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Fluconazole and clarithromycin are potent CYP450 inhibitors that can cause warfarin INR to double or triple within days; manage this combination with more frequent...
Around 15 percent of emergency hospital admissions in older adults are related to medicines, with risk of harm rising significantly with each additional medicine...
All women planning pregnancy or of childbearing potential should take 400 micrograms of folic acid daily, or 5 milligrams if at higher risk (on...
Lithium levels should be checked every 3–6 months once stable, with annual separate checks of thyroid and renal function because hypothyroidism develops in up...
Hold SADMANS medicines (sulphonylureas, ACE inhibitors, diuretics, metformin, ARBs, NSAIDs, SGLT2 inhibitors) during significant acute illness causing dehydration or vomiting, and restart once the...
GLP-1 receptor agonists mimic gut-derived GLP-1: they increase glucose-dependent insulin release, suppress glucagon and slow gastric emptying. Semaglutide is a once-weekly GLP-1 agonist; tirzepatide...
JAK inhibitors target the JAK-STAT pathway, interrupting intracellular cytokine signalling across several inflammatory diseases. ORAL Surveillance reshaped risk assessment after higher rates of major...
SGLT2 inhibitors block glucose reabsorption in the proximal renal tubule, causing glycosuria with effects that extend beyond HbA1c lowering. DAPA-HF and EMPEROR-Reduced established benefit...
Introduces the ClinicaliQ podcast format for short, practical clinical updates for healthcare professionals. Explains the plan for guideline updates, drug class explainers, crib sheets...
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