Clinical News

⚠️ Safety Alert

MHRA 23 Sep 2025

Paracetamol and pregnancy – reminder that taking paracetamol during pregnancy remains safe

Patients should be reminded and reassured that there is no evidence that taking paracetamol during pregnancy causes autism in children.…

⚠️ Safety Alert

MHRA 07 Jul 2025

Abrysvo▼ (Pfizer RSV vaccine) and Arexvy▼ (GSK RSV vaccine): be alert to a small risk of Guillain-Barré syndrome following vaccination in older adults

There is a small increase in the risk of Guillain-Barré syndrome following vaccination with Abrysvo (Pfizer respiratory syncytial virus (RSV)…

⚠️ Safety Alert

MHRA 24 Apr 2025

Short-acting beta 2 agonists (SABA) (salbutamol and terbutaline): reminder of the risks from overuse in asthma and to be aware of changes in the SABA prescribing guidelines

Healthcare professionals and patients are reminded of the risk of severe asthma attacks and increased mortality associated with overuse of…

⚠️ Safety Alert

MHRA 28 Jan 2025

GLP-1 and dual GIP/GLP-1 receptor agonists: potential risk of pulmonary aspiration during general anaesthesia or deep sedation

Healthcare professionals should be aware of the potential risk of pulmonary aspiration in patients using GLP-1 or dual GIP/GLP-1 receptor…

⚠️ Safety Alert

MHRA 05 Sep 2024

Valproate use in men: as a precaution, men and their partners should use effective contraception

A retrospective observational study has indicated a possible association between valproate use by men around the time of conception and…

⚠️ Safety Alert

MHRA 20 Jun 2024

Topiramate (Topamax): introduction of new safety measures, including a Pregnancy Prevention Programme

Topiramate is now contraindicated in pregnancy and in women of childbearing potential unless the conditions of a Pregnancy Prevention Programme…

⚠️ Safety Alert

MHRA 29 Apr 2024

Montelukast: reminder of the risk of neuropsychiatric reactions

Healthcare professionals prescribing montelukast should be alert to the risk of neuropsychiatric reactions in all patients including children and adolescents.…

Paracetamol and pregnancy – reminder that taking paracetamol during pregnancy remains safe

Abrysvo▼ (Pfizer RSV vaccine) and Arexvy▼ (GSK RSV vaccine): be alert to a small risk of Guillain-Barré syndrome following vaccination in older adults

Short-acting beta 2 agonists (SABA) (salbutamol and terbutaline): reminder of the risks from overuse in asthma and to be aware of changes in the SABA prescribing guidelines

GLP-1 and dual GIP/GLP-1 receptor agonists: potential risk of pulmonary aspiration during general anaesthesia or deep sedation

Valproate use in men: as a precaution, men and their partners should use effective contraception

Topiramate (Topamax): introduction of new safety measures, including a Pregnancy Prevention Programme

Montelukast: reminder of the risk of neuropsychiatric reactions

Join 10,000+ UK Clinicians

GLP-1 and dual GIP/GLP-1 receptor agonists: potential risk of pulmonary aspiration during general anaesthesia or deep sedation