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Clinical Trial Active — Not Recruiting Phase III NCT04432584

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors — Active Not Recruiting…

📅 26 Oct 2026 ⏱ 1 min read
Active — Not Recruiting
Check the registry for current status and eligibility criteria.
Status
Active — Not Recruiting
Phase
Phase III
NCT ID
NCT04432584
Start
2020-09-30
Completion
2027-04-18
ClinicaliQ Trial Snapshot
  • A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors — Active Not Recruiting • Phase III • NCT04432584.
  • Crovalimab was as safe and effective as eculizumab in treating PNH patients already on complement inhibitor therapy.

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What This Trial Is Studying

A study designed to evaluate the safety of crovalimab with eculizumab in participants with PNH currently treated with complement inhibitors. This study will enroll approximately 190 participants. Conditions: Paroxysmal Nocturnal Hemoglobinuria Interventions: Crovalimab, Eculizumab Lead Sponsor: Hoffmann-La Roche Planned Enrollment: 190 participants

Full Trial Details
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Eligibility criteria, protocol, and results when available
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