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Clinical Trial Active — Not Recruiting Phase III NCT05455320

A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment

A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma…

📅 25 Sep 2026 ⏱ 1 min read
Active — Not Recruiting
Check the registry for current status and eligibility criteria.
Status
Active — Not Recruiting
Phase
Phase III
NCT ID
NCT05455320
Start
2022-10-13
Completion
2027-07-30
ClinicaliQ Trial Snapshot
  • A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment — Active Not Recruiting •….
  • New drug talquetamab combined with daratumumab tested against standard treatment in relapsed/resistant myeloma patients.

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What This Trial Is Studying

The purpose of the study is to compare the efficacy of talquetamab subcutaneous(ly) (SC) in combination with daratumumab SC and pomalidomide (Tal-DP) and talquetamab SC in combination with daratumumab SC (Tal-D), respectively, with daratumumab SC in combination with pomalidomide and dexamethasone (DPd). Conditions: Multiple Myeloma Interventions: Talquetamab, Daratumumab, Pomalidomide, Dexamethasone Lead Sponsor: Janssen Research & Development, LLC Planned Enrollment: 864 participants

Full Trial Details
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Eligibility criteria, protocol, and results when available
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