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Clinical Trial Enrolling PHASE1, PHASE2

A Study to Evaluate the Safety and the Activity of S095029 as Part of Combination Therapy in Advanced Gastroesophageal Junction/Gastric Cancers.

This study will investigate the safety, tolerability, and antitumor activity of S095029 (anti-NKG2A antibody) in combination with pembrolizumab in in microsatellite instability-high/Defective mismatch repair (MSI-H/dMMR) locally advanced unresectable or metastatic gastric /GEJ adenocarcinomas. Conditions: MSI-H/dMMR Gastroesophageal-junction Cancer, MSI-H/dMMR Gastric Cancer Interventions: S095029, pembrolizumab 200 mg (KEYTRUDA ®) Lead Sponsor: Servier Bio-Innovation LLC Planned Enrollment: 48 […]

📅 03 Apr 2026 ⏱ 1 min read
Enrolling
Check the registry for current status and eligibility criteria.
Status
Enrolling
Phase
PHASE1, PHASE2
Start
2024-08-31
Completion
2027-08

Key Clinical Points

• Early-stage trial testing a new antibody combined with pembrolizumab for advanced stomach cancer with specific genetic features.

This study will investigate the safety, tolerability, and antitumor activity of S095029 (anti-NKG2A antibody) in combination with pembrolizumab in in microsatellite instability-high/Defective mismatch repair (MSI-H/dMMR) locally advanced unresectable or metastatic gastric /GEJ adenocarcinomas.

Conditions: MSI-H/dMMR Gastroesophageal-junction Cancer, MSI-H/dMMR Gastric Cancer

Interventions: S095029, pembrolizumab 200 mg (KEYTRUDA ®)

Lead Sponsor: Servier Bio-Innovation LLC

Planned Enrollment: 48 participants

Full Trial Details
View this trial on the source registry
Eligibility criteria, protocol, and results when available
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