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Clinical Trial Active — Not Recruiting Phase III NCT04657991

A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma — Active Not Recruiting • Phase III • Oncology •…

📅 03 Sep 2026 ⏱ 1 min read
Active — Not Recruiting
Check the registry for current status and eligibility criteria.
Status
Active — Not Recruiting
Phase
Phase III
NCT ID
NCT04657991
Start
2021-01-15
Completion
2026-10-30
ClinicaliQ Trial Snapshot
  • A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma — Active Not Recruiting • Phase III • Oncology • NCT04657991.
  • Trial testing combination immunotherapy plus targeted drugs for untreated advanced melanoma with BRAF mutations.

Verify eligibility, endpoints and current status on the original ClinicalTrials.gov registry before acting on this summary.

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What This Trial Is Studying

The purpose of this study is to learn about the effects of three study medicines (encorafenib, binimetinib, and pembrolizumab) given together for the treatment of melanoma that: * is advanced or metastatic (spread to other parts of the body); * has a certain type of abnormal gene called "BRAF"; and * has not received prior treatment. All participants in this study will receive pembrolizumab at the study clinic once every 3 weeks as an intravenous (IV) infusion (given directly into a vein). In addition, half of the participants will take…

Full Trial Details
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Eligibility criteria, protocol, and results when available
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