhibitor) plus standard chemotherapy versus placebo plus chemotherapy in newly diagnosed FLT3-ITD negative AML patients to determine…
30 Apr 2026 NCT06578247
● Recruiting Phase III Oncology
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
What is being tested: A randomised comparison of two triple-drug regimens—mezigdomide (a novel cereblon modulator) combined with bortezomib and dexamethasone versus the established pomalidomide…
30 Apr 2026 NCT05519085
active not recruiting Phase III
A Randomized, Double-blind 2-arm, Followed by an Open-label 1-arm, NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.
Long-term safety and effectiveness study of ianalumab, a new drug treatment for patients with Sjögren's syndrome.
29 Apr 2026 NCT05985915
● Recruiting Phase III
Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN
Iptacopan reduces kidney damage better than placebo in patients with a specific type of glomerulonephritis.
29 Apr 2026 NCT05755386
● Recruiting Phase III
A Study to Assess the Efficacy and Safety of Efgartigimod IV in Adult Participants With Primary Immune Thrombocytopenia
Study testing intravenous efgartigimod versus placebo in adults with immune thrombocytopenia to assess effectiveness and safety.
29 Apr 2026 NCT06544499
● Recruiting Phase III
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
Xeomin injections tested against placebo for reducing monthly migraine days in chronic migraine patients over one year.
29 Apr 2026 NCT07018713
active not recruiting Phase III Neurology
A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.
ZX008 reduced seizures in children and adults with CDKL5 deficiency disorder compared to placebo.
29 Apr 2026 NCT05064878
active not recruiting Phase III Dermatology
A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo
52-week trial testing whether continuing or increasing ritlecitinib dosing maintains or improves skin pigmentation recovery in non-segmental vitiligo patients.
29 Apr 2026 NCT06163326
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
What is being tested: Finerenone (a non-steroidal mineralocorticoid receptor antagonist) versus placebo in hospitalized patients with acute decompensated heart failure, specifically targeting those with…
29 Apr 2026 NCT06008197
● Recruiting Phase III Oncology
Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer
Intervention being tested: Sacituzumab govitecan (an antibody-drug conjugate targeting Trop-2) compared against standard of care chemotherapy in patients with previously treated extensive-stage small cell…
29 Apr 2026 NCT06801834
● Recruiting Phase III Oncology
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
What is being tested: Datopotamab deruxtecan (Dato-DXd), a TROP2-targeted antibody-drug conjugate, is being compared against standard docetaxel chemotherapy in previously treated advanced/metastatic non-squamous NSCLC…
29 Apr 2026 NCT07291037
● Recruiting Phase III
Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation
Ravulizumab drug reduced need for dialysis after kidney transplant compared to placebo in high-risk patients.
28 Apr 2026 NCT06830798
● Recruiting Phase III
A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)
Enlicitide added to rosuvastatin reduced cholesterol more than rosuvastatin alone in high cholesterol patients.
28 Apr 2026 NCT07216482
● Recruiting Phase III Respiratory / COPD / Asthma
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer’s Disease (ADEPT-2)
Treatment being tested: KarXT, a novel muscarinic M1/M4 receptor agonist, is being evaluated for treating psychosis (including hallucinations, delusions, and agitation) in patients with…
28 Apr 2026 NCT06126224
● Recruiting Phase III Oncology
MITHRIDATE: Ruxolitinib Versus Hydroxycarbamide or Interferon as First Line Therapy in High Risk Polycythemia Vera
The trial will be a phase III, randomised-controlled, multi-centre, international, open-label trial consisting of ruxolitinib versus best available therapy, where best available therapy is…
28 Apr 2026 NCT04116502
● Recruiting Phase III Oncology
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator’s Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
The goal of this study is to evaluate nemtabrutinib compared with investigator's choice of ibrutinib or acalabrutinib in participants with chronic lymphocytic leukemia (CLL)/small…
28 Apr 2026 NCT06136559
● Recruiting Phase III Gastroenterology
Extension Study for the Port Delivery System With Ranibizumab (Portal)
Portal Extension Study Summary Implanted drug delivery system releasing ranibizumab shows sustained safety and effectiveness in wet age-related macular degeneration over extended follow-up.
