Infectious Disease
Infectious disease guidance, antimicrobial updates, safety signals and trial intelligence for clinicians managing changing pathogens, resistance and immunisation evidence.
Latest Guidelines
Transvenous embolisation for spontaneous intracranial hypotension caused by a cerebrospinal fluid–venous fistula
Consider transvenous embolisation in patients with spontaneous intracranial hypotension confirmed to have a cerebrospinal fluid–venous fistula, as it offers a targeted intervention when conservative management has…
2022 ESCMID Guidelines on Candidaemia and Invasive Candidiasis
This ESCMID guideline addresses 2022 ESCMID Guidelines on Candidaemia and Invasive Candidiasis in Infectious Disease. Use it to review current recommendation wording, eligibility criteria, and implementation…
HIV Testing: Increasing Uptake Among People Who May Have Undiagnosed HIV (NICE PH33)
Offer opt-out HIV testing in emergency departments, sexual health clinics, and antenatal services to maximise identification of undiagnosed HIV cases without requiring explicit patient consent Implement…
COVID-19: Managing the Long-Term Effects (NICE NG188)
Diagnose long COVID when symptoms persist for more than 4 weeks after acute COVID-19 infection and alternative diagnoses have been excluded; undertake baseline assessment including FBC,…
Tuberculosis (NICE NG33)
Offer TB testing to all contacts of patients with active pulmonary or laryngeal TB within two weeks of case notification using IGRA (preferred) or TST to…
Cellulitis and Erysipelas: Antimicrobial Prescribing (NICE NG141)
For non-severe cellulitis in adults, prescribe oral flucloxacillin 500 mg four times daily; use cephalexin 500 mg four times daily if penicillin-allergic • For severe cellulitis…
Trial Radar
Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney Injury (CLEAR-AKI)
TIN816 drug tested at three doses in critically ill patients with kidney injury from sepsis to assess safety…
NAFatigue in Lupus Intervention Programmes (FLIP)
Virtual group fatigue management programme may reduce fatigue impact in lupus patients better than booklet alone.
PHASE3Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F/TAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex With Men and Are At Risk of HIV-1 Infection
Daily F/TAF tablet prevents HIV infection in high-risk men and transgender women compared with F/TDF.
PHASE2A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.
What is being tested: AZD4144, an investigational drug being evaluated for its efficacy, safety, and tolerability in treating…
Clinical News
New HIV report shows progress but inequalities persist in access to testing, PrEP and early diagnosis
Black African heterosexual women show disproportionately low HIV testing uptake in sexual health services, highlighting a persistent gap…
13 May 2026Patients of retired dentist warned of bloodborne viruses, including HIV
Patients treated by a retired Australian dentist are being advised to undergo testing for bloodborne viruses including HIV…
11 May 2026UK alcohol deaths fall for first time since Covid pandemic
Alcohol-related deaths in the UK have decreased for the first time since the Covid pandemic, representing a modest…
17 Apr 2026Pregnancy vaccine reduces baby hospital admissions for RSV by 80%
Maternal RSV vaccination reduces infant hospitalisation risk by 80%, offering significant protection against severe lower respiratory tract infection…
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