Clinical Trials

recruiting PHASE3 Respiratory / COPD / Asthma NCT07190222

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype

This is a parallel, Phase 2b/Phase 3, 3-arm study to investigate the efficacy, safety, and tolerability of subcutaneous (SC) treatment with lunsekimig compared with placebo in adult participants (aged 40…

Sponsor: Sanofi

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recruiting PHASE2 Respiratory / COPD / Asthma NCT07082738

A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

This Phase IIb dose-ranging study will evaluate the efficacy and safety of 3 different doses of AZD6793 compared with placebo tablets in participants with moderate to very severe chronic obstructive…

Sponsor: AstraZeneca

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recruiting NA Respiratory / COPD / Asthma NCT06035120

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

This is a prospective, open-label, multi-center, single-arm study planned to enroll 200 subjects with heterogeneous emphysema and collateral ventilation (CV) in the target lobe. Subjects will undergo instillation of AeriSeal…

Sponsor: Pulmonx Corporation

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recruiting Respiratory / COPD / Asthma NCT06923774

European Real-World Registry for Use of the Ion Endoluminal System

The objective of this study is to collect collect real-world data for the Ion endoluminal system.

Sponsor: Intuitive Surgical

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recruiting PHASE3 Respiratory / COPD / Asthma NCT07170150

A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer’s Disease

The purpose of this study is to assess the efficacy and safety of trontinemab in participants with early symptomatic Alzheimer's disease (AD) (mild cognitive impairment [MCI] to mild dementia due…

Sponsor: Hoffmann-La Roche

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recruiting Respiratory / COPD / Asthma NCT04477785

PPMI Clinical – Establishing a Deeply Phenotyped PD Cohort

The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson's…

Sponsor: Michael J. Fox Foundation for Parkinson's Research

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recruiting PHASE4 Respiratory / COPD / Asthma NCT06444113

Concentration of Ofatumumab in the Breast Milk of Lactating Women With Relapsing Forms of Multiple Sclerosis

This study will evaluate whether ofatumumab is excreted at quantifiable levels and at which concentrations in breast milk of lactating women with RMS). The study will include lactating mothers who…

Sponsor: Novartis Pharmaceuticals

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recruiting PHASE2 Respiratory / COPD / Asthma NCT04302870

Motor Neurone Disease – Systematic Multi-Arm Adaptive Randomised Trial

MND-SMART is investigating whether selected drugs can slow down the progression of motor neuron disease (MND) and improve survival. The study is 'multi-arm' meaning more than one treatment will be…

Sponsor: University of Edinburgh

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recruiting PHASE3 Respiratory / COPD / Asthma NCT03969329

A Phase 3 Study of Etelcalcetide in Children With Secondary Hyperparathyroidism Receiving Hemodialysis

Assess the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of etelcalcetide in the treatment of secondary hyperparathyroidism (SHPT) in pediatric participants between ≥ 2 to < 18 years of age,…

Sponsor: Amgen

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recruiting Respiratory / COPD / Asthma NCT07419321

Social Isolation and Aging in Schizophrenia

Individuals diagnosed with schizophrenia and related psychotic disorders (SZ) exhibit a markedly elevated risk of premature mortality, with a 10-20-year shorter lifespan relative to the general population. Increased mortality rates…

Sponsor: Icahn School of Medicine at Mount Sinai

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