ClinicaliQ Trial Snapshot
- A Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of LRK-4189 Alone and in Combination in Patients With Solid Tumors — Recruiting • Phase I • Oncology • NCT07498725.
- What is being tested: LRK-4189, an investigational agent, is being evaluated as a monotherapy and in combination regimens for treating solid tumors, with particular focus on colorectal cancer efficacy and safety profile.
- Patient eligibility overview: Adults with solid tumors are eligible, with emphasis on those with colorectal cancer; standard trial inclusion/exclusion criteria apply regarding performance status and organ function.
Use This Page For
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying
The goal of this clinical trial is to learn if investigational agent LRK-4189 works to treat solid tumors in adults, with a focus on colorectal cancer. It will also learn about the safety of drug LRK-4189. The main questions it aims to answer are: Is LRK-4189, administered alone or in combination with standard chemotherapy regimens, safe and tolerable in patients with solid tumors? Participants will: * Take investigational agent LRK-4189 alone or in combination with standard chemotherapy regimens every day for up to 3 years. * Visit the clinic once…
Eligibility Snapshot
- : * Willing and able to sign the study consent form and take part in all required study visits, tests, and procedures. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1. * Have a locally advanced or metastatic cancer that cannot be removed with surgery and has gotten worse despite treatment. * Cancer can be measured on scans, such as CT or MRI. * Willing to have tumor biopsies, meaning small samples of your tumor will be collected during the study. * Heart rhythm test (ECG) shows a normal result within safe limits. * Blood test results at screening are within an acceptable and stable range. * If you are a woman, you are not able to become pregnant, or you agree not to become pregnant during the study and to use approved birth control methods. * If you are a man, you agree not to donate sperm during the study. If you have sex with a partner who could become pregnant, you agree to use approved birth control methods during the study.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.