- A Randomised Feasibility Study of CPAP in Large Airway Collapse — Recruiting • Non-phase study • Respiratory / COPD / Asthma • NCT07504926.
- What is being tested: A feasibility study evaluating the effectiveness and safety of continuous positive airway pressure (CPAP) therapy as a non-invasive treatment for large airway collapse (LAC), including both excessive dynamic airway collapse (EDAC) and tracheomalacia.
- Patient eligibility overview: Adults with confirmed large airway collapse diagnosis (either posterior membrane bowing or weakened tracheal cartilage) experiencing symptomatic airway obstruction, randomised to receive either CPAP intervention or standard care.
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
Large airway collapse (LAC) is an increasingly recognised condition characterised by either bowing of the posterior membrane/trachealis muscle into the trachea or main bronchi (also known as excessive dynamic airway collapse, EDAC) or weakening of the tracheal cartilage (also known as tracheobronchomalacia, TBM).(1-3) LAC often co-exists with other chronic airway conditions, such as asthma or chronic obstructive pulmonary disease (COPD) and is frequently misdiagnosed or overlooked as symptoms, such as shortness of breath, cough and wheeze overlap with other respiratory disease.(1) There is no standardised treatment pathway for patients diagnosed…
- Adult (≥18 years) at visit 1 2. Able to provide informed consent 3. Prior confirmation of LAC (diagnosed either radiographically or with bronchoscopy) 4. Respiratory co-morbidities optimised 5. ≥1 course of antibiotics and/or prednisolone for an exacerbation of chronic airway disease in the preceding 12 months before visit 1.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.