- A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006) — Active Not Recruiting • Phase III • NCT06079879.
- New drug bomedemstat compared to standard treatment for essential thrombocythemia patients who don't respond to or tolerate hydroxyurea.
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This is a study evaluating the safety and efficacy of bomedemstat (MK-3543) compared with the best available therapy (BAT) in participants with essential thrombocythemia (ET) who have an inadequate response to or are intolerant of hydroxyurea. The primary study hypothesis is that bomedemstat is superior to the best available therapy with respect to durable clinicohematologic response (DCHR). Conditions: Essential Thrombocythemia Interventions: Bomedemstat, Anagrelide, Busulfan, Interferon alfa/pegylated interferon alfa 2a/pegylated interferon alfa 2b, Ruxolitinib Lead Sponsor: Merck Sharp & Dohme LLC Planned Enrollment: 340 participants