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Clinical Trial ● Currently Recruiting Phase I / Phase II NCT06842186

A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity

A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity — Recruiting • Phase I / Phase II • Diabetes / Metabolic • NCT06842186.

📅 26 Oct 2026 ⏱ 1 min read
Currently Recruiting
This trial is actively seeking participants in the UK. Discuss eligibility with your patient before referring.
Status
Currently Recruiting
Phase
Phase I / Phase II
NCT ID
NCT06842186
Start
2025-01-31
Completion
2027-12
ClinicaliQ Trial Snapshot
  • A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity — Recruiting • Phase I / Phase II • Diabetes / Metabolic • NCT06842186.
  • WVE-007 is a new injectable weight-loss drug being tested for safety and effectiveness in overweight and obese adults, with and without type 2 diabetes.

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What This Trial Is Studying

The purpose of this study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of ascending doses of WVE-007 when administered subcutaneously (SC) . Part A is a single ascending dose study in adults living with overweight and obesity. The Part B of the study is a repeat dose administration in adult with obesity, with or without Type 2 Diabetes (T2D and non-T2D, respectively). In addition, Part B includes two dose groups that will receive WVE-007 and tirzepatide in adults living with obesity and T2D. Conditions: Overweight and Obesity Interventions:…

Full Trial Details
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Eligibility criteria, protocol, and results when available
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Related Clinical Intelligence

Guidelines, Drug Science, safety briefs and education connected to this trial area.

Guideline
Semaglutide for Managing Overweight and Obesity (NICE TA875)
Diabetes / Metabolic · 27 Mar 2026
Initiate semaglutide only in specialist obesity services or via shared care with clear primary-secondary care protocols for adults with BMI ≥30 kg/m²…
View guideline →
Guideline
Tirzepatide for Managing Overweight and Obesity (NICE TA1026)
Diabetes / Metabolic · 27 Mar 2026
Prescribe tirzepatide to adults with BMI ≥35 kg/m² or BMI 30–34.9 kg/m² with weight-related comorbidities, initiating treatment in specialist weight management services…
View guideline →
Clinical Brief
New drug to stop ‘Ozempic butt’ muscle loss side effect of obesity jabs
Diabetes / Metabolic · BBC Health · 08 Jun 2026
Weight loss from GLP-1 receptor agonists results in approximately 33% muscle loss alongside fat loss, necessitating clinical attention to body composition changes…
View brief →
Clinical Brief
New light shed on who benefits most from weight-loss jabs
Diabetes / Metabolic · BBC Health · 08 Apr 2026
People who carry variations in two genes linked to appetite and digestion can lose more weight when taking drugs to treat obesity,…
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Guideline
Teplizumab for delaying the onset of stage 3 type 1 diabetes in people 8 years and over with stage 2 type 1 diabetes
Diabetes / Metabolic · 09 Jul 2026
Teplizumab is recommended for people aged 8 years and over with stage 2 type 1 diabetes to delay progression to stage 3;…
View guideline →
Guideline
Non-Alcoholic Fatty Liver Disease: Assessment and Management (NICE NG49)
Diabetes / Metabolic · 27 Mar 2026
Use FIB-4 or NAFLD Fibrosis Score in primary care to stratify fibrosis risk in adults with metabolic risk factors (type 2 diabetes,…
View guideline →