ClinicaliQ Trial Snapshot
- A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial). — Recruiting • Phase II • Gastroenterology • NCT05895136.
- What is being tested: A combination therapy using human albumin and enoxaparin (low-molecular-weight heparin) in hospitalised patients with decompensated cirrhosis to assess safety and effectiveness during the post-discharge period.
- Patient eligibility overview: The trial targets high-risk patients with decompensated cirrhosis who are being discharged from hospital; specific clinical and biochemical criteria determine inclusion based on poor prognostic indicators.
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What This Trial Is Studying
The goal of this clinical trial is to determine primarily whether a combinatorial therapy based on the administration of human albumin and enoxaparin is safe and effective in patients with decompensated cirrhosis discharged from the hospital. The main questions it aims to answer are: * Is this combinatorial therapy safe and tolerable? * Is this combinatorial therapy effective? * does this combinatorial therapy cost more or less than standard medical therapy? Participants will attend to study visits in which several test will be performed to asses disease evolution while they…
Eligibility Snapshot
- : 1. Age between 18 and 80 years. 2. Patients with decompensated cirrhosis admitted to hospital due to AD according to the EASL-CLIF criteria (rapid onset of ascites, hepatic encephalopathy, portal hypertensive-related gastrointestinal bleeding, bacterial infection, or any combination of these). 3. CLIF-C AD score ≥ 45 at admission or at any time during hospital stay. 4. Recovery from AD and expected to be discharged within the next 72 hours.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.