Respiratory / COPD / Asthma
Respiratory guidelines, trial intelligence, inhaled and biologic therapy mechanisms, and education across asthma, COPD and severe respiratory disease.
Latest Guidelines
Brensocatib for treating non-cystic fibrosis bronchiectasis in people 12 years and over (terminated evaluation)
Evaluation terminated: Brensocatib for non-CF bronchiectasis is no longer under NICE appraisal—do not initiate new treatment pathways for this indication pending alternative guidance from your local…
Mepolizumab for maintenance treatment of uncontrolled chronic obstructive pulmonary disease with raised blood eosinophils
Mepolizumab is recommended for patients with uncontrolled COPD and blood eosinophils ≥100 cells/μL; check eosinophil levels before initiating treatment as this is a mandatory eligibility criterion.…
UK Achondroplasia Network’s consensus guideline for multidisciplinary care of children and young people with achondroplasia: NICE review
Establish multidisciplinary team review at diagnosis and at key developmental stages (infancy, pre-school, school age, adolescence) to monitor for complications including spinal stenosis, foramen magnum stenosis,…
Digital technologies to support self-management of asthma: early-use assessment
Use digital asthma self-management tools (apps, web platforms, wearables) as adjuncts to standard care to help patients monitor symptoms, track triggers, and improve medication adherence—particularly beneficial…
Digital technologies for applying algorithms to spirometry to support asthma and COPD diagnosis in primary care and community diagnostic centres: early-use assessment
Digital spirometry algorithms can improve diagnostic accuracy for asthma and COPD in primary care and community diagnostic centres, potentially reducing unnecessary referrals to secondary care and…
GOLD 2025 Report: Global Strategy for Prevention, Diagnosis and Management of COPD
GOLD 2025 updates COPD diagnosis criteria: spirometry FEV1/FVC
Trial Radar
A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer’s Disease
Treatment being tested: Trontinemab, a monoclonal antibody targeting Alzheimer's disease pathology, is being evaluated in cognitively unimpaired individuals…
PHASE2Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD
Treatment Being Tested: Two different oral doses of vapendavir (an investigational antiviral) versus placebo in COPD patients with…
PHASE2Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
What is being tested: BTI-203 evaluates rhu-pGSN (recombinant human plasma gelsolin), an anti-inflammatory agent, combined with standard care…
PHASE2A Study to Investigate the Efficacy and Safety of SC0032, a Magnesium Salt Oral Spray, in Adults With Refractory or Unexplained Chronic Cough
What is being tested: SC0032, a magnesium salt oral spray formulation, is being evaluated in a randomized placebo-controlled…
Clinical News
Only around half of primary school children got their flu vaccine last year
Flu vaccination uptake in primary school children fell to approximately 50% last year, indicating substantial coverage gaps in…
03 Sep 2026AI sleep data could provide one-week early warning of flu and COVID-19
Sleep-tracking apps analysing cough patterns can detect flu and COVID-19 approximately one week before symptom onset, potentially enabling…
02 Sep 2026Children as young as six going to A&E in mental health crisis
Children as young as six are presenting to A&E with acute mental health crises, including self-harm and eating…
01 Sep 2026‘Baby Tommy’s here, Chelsea’s not’: First-time mum dies in childbirth
Maternal cardiac arrest during labour can occur unexpectedly even in apparently low-risk pregnancies, highlighting the importance of maintaining…
Relevant Mechanisms
Beta-2 Adrenergic and Muscarinic Receptors — COPD/Asthma
Beta-2 Adrenergic and Muscarinic Receptors — COPD/Asthma is a clinically relevant Drug Science explainer. Bronchodilation in obstructive airway disease is…
MechanismCFTR Modulation
CFTR Modulation is a clinically relevant Drug Science explainer. Cystic fibrosis (CF) is caused by mutations in the CFTR gene…
MechanismEGFR Pathway
EGFR Pathway is a clinically relevant Drug Science explainer. The epidermal growth factor receptor (EGFR/ErbB1/HER1) is a transmembrane receptor tyrosine…
MechanismIL-4/IL-13 Axis
IL-4/IL-13 Axis is a clinically relevant Drug Science explainer. Interleukin-4 (IL-4) and interleukin-13 (IL-13) are hallmark type 2 cytokines produced…
MechanismIL-5 Pathway — Severe Eosinophilic Asthma
IL-5 Pathway — Severe Eosinophilic Asthma is a clinically relevant Drug Science explainer. Interleukin-5 (IL-5) is the principal cytokine governing…
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