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Clinical Trial Active — Not Recruiting Phase II NCT05242484

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis — Active Not Recruiting • Phase II • Gastroenterology •…

📅 28 Aug 2026 ⏱ 1 min read
Active — Not Recruiting
Check the registry for current status and eligibility criteria.
Status
Active — Not Recruiting
Phase
Phase II
NCT ID
NCT05242484
Start
2022-09-19
Completion
2025-05-15
ClinicaliQ Trial Snapshot
  • A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis — Active Not Recruiting • Phase II • Gastroenterology • NCT05242484.
  • Combining two biologic drugs (guselkumab and golimumab) tested for treating ulcerative colitis in patients who haven't responded to other treatments.

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What This Trial Is Studying

The purpose of this study is to evaluate the efficacy and safety of JNJ-78934804 as compared to guselkumab and golimumab in participants with moderately to severely active ulcerative colitis who have had an inadequate initial response, loss of response, or intolerance to one or more approved advanced therapy. Conditions: Colitis, Ulcerative Interventions: Guselkumab, Golimumab, JNJ-78934804, Placebo Lead Sponsor: Janssen Research & Development, LLC Planned Enrollment: 577 participants

Full Trial Details
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Eligibility criteria, protocol, and results when available
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