Prostate cancer screening only for ‘a few thousand’ high risk men

• Genetic risk stratification recommended: UK advisors suggest prostate cancer screening should be restricted to men carrying dangerous genetic variants with a family history of cancer, rather than population-wide screening
• Limited benefit population: This targeted approach would benefit only a few thousand high-risk men, reflecting evidence that universal screening carries more harm than benefit for average-risk populations
• Clinical implication: GPs should prioritise risk assessment and shared decision-making for men with relevant genetic markers and family history, rather than offering routine PSA testing to asymptomatic men

Only men with a dangerous genetic variant and a family history of cancer should be offered screening, say UK advisors.

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