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Clinical Trial Active — Not Recruiting Phase III NCT03811561

A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes — Active Not Recruiting • Phase III…

📅 04 Aug 2026 ⏱ 1 min read
Active — Not Recruiting
Check the registry for current status and eligibility criteria.
Status
Active — Not Recruiting
Phase
Phase III
NCT ID
NCT03811561
Start
2019-05-08
Completion
2027-11-07
ClinicaliQ Trial Snapshot
  • A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes — Active Not Recruiting • Phase III • Diabetes / Metabolic • NCT03811561.
  • Semaglutide injection tested against placebo over five years to see if it slows diabetic eye disease in type 2 diabetes.

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What This Trial Is Studying

This study will look at the long-term effects of semaglutide (active medicine) on diabetic eye disease when compared to placebo (dummy medicine). The study will be performed in people with type 2 diabetes. Participants will either get semaglutide or placebo in addition to their diabetes medicines - which treatment the participant gets is decided by chance. Participants will inject the study medicine using a pen-injector. The medicine must be injected in a skin fold in the stomach, thigh or upper arm once a week. The study will last for 5…

Full Trial Details
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Eligibility criteria, protocol, and results when available
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Guideline
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Clinical Brief
Weekly type 2 diabetes jab could replace daily injections
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Guideline
Semaglutide for Managing Overweight and Obesity (NICE TA875)
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Initiate semaglutide only in specialist obesity services or via shared care with clear primary-secondary care protocols for adults with BMI ≥30 kg/m²…
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Guideline
Type 1 Diabetes in Adults: Diagnosis and Management (NICE NG17)
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Podcast
GLP-1 Agonists: Semaglutide, Tirzepatide and the Cardiovascular Revolution
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GLP-1 receptor agonists mimic gut-derived GLP-1: they increase glucose-dependent insulin release, suppress glucagon and slow gastric emptying. Semaglutide is a once-weekly GLP-1…
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