Oncology Cardiology / Cardiovascular Respiratory / COPD / Asthma Infectious Disease Gastroenterology Diabetes / Metabolic Neurology Rheumatology Women's Health Mental Health / Psychiatry Dermatology Rare Diseases Men's Health
Clinical Trial Active — Not Recruiting Phase II NCT06395948

A Study Evaluating APG777 in Atopic Dermatitis

A Study Evaluating APG777 in Atopic Dermatitis — Active Not Recruiting • Phase II • Dermatology • NCT06395948.

📅 22 Jul 2026 ⏱ 1 min read
Active — Not Recruiting
Check the registry for current status and eligibility criteria.
Status
Active — Not Recruiting
Phase
Phase II
NCT ID
NCT06395948
Start
2024-04-29
Completion
2026-11
ClinicaliQ Trial Snapshot
  • A Study Evaluating APG777 in Atopic Dermatitis — Active Not Recruiting • Phase II • Dermatology • NCT06395948.
  • Trial testing a new drug (APG777) to treat moderate-to-severe eczema, comparing different doses against placebo over 106 weeks.

Verify eligibility, endpoints and current status on the original ClinicalTrials.gov registry before acting on this summary.

Use This Page For
  • Quick orientation before opening the registry record.
  • Checking recruitment status, phase and sponsor at a glance.
  • Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying

This is a two-part study that will evaluate the safety and efficacy of APG777 in participants with moderate-to-severe Atopic Dermatitis (AD). Part A (Proof-of-concept) and Part B (Dose-regimen Finding) will evaluate the safety and efficacy of various induction and maintenance dose regimens of APG777 compared to placebo. The study duration for any individual participant will be up to 106 weeks which includes: screening, induction, maintenance, and post-treatment follow-up periods. Participants randomized in Part A are not permitted to participate in Part B. Conditions: Atopic Dermatitis Interventions: APG777, Placebo Lead Sponsor:…

Full Trial Details
View this trial on the source registry
Eligibility criteria, protocol, and results when available
View Trial ↗
Share: Twitter/X LinkedIn
Related

Related Clinical Intelligence

Guidelines, Drug Science, safety briefs and education connected to this trial area.

Guideline
Atopic Eczema in Under 12s: Diagnosis and Management (NICE NG190)
Dermatology · 27 Mar 2026
Diagnose atopic eczema clinically based on itching, typical morphology and distribution, onset before age 2 years, and history of dry skin or…
View guideline →
Clinical Brief
Topical steroids: introduction of new labelling and a reminder of the possibility of severe side effects, including Topical Steroid Withdrawal Reactions
Dermatology · MHRA · 29 May 2024
Topical steroid products are safe and highly effective treatments for the management of a wide range of inflammatory skin diseases but have…
View brief →
Clinical Brief
Hundreds contact BBC about mystery skin condition ‘hell’ – but doctors can’t agree it exists
Dermatology · BBC Health · 10 Apr 2026
Doctors remain divided on whether a severe skin condition reported by hundreds of patients represents extreme eczema or a distinct entity called…
View brief →
Guideline
Subcutaneous spesolimab 1-ml formulation for preventing generalised pustular psoriasis flares in people 12 years and over (terminated appraisal)
Dermatology · 08 Apr 2026
This NICE publication is marked as a terminated appraisal, so it functions as a status notice rather than an active treatment recommendation…
View guideline →
Drug Science
BRAF/MEK Pathway — Melanoma
Dermatology · 04 Apr 2026
BRAF/MEK Pathway — Melanoma is a clinically relevant Drug Science explainer. The MAPK signalling cascade (RAS-RAF-MEK-ERK) transmits extracellular growth signals from receptor…
Explore mechanism →
Clinical Brief
Tens of thousands with vitiligo to be offered “life-changing” new cream on NHS to restore skin colour
Dermatology · NHS England · 24 Feb 2026
Tens of thousands of people living with vitiligo affecting their face are to be offered the first approved medicine on the NHS…
View brief →