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Clinical Trial ● Currently Recruiting Phase I NCT07036029

NAL ER IPF Respiratory Function and Safety Study

NAL ER IPF Respiratory Function and Safety Study — Recruiting • Phase I • Respiratory / COPD / Asthma • NCT07036029.

📅 10 Apr 2026 ⏱ 1 min read
Currently Recruiting
This trial is actively seeking participants in the UK. Discuss eligibility with your patient before referring.
Status
Currently Recruiting
Phase
Phase I
NCT ID
NCT07036029
Sponsor
Trevi Therapeutics
Start
2025-08-21
ClinicaliQ Trial Snapshot
  • NAL ER IPF Respiratory Function and Safety Study — Recruiting • Phase I • Respiratory / COPD / Asthma • NCT07036029.
  • What is being tested: Escalating doses of NAL ER (N-acetylcysteine extended-release) to evaluate its safety, tolerability, and effects on respiratory function in idiopathic pulmonary fibrosis (IPF) patients.
  • Patient eligibility overview: The trial enrolls participants with diagnosed IPF who meet specific safety and respiratory function criteria, allowing assessment of the drug's effects across the target disease population.
Use This Page For
  • Quick orientation before opening the registry record.
  • Checking recruitment status, phase and sponsor at a glance.
  • Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying

The primary purpose of this study is to assess the safety and tolerability of escalating doses of NAL ER and to evaluate its effect on respiratory function in participants with IPF.

Eligibility Snapshot
  • : * Diagnosis of IPF as determined by a pulmonologist based on American Thoracic Society (ATS)/ European Respiratory Society (ERS) / Japanese Respiratory Society (JRS) / Asociación Latinoamericana de Tórax (ALAT) guidelines. * SpO2 ≥ 92%, taken after at least 5 minutes in a sitting position, undisturbed and non-stimulated - Saturation of Hemoglobin with Oxygen as measured by pulse oximetry. * FVC ≥ 40% of Global Lung Function Initiative (GLI) 2012 predicted values- Forced Vital Capacity, as determined by spirometry adhering to ATS/ERS guidelines.

Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.

Full Trial Details
View this trial on the source registry
Eligibility criteria, protocol, and results when available
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Related

Related Clinical Intelligence

Guidelines, Drug Science, safety briefs and education connected to this trial area.

Guideline
Idiopathic Pulmonary Fibrosis: Diagnosis and Management (NICE NG163)
Respiratory / COPD / Asthma · 27 Mar 2026
Suspect IPF in adults aged >50 presenting with unexplained progressive dyspnoea, cough, or fatigue with significant smoking history or occupational exposure, and…
View guideline →
Guideline
2022 ERS Guidelines on Idiopathic Pulmonary Fibrosis
Respiratory / COPD / Asthma · 30 Mar 2026
Covers diagnostic criteria for idiopathic pulmonary fibrosis (IPF) including HRCT patterns • Provides recommendations for antifibrotic therapy and patient selection • Addresses…
View guideline →
Clinical Brief
Could sleep app data help identify respiratory disease trends in England?
Respiratory / COPD / Asthma · UKHSA · 28 Jan 2026
UKHSA and Sleep Cycle are collaborating to analyse app-generated cough and sleep data to identify respiratory disease trends earlier across England's population…
View brief →
Guideline
Digital technologies for applying algorithms to spirometry to support asthma and COPD diagnosis in primary care and community diagnostic centres: early-use assessment
Respiratory / COPD / Asthma · 02 Apr 2026
Digital spirometry algorithms can improve diagnostic accuracy for asthma and COPD in primary care and community diagnostic centres, potentially reducing unnecessary referrals…
View guideline →
Guideline
Digital technologies to support self-management of asthma: early-use assessment
Respiratory / COPD / Asthma · 05 May 2026
Use digital asthma self-management tools (apps, web platforms, wearables) as adjuncts to standard care to help patients monitor symptoms, track triggers, and…
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CPD
NICE NG185: COVID-19 Rapid Guideline — Long-term Effects
Infectious Disease · 1.0 CPD hour · 25 Mar 2026
Distinguish ongoing symptomatic COVID-19 from post-COVID-19 syndrome using NICE NG185 definitions. Structure a holistic long COVID assessment across physical, cognitive, psychological and…
Complete CPD →