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Clinical Trial Active — Not Recruiting Phase III NCT05726227

A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight

A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight — Active Not Recruiting • Phase III • Diabetes / Metabolic…

📅 09 Sep 2026 ⏱ 1 min read
Active — Not Recruiting
Check the registry for current status and eligibility criteria.
Status
Active — Not Recruiting
Phase
Phase III
NCT ID
NCT05726227
Start
2023-07-07
Completion
2025-10-15
ClinicaliQ Trial Snapshot
  • A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight — Active Not Recruiting • Phase III • Diabetes / Metabolic • NCT05726227.
  • Semaglutide weekly injections help children and teenagers lose weight better than placebo, alongside lifestyle support.

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What This Trial Is Studying

This study will look at how well semaglutide helps children and teenagers losing weight. This will be tested by comparing the effect on body weight in children and teenagers taking semaglutide in comparison to placebo, a "dummy" medicine. In addition to taking the medicine, the child's parent and the child will have talks with study staff about healthy food choices, how to be more physically active and what your child can do to try to lose weight. The child will either get semaglutide or a "dummy" medicine. Which treatment the…

Full Trial Details
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Eligibility criteria, protocol, and results when available
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Related Clinical Intelligence

Guidelines, Drug Science, safety briefs and education connected to this trial area.

Guideline
Semaglutide for Managing Overweight and Obesity (NICE TA875)
Diabetes / Metabolic · 27 Mar 2026
Initiate semaglutide only in specialist obesity services or via shared care with clear primary-secondary care protocols for adults with BMI ≥30 kg/m²…
View guideline →
Clinical Brief
Why weight-loss jabs work better for some people than others
Diabetes / Metabolic · BBC Health · 10 Apr 2026
Genetic variations in appetite and digestion genes predict differential weight-loss responses to GLP-1 receptor agonists (Wegovy, Mounjaro), suggesting personalised medicine approaches may…
View brief →
Podcast
GLP-1 Agonists: Semaglutide, Tirzepatide and the Cardiovascular Revolution
Diabetes / Metabolic · 00:15:32 · 03 Apr 2026
GLP-1 receptor agonists mimic gut-derived GLP-1: they increase glucose-dependent insulin release, suppress glucagon and slow gastric emptying. Semaglutide is a once-weekly GLP-1…
Listen →
Guideline
Tirzepatide for Managing Overweight and Obesity (NICE TA1026)
Diabetes / Metabolic · 27 Mar 2026
Prescribe tirzepatide to adults with BMI ≥35 kg/m² or BMI 30–34.9 kg/m² with weight-related comorbidities, initiating treatment in specialist weight management services…
View guideline →
Clinical Brief
Daily pill to help keep weight off after stopping obesity jabs
Diabetes / Metabolic · BBC Health · 12 May 2026
Orforglipron is a daily oral tablet offering an alternative to GLP-1 receptor agonist injections for weight maintenance after obesity treatment cessation The…
View brief →
Guideline
Obesity: Identification, Assessment and Management (NICE CG189)
Diabetes / Metabolic · 27 Mar 2026
Use BMI thresholds to identify obesity (≥30 kg/m² in adults; ≥27.5 kg/m² in Asian populations) and offer structured first-line weight loss interventions…
View guideline →