27 Apr 2026 NCT03683251
● Recruiting Phase II / Phase III
A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation
Frexalimab injections compared to tacrolimus tablets in first kidney transplant patients over five years to assess effectiveness and safety.
27 Apr 2026 NCT07412470
● Recruiting Phase III Rheumatology
OLE Study With Filgotinib in JIA
Filgotinib appears safe and effective for long-term use in children with polyarticular or systemic juvenile idiopathic arthritis.
27 Apr 2026 NCT07553182
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease
Roxadustat is a licensed medicine to treat anemia in adults with chronic kidney disease (CKD). Anemia is a low level of red blood cells.…
27 Apr 2026 NCT05970172
● Recruiting Phase III Infectious Disease
A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT
This randomized, open-label, parallel group, two-arm, multi-center assessment will compare IV BCV with IV CDV in adult and pediatric allogeneic HCT recipients with AdV…
27 Apr 2026 NCT07387367
● Recruiting Phase III Oncology
Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer
The primary objective of the study is to assess the efficacy in terms of CNS-specific PFS of the combination of standard systemic treatment plus…
27 Apr 2026 NCT05522660
● Recruiting Phase III Oncology
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
This is a global, open-label, randomized, 2-arm, Investigator's choice Phase 3 (Pivotal Stage) study to investigate the efficacy and safety of JNJ-90301900 (NBTXR3) /…
27 Apr 2026 NCT04892173
● Recruiting Phase III Oncology
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
The purpose of this study is to evaluate the efficacy and safety of standard chemotherapy with or without INCB161734 in participants with metastatic pancreatic…
27 Apr 2026 NCT07522073
● Recruiting Phase III
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
New anti-inflammatory injection (itepekimab) tested alongside steroid nasal spray for difficult-to-treat nasal polyps over one year.
24 Apr 2026 NCT06834360
● Recruiting Phase III
REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome
ION582 improved seizures, sleep and developmental outcomes in Angelman syndrome patients with UBE3A deletions or mutations.
24 Apr 2026 NCT06914609
active not recruiting Phase II / Phase III
An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)
Diacerein ointment tested for safety and effectiveness in treating generalized epidermolysis bullosa simplex blistering disorder.
24 Apr 2026 NCT06073132
● Recruiting Phase III Gastroenterology
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
What is being tested: Efruxifermin (EFX), an FGF21 analogue, is being evaluated in a randomized controlled trial to assess its efficacy and safety in…
24 Apr 2026 NCT06528314
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Migalastat in Pediatric Subjects (2 to
What is being tested: Migalastat, a pharmacological chaperone, is being evaluated for safety, pharmacokinetics, pharmacodynamics, and efficacy in treating paediatric Fabry disease patients aged…
24 Apr 2026 NCT06904261
● Recruiting Phase III Oncology
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
What is being tested: ARTEMIDE-Lung04 evaluates rilvegostomig (a novel immunotherapy agent) versus pembrolizumab monotherapy as first-line treatment in patients with metastatic non-small cell lung…
24 Apr 2026 NCT06868277
● Recruiting Phase III Oncology
Mocravimod as Adjunctive and Maintenance Treatment in AML Patients Undergoing Allo-HCT
What is being tested: Mocravimod, a TLR7 agonist, is being evaluated as an adjunctive and maintenance therapy in acute myeloid leukaemia (AML) patients undergoing…
24 Apr 2026 NCT05429632
● Recruiting Phase III Oncology
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
What is being tested: Long-term safety and efficacy of pembrolizumab (an anti-PD-1 immunotherapy) in patients with advanced tumors who are continuing treatment or follow-up…
24 Apr 2026 NCT03486873
● Recruiting Phase II / Phase III
A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)
A trial testing whether an oral cholesterol-lowering drug is safe and effective in children and teenagers with familial high cholesterol.
23 Apr 2026 NCT07058